Ilaris
Generic name: Canakinumab
Dosage form: subcutaneous injection
Drug class:
Interleukin inhibitors
Usage of Ilaris
Ilaris is used to treat certain types of periodic fever syndromes, Still’s Disease and gout flares. Ilaris works by blocking proteins in the body that can affect inflammation and other immune responses. Ilaris is a monoclonal antibody that is from a class of medicines called Interleukin-1 beta (IL-1β) blockers.
Ilaris (Canakinumab) is given as an injection under the skin (suBCUTAneous injection) 4 weekly, 8 weekly or 12 weekly, Depending on the condition being treated.
Ilaris became an FDA-approved medicine on June 18, 2009, originally to treat cryopyrin-associated periodic syndrome (CAPS), and since then more indications have been approved. On August 25, 2023, Ilaris becomes approved for gout flares in specific adults.
Ilaris side effects
Common Ilaris side effects
The most common side effects include:
Serious Ilaris side effects
Get emergency medical help if you have signs of an allergic reaction to Ilaris: hives; nausea, trouble swallowing; dizziness, fast or pounding heartbeats, difficult breathing; swelling of your face, lips, tongue, or throat.
Serious and sometimes fatal infections may occur during treatment with Ilaris. Call your doctor right away if you have signs of infection such as:
This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Ilaris
You should not use Ilaris if you are allergic to canakinumab.
Tell your doctor if you have ever had tuberculosis, if anyone in your household has tuberculosis, or if you have recently traveled to an area where tuberculosis is common.
To make sure Ilaris is safe for you, tell your doctor if you have ever had:
Make sure that you are current on all vaccines before you begin treatment with Ilaris. You should not receive ‘live’ vaccines while you are being treated with this medicine until your healthcare provider tells you that your immune system is no longer weakened.
Treatment with Ilaris may increase your risk of developing cancer. Talk to your doctor about your individual risk.
Pregnancy
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if Ilaris will harm your unborn baby. Tell your healthcare provider right away if you become pregnant while receiving this medicine.
If you use Ilaris while you are pregnant, make sure any doctor caring for your new baby knows that you used the medicine during pregnancy. Being exposed to Ilaris in the womb could affect your baby's vaccination schedule during the first 12 months of life.
Breastfeeding
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. Talk to your healthcare provider about the best way to feed your baby if you receive Ilaris.
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How to use Ilaris
Ilaris is given as an injection under the skin (subcutaneous injection) by a healthcare provider.
Ilaris is usually given:
Before you start treatment with Ilaris, your doctor may perform tests to make sure you do not have tuberculosis or other infections.
Tell your doctor if you have any changes in weight. Canakinumab doses are based on weight (especially in children and teenagers), and any changes may affect the dose.
Ilaris can weaken your immune system. Your blood may need to be tested often.
Click the link below for more detailed dosing information.
Warnings
Serious and sometimes fatal infections may occur during treatment with Ilaris. Call your doctor right away if you have signs of infection such as fever, chills, sweating, tiredness, cough, shortness of breath, skin sores, warm or painful areas on your body, diarrhea, stomach pain, or weight loss.
Your healthcare provider should test you for tuberculosis (TB) before you receive this medicine and monitor you closely for symptoms of TB during treatment.
Macrophage activation syndrome (MAS) is a syndrome associated with Still’s disease and some other autoinflammatory diseases like HIDS/MKD that can lead to death. Tell your healthcare provider right away if your AOSD or SJIA symptoms get worse or if you have any of these symptoms of an infection:
What other drugs will affect Ilaris
Sometimes it is not safe to use certain medications at the SAMe time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Tell your doctor about all your other medicines, especially:
This list is not complete. Other drugs may interact wth canakinumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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