Hydrochlorothiazide and valsartan

Generic name: Hydrochlorothiazide And Valsartan
Brand names: Diovan HCT
Dosage form: oral tablet (12.5 mg-160 mg; 12.5 mg-320 mg; 12.5 mg-80 mg; 25 mg-160 mg; 25 mg-320 mg)
Drug class: Angiotensin II inhibitors with thiazides

Usage of Hydrochlorothiazide and valsartan

Hydrochlorothiazide is a diuretic (water pill). Valsartan is an angiotensin II receptor blocker (sometimes called an ARB blocker).

Hydrochlorothiazide and valsartan is a combination medicine used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack.

Hydrochlorothiazide and valsartan is given after other blood pressure medicines did not work or have stopped working.

Hydrochlorothiazide and valsartan may also be used for purposes not listed in this medication guide.

Hydrochlorothiazide and valsartan side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, hydrochlorothiazide and valsartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark colored urine.

Hydrochlorothiazide and valsartan may cause serious side effects. Call your doctor at once if you have:

a light-headed feeling, like you might pass out;

eye pain, vision problems;

an unusual skin rash;

little or no urinating;

jaundice (yellowing of the skin or eyes);

easy bruising, unusual bleeding;

a seizure;

kidney problems--little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath; or

signs of an electrolyte imbalance--dry mouth, increased thirst, confusion, feeling restless, vomiting, muscle pain or weakness, drowsiness, lack of energy, fast heartbeats, decreased urination.

Common side effects include:

cold symptoms such as stuffy nose, sneezing, sore throat;

dizziness; or

headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Hydrochlorothiazide and valsartan

You should not use this medicine if you are allergic to valsartan or hydrochlorothiazide, or if you have:

decreased urination or are unable to urinate; or

an allergy to sulfa drugs.

If you have diabetes, do not use hydrochlorothiazide and valsartan together with any medication that contains aliskiren (a blood pressure medicine).

You may also need to avoid taking hydrochlorothiazide and valsartan with aliskiren if you have kidney disease.

Tell your doctor if you have ever had:

an electrolyte imbalance (such as low levels of potassium or magnesium, or high levels of calcium in your blood);

liver disease;

kidney disease;

gallstones;

lupus;

congestive heart failure;

gout, or high levels of uric acid in your blood;

asthma or allergies;

high cholesterol or triglyceride levels;

an allergy to penicillin;

glaucoma; or

if you are on a low-salt diet.

Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Valsartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

You should not breastfeed while using this medicine.

Hydrochlorothiazide and valsartan is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Hydrochlorothiazide and valsartan

Usual Adult Dose for Hypertension:

Initial dose: 1 tablet (12.5 mg-160 mg) orally once a day Maintenance dose: Titrate as necessary (every 1 to 2 weeks) up to a maximum of 25 mg-320 mg orally once a dayComment:-Hydrochlorothiazide-valsartan may be substituted for the titrated components.

Warnings

You should not use hydrochlorothiazide and valsartan if you are unable to urinate, or if you are allergic to sulfa drugs.

Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant.

If you have diabetes, do not use hydrochlorothiazide and valsartan together with any medication that contains aliskiren (a blood pressure medicine).

What other drugs will affect Hydrochlorothiazide and valsartan

If you also take cholestyramine or colestipol, take your hydrochlorothiazide and valsartan dose 4 hours before or 4 hours after you take the other medicine.

Tell your doctor about all your current medicines. Many drugs can affect hydrochlorothiazide and valsartan, especially:

cyclosporine, digoxin, digitalis, lithium, or ritonavir;

all your heart or blood pressure medicines;

insulin or oral diabetes medicine;

a diuretic or "water pill";

opioid pain medicine;

a sleeping pill;

a muscle relaxer;

an antibiotic--rifabutin, rifampin, rifamycin, rifapentine;

cancer medicine--cyclophosphamide, methotrexate; or

NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), Celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete and many other drugs may affect hydrochlorothiazide and valsartan. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

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