Hydrochlorothiazide and spironolactone

Generic name: Hydrochlorothiazide And Spironolactone
Brand names: Aldactazide
Dosage form: oral tablet (25 mg-25 mg; 50 mg-50 mg)
Drug class: Potassium sparing diuretics with thiazides

Usage of Hydrochlorothiazide and spironolactone

Hydrochlorothiazide is a thiazide diuretic (water pill). Spironolactone is a potassium-sparing diuretic.

Hydrochlorothiazide and spironolactone is a combination medicine used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome. hydrochlorothiazide and spironolactone also treats high blood pressure (hypertension), or low potassium levels (hypokalemia) caused by using a diuretic.

Do not use this medicine for any condition that has not been checked by your doctor.

Hydrochlorothiazide and spironolactone may also be used for purposes not listed in this medication guide.

Hydrochlorothiazide and spironolactone side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Hydrochlorothiazide and spironolactone may cause serious side effects. Call your doctor at once if you have:

a light-headed feeling, like you might pass out;

blurred vision, tunnel vision, eye pain, or seeing halos around lights;

breast swelling and tenderness;

low blood cell counts--easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath;

high potassium level--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement;

low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or

low sodium level --headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.

Common side effects of hydrochlorothiazide and spironolactone may include:

drowsiness, dizziness, lack of energy;

leg cramps;

weakness;

feeling like you might pass out;

severe pain in your upper stomach spreading to your back, nausea and vomiting; or

electrolyte imbalance.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Hydrochlorothiazide and spironolactone

You should not use this medicine if you are allergic to hydrochlorothiazide or spironolactone, or if you have:

kidney disease or urination problems;

liver disease;

high levels of calcium or potassium in your blood;

an allergy to sulfa drugs; or

Addison's disease (an adrenal gland disorder).

Tell your doctor if you have ever had:

cirrhosis or other liver disease;

severe kidney disease;

asthma or allergies;

glaucoma;

gout;

diabetes; or

lupus.

In animal studies, spironolactone caused certain types of tumors. It is not known whether tumors could occur in people using this medicine. Ask your doctor about your risk.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breastfeed while using this medicine.

This medicine is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Hydrochlorothiazide and spironolactone

Usual Adult Dose for Hypertension:

Hydrochlorothiazide 50 to 100 mg-Spironolactone 50 to 100 mg orally daily in 1 to 2 divided dosesUses:-Treatment of essential hypertension when other measures are considered inadequate or inappropriate.-Treatment of diuretic-induced hypokalemia in hypertensive patients when other measures are considered inappropriate.-Treatment of hypertension.

Usual Adult Dose for Edema:

Hydrochlorothiazide 25 to 200 mg-Spironolactone 25 to 200 mg orally daily in 1 to 2 divided doses

Usual Adult Dose for Congestive Heart Failure:

Hydrochlorothiazide 25 to 200 mg-Spironolactone 25 to 200 mg orally daily in 1 to 2 divided dosesUses:-Management of edema and sodium retention when the patient is only partially responsive to, or is intolerant of, other therapeutic measures.-Treatment of diuretic-induced hypokalemia in patients with congestive heart failure (CHF) when other measures are considered inappropriate.-Treatment of patients with CHF taking digitalis when other therapies are considered inadequate or inappropriate.

Usual Adult Dose for Ascites:

Hydrochlorothiazide 25 to 200 mg-Spironolactone 25 to 200 mg orally daily in 1 to 2 divided dosesUse: Maintenance therapy together with bed rest and fluid and sodium restriction for cirrhosis of the liver accompanied by edema and/or ascites.

Usual Adult Dose for Nephrotic Syndrome:

Hydrochlorothiazide 25 to 200 mg-Spironolactone 25 to 200 mg orally daily in 1 to 2 divided dosesUse: For nephrotic patients when treatment of the underlying disease, restriction of fluid and sodium intake, and the use of other diuretics do not provide an adequate response.

Warnings

You should not use hydrochlorothiazide and spironolactone if you have kidney problems, Addison's disease, high blood levels of calcium or potassium, an allergy to sulfa drugs, or if you are unable to urinate.

What other drugs will affect Hydrochlorothiazide and spironolactone

Using this medicine with other drugs that make you drowsy or lower your blood pressure can worsen these effects. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your other medicines, especially:

cholestyramine;

digoxin;

lithium;

heart or blood pressure medicine, especially another diuretic;

insulin or oral diabetes medicine;

medicine to prevent a blood clot;

NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), Celecoxib, diclofenac, indomethacin, meloxicam, and others; or

steroid medicine--Dexamethasone, prednisone, or others.

This list is not complete. Other drugs may affect hydrochlorothiazide and spironolactone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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