Ibuprofen and famotidine

Generic name: Ibuprofen And Famotidine
Drug class: Nonsteroidal anti-inflammatory drugs

Usage of Ibuprofen and famotidine

ibuprofen and Famotidine combination is used to relieve the symptoms of rheumatoid arthritis and osteoarthritis. It is used for patients who have an increased risk for stomach ulcers and who need to take a nonsteroidal anti-inflammatory drug (NSAID) for arthritis.

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat pain, inflammation, swelling, stiffness, and joint pain. Famotidine is a histamine H2-receptor antagonist or H2-blocker. It works by decreasing the amount of acid produced by the stomach.

This medicine is available only with your doctor's prescription.

Ibuprofen and famotidine side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Bladder pain

bloating or swelling of the face, arms, hands, lower legs, or feet

bloody or black, tarry stools

blurred vision

chills

clay-colored stools

cloudy urine

constipation

cough

dark-colored urine

diarrhea

difficult, burning, or painful urination

dizziness

fever

frequent urge to urinate

general feeling of discomfort or illness

headache

heartburn

indigestion

itching or rash

joint pain

light-colored stools

loss of appetite

lower back or side pain

muscle aches and pains

nausea

nervousness

pale skin

pounding in the ears

rapid weight gain

runny nose

severe stomach pain

shivering

slow or fast heartbeat

sore throat

stomach pain, cramping, or burning

sweating

tingling of the hands or feet

trouble sleeping

trouble breathing

unpleasant breath odor

unusual bleeding or bruising

unusual tiredness or weakness

unusual weight gain or loss

vomiting

vomiting of blood or material that looks like coffee grounds

yellow eyes or skin

Incidence not known

Blistering, peeling, or loosening of the skin

change in consciousness

confusion as to time, place, or person

cracks in the skin

darkening of the skin

depression

dry mouth

fainting

hallucinations

holding false beliefs that cannot be changed by fact

loss of consciousness

loss of heat from the body

pain in the lower back or side

pain in the chest, groin, or legs, especially calves of the legs

red skin lesions, often with a purple center

red, irritated eyes

red, swollen skin

scaly skin

seizures

severe headaches of sudden onset

sores, ulcers, or white spots in the mouth or on the lips

stiff neck or back

sudden loss of coordination

sudden onset of slurred speech

sudden vision changes

swollen glands

thirst

unusual excitement, nervousness, or restlessness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Back pain

belching

body aches or pain

cough producing mucus

difficulty having a bowel movement

difficulty with moving

ear congestion

loss of voice

muscle stiffness

pain or tenderness around the eyes and cheekbones

sneezing

stuffy nose

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Ibuprofen and famotidine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever HAD any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of ibuprofen and famotidine combination in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ibuprofen and famotidine combination in the elderly. However, elderly patients are more likely to have age-related heart, stomach, or kidney problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Bepridil

Cisapride

Dronedarone

Ketorolac

Levoketoconazole

Mesoridazine

Pimozide

Piperaquine

Saquinavir

Sparfloxacin

Terfenadine

Thioridazine

Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abciximab

Acalabrutinib

AceclofeNAC

Acemetacin

Acenocoumarol

Adagrasib

Amiloride

Amineptine

Amiodarone

Amisulpride

Amitriptyline

Amitriptylinoxide

Amoxapine

Amprenavir

Amtolmetin Guacil

Anagrelide

Apixaban

Apomorphine

Ardeparin

Argatroban

Aripiprazole

Aripiprazole Lauroxil

Arsenic Trioxide

Aspirin

Atazanavir

Balsalazide

Bemetizide

Bemiparin

Bendroflumethiazide

Benzthiazide

Betamethasone

Betrixaban

Bismuth Subsalicylate

Bivalirudin

Bromfenac

Budesonide

Bufexamac

Bumetanide

Buprenorphine

Bupropion

Buserelin

Cangrelor

Cefuroxime Axetil

Celecoxib

Ceritinib

Certoparin

Chloroquine

Chlorothiazide

Chlorthalidone

Choline Magnesium Trisalicylate

Choline Salicylate

Cilostazol

Citalopram

Clarithromycin

Clofazimine

Clomipramine

Clonixin

Clopamide

Clopidogrel

Clothiapine

Clozapine

Cortisone

Crizotinib

Cyclopenthiazide

Cyclosporine

Cyclothiazide

Dabigatran Etexilate

Dabrafenib

Dalteparin

Danaparoid

Dasatinib

Deflazacort

Degarelix

Delamanid

Delavirdine

Desipramine

Desirudin

Deslorelin

Desmopressin

Desvenlafaxine

Deutetrabenazine

Dexamethasone

Dexibuprofen

Dexketoprofen

Dexmedetomidine

Diazoxide

Dibenzepin

Diclofenac

Diflunisal

Digoxin

Dipyridamole

Dipyrone

Domperidone

Donepezil

Dothiepin

Doxepin

Droxicam

Duloxetine

Edoxaban

Efavirenz

Emtricitabine

Encorafenib

Enoxaparin

Entrectinib

Eplerenone

Epoprostenol

Eptifibatide

Erlotinib

Escitalopram

Ethacrynic Acid

Etodolac

Etofenamate

Etoricoxib

Etozolin

Etrasimod

Felbinac

Fenoprofen

Fepradinol

Feprazone

Feverfew

Fexinidazole

Fingolimod

Floctafenine

Fluconazole

Flufenamic Acid

Fluocortolone

Fluoxetine

Flurbiprofen

Fluvoxamine

Fondaparinux

Formoterol

Fosamprenavir

Foscarnet

Fostemsavir

Furosemide

Gefitinib

Gepirone

Ginkgo

Glasdegib

Gonadorelin

Goserelin

Gossypol

Heparin

Histrelin

Hydrochlorothiazide

Hydrocortisone

Hydroflumethiazide

Hydroxychloroquine

Hydroxyzine

Iloprost

Imipramine

Indapamide

Indomethacin

Infigratinib

Inotersen

Inotuzumab Ozogamicin

Ivabradine

Ivosidenib

Ketoconazole

Ketoprofen

Ledipasvir

Lefamulin

Lenvatinib

Lepirudin

Leuprolide

Levofloxacin

Levomilnacipran

Lithium

Lofepramine

Lofexidine

Lornoxicam

Loxoprofen

LuMacaftor

Lumiracoxib

Macimorelin

Mavacamten

Meadowsweet

Meclofenamate

Mefenamic Acid

Melitracen

Meloxicam

Melphalan

Mesalamine

Methadone

Methotrexate

Methyclothiazide

Methylphenidate

Methylprednisolone

Metolazone

Metronidazole

Milnacipran

Mirtazapine

Mobocertinib

Morniflumate

Moxifloxacin

Nabumetone

Nadroparin

Nafarelin

Naproxen

Nefazodone

Nepafenac

Neratinib

Niflumic Acid

Nimesulide

Nimesulide Beta Cyclodextrin

Nortriptyline

Octreotide

Olanzapine

Olsalazine Sodium

Ondansetron

Opipramol

Osilodrostat

Osimertinib

Oxaliplatin

Oxaprozin

Oxyphenbutazone

Ozanimod

Pacritinib

Panobinostat

Paramethasone

Parecoxib

Parnaparin

Paroxetine

Pasireotide

Pazopanib

Pemetrexed

Pentosan Polysulfate Sodium

Pentoxifylline

Phenindione

Phenobarbital

Phenprocoumon

Phenylbutazone

Piketoprofen

Pimavanserin

Piretanide

Piroxicam

Pitolisant

Polythiazide

Ponesimod

Posaconazole

Potassium Citrate

Pranoprofen

Prasugrel

Prednisolone

Prednisone

Primidone

Proglumetacin

Propyphenazone

Proquazone

Protein C

Protriptyline

Quetiapine

Quinethazone

Quizartinib

Relugolix

Reviparin

Ribociclib

Rilpivirine

Rivaroxaban

Rofecoxib

Salicylic Acid

Salsalate

Secretin Human

Selexipag

Selpercatinib

Sertraline

Sevoflurane

Sibutramine

Siponimod

Sodium Salicylate

Solifenacin

Sotalol

Sotorasib

Sparsentan

Spironolactone

Sulfasalazine

Sulfinpyrazone

Sulindac

Sulodexide

Sulpiride

Sunitinib

Tacrolimus

Tenofovir Alafenamide

Tenofovir Disoproxil Fumarate

Tenoxicam

Tianeptine

Tiaprofenic Acid

Ticagrelor

Ticlopidine

Tinzaparin

Tirofiban

Tizanidine

Tocilizumab

Tolazoline

Tolfenamic Acid

Tolmetin

Torsemide

Trazodone

Treprostinil

Triamterene

Trichlormethiazide

Triclabendazole

Trimipramine

Triptorelin

Valdecoxib

Vandetanib

Vardenafil

Vemurafenib

Venlafaxine

Vilanterol

Vilazodone

Vinflunine

Vismodegib

Voclosporin

Vorapaxar

Vortioxetine

Warfarin

Xipamide

Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acebutolol

Amikacin

Atenolol

Azilsartan

Azilsartan Medoxomil

Benazepril

Betaxolol

Bisoprolol

Candesartan

Captopril

Carteolol

Carvedilol

Cefditoren Pivoxil

Cefpodoxime Proxetil

Celiprolol

Cyclosporine

Enalapril

Enalaprilat

Eprosartan

Esmolol

Fosinopril

Irbesartan

Labetalol

Levobunolol

Lisinopril

Losartan

Metipranolol

Metoprolol

Moexipril

Nadolol

Nebivolol

Olmesartan

Oxprenolol

Penbutolol

Perindopril

Pindolol

Propranolol

Quinapril

Ramipril

Sotalol

Spirapril

Telmisartan

Timolol

Trandolapril

Valsartan

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Ethanol

Tobacco

Relate drugs

How to use Ibuprofen and famotidine

Use this medicine exactly as ordered by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than ordered by your doctor. To do so may increase the chance of unwanted effects, especially in elderly patients.

This medicine comes with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

Swallow the tablet whole. Do not break, crush, divide, or chew it.

This medicine contains ibuprofen. Do not take this medicine with other products containing ibuprofen.

Do not substitute this medicine with single-ingredient products of ibuprofen and famotidine. Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets):

For rheumatoid arthritis and osteoarthritis:

Adults—1 tablet (800 milligrams (mg) ibuprofen and 26.6 mg famotidine) 3 times a day.

Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Warnings

It is very important that your doctor check your progress at regular visits while you are using this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to use it. Blood and urine tests may be needed to check for unwanted effects.

Ibuprofen may increase your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use this medicine for a long time might also have a higher risk. Check with your doctor right away if you are having chest pain or discomfort, nausea or vomiting, pain or discomfort in the arms, jaw, back, or neck, trouble breathing, slurred speech, or weakness.

Ibuprofen may cause bleeding in your stomach or intestines. This problem can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years of age, are in poor health, or are using certain other medicines (eg, steroids or a blood thinner).

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Your blood pressure might get too high while you are using this medicine. This may cause headaches, dizziness, or blurred vision. You might need to measure your blood pressure at home. If you think your blood pressure is too high, call your doctor right away.

If you are rapidly gaining weight, trouble breathing, chest pain or discomfort, extreme tiredness or weakness, irregular breathing, irregular heartbeat, or excessive swelling of the hands, wrist, ankles, or feet, check with your doctor immediately. These may be symptoms of heart problems or your body keeping too much water.

Check with your doctor right away if you have blood in the urine, decrease in the frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, trouble breathing, unusual tiredness or weakness, vomiting, or weight gain. These may be symptoms of a serious kidney problem.

Hyperkalemia (high potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you have stomach pain, confusion, difficulty with breathing, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in the hands, feet, or lips, or weakness or heaviness of the legs.

This medicine may cause a serious allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Serious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS) can occur with this medicine. Check with your doctor right away if you have black, tarry stools, blistering, peeling, or loosening of the skin, chest pain, chills, cough, fever, painful or difficult urination, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots on the lips or in the mouth, swollen glands, unusual bleeding or bruising, or unusual tiredness and weakness.

Using this medicine during the later part of pregnancy can harm your unborn baby. If you think you have become pregnant while using this medicine, tell your doctor right away.

This medicine may cause a delay in ovulation for women and may affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.

Some people who have used this medicine had symptoms of meningitis. If you have fever, headache, nausea, vomiting, and stiff neck or back while using this medicine, check with your doctor right away.

Check with your doctor right away if blurred vision, difficulty with reading, or any other change in vision occurs during or after your treatment. Your doctor may want your eyes be checked by an ophthalmologist (eye doctor).

Before having any kind of surgery or medical tests, tell your doctor that you are using this medicine. It may be necessary for you to stop the medicine for a while, or to change to a different medicine before your procedure.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

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