Hyftor

Generic name: Sirolimus
Dosage form: topical gel

Usage of Hyftor

Hyftor is a prescription medicine that is used on the skin (topical) to treat adults and children 6 years of age and older with a type of noncancerous tumor called angiofibroma on your face caused by the genetic condition tuberous sclerosis.

It is not known if this medicine is safe and effective in children under 6 years of age.

Do not use Hyftor if you are allergic to sirolimus or any of the other ingredients. See the end of this page for a complete list of ingredients.

Important: Hyftor is for use on the skin only (topical use). Do not use the gel in your mouth, eyes, or vagina.

Hyftor side effects

Hyftor may cause serious side effects, including:

Allergic reactions. Serious allergic reactions have happened in people who have taken sirolimus by mouth. Stop using Hyftor and get medical help right away if you get any of these symptoms of a serious allergic reaction:

swelling of your face, eyes, or mouth

chest pain or tightness

trouble breathing or wheezing

feeling dizzy or faint

throat tightness

rash or peeling of your skin

Infections. Serious infections, including infections that can happen when your immune system is weak, have happened in people who have taken sirolimus by mouth. Some people have developed a rare, serious brain infection called progressive multifocal leukoencephalopathy (PML) which can sometimes cause death. Stop treatment and call your healthcare provider right away if you get symptoms of an infection including fever or chills.

Risk of cancer. Lymphoma and other cancers, especially skin cancer, have happened in people who have taken sirolimus by mouth. Talk with your healthcare provider about your risk for cancer if you use Hyftor.

Increased levels of cholesterol and triglycerides (fat or lipids) in the blood have happened in people who have taken sirolimus by mouth. Your healthcare provider may do blood tests to check you for high lipid levels during treatment with Hyftor and treat you, if needed.

Lung or breathing problems. Lung or breathing problems, including problems that have sometimes caused death, have happened in people who have taken sirolimus by mouth. Stop treatment and get medical help right away if you get symptoms such as shortness of breath, new or worsening cough, or chest pain.

The most common side effects include dry skin, application site irritation, itching, acne, acne-like rash, eye redness, skin bleeding, and skin irritation. Hyftor may cause fertility problems in males and females, which may affect your ability to have children. Talk to your healthcare provider if this is a concern for you.

These are not all the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Hyftor

Before you start treatment, tell your healthcare provider about all of your medical conditions, including if you:

have a skin infection at the treatment site

have high cholesterol or high triglycerides (fat or lipids) in your blood

are scheduled to receive an immunization (vaccine). You should avoid receiving live vaccines during treatment with Hyftor. Vaccines may be less effective.

are pregnant or plan to become pregnant. Hyftor may harm your unborn baby. You should not become pregnant during treatment.

Females who are able to become pregnant should use effective birth control (contraception) before starting, during treatment, and for 12 weeks after your final dose. Talk to your healthcare provider about types of birth control that you can use during this time.

are breastfeeding or plan to breastfeed. It is not known if Hyftor passes into your breast milk. You should not breastfeed during treatment.

How to use Hyftor

Usual Adult Dose for Facial Angiofibroma Associated with Tuberous Sclerosis

- Apply to the skin of the face affected with angiofibroma twice daily. The maximum daily dosage is 800 mg (2.5 cm) for patients 12 years of age and older.

Usual Pediatric Dose for Facial Angiofibroma Associated with Tuberous Sclerosis

-Apply to the skin of the face affected with angiofibroma twice daily. The maximum daily dosage is 600 mg (2 cm) for patients 6 to 11 years of age.

What other drugs will affect Hyftor

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using Hyftor with certain medicines may affect each other causing side effects.

Disclaimer

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