Imipenem, cilastatin, and relebactam

Generic name: Imipenem, Cilastatin, And Relebactam
Brand names: Recarbrio
Dosage form: intravenous powder for injection (1.25 g)
Drug class: Carbapenems / beta-lactamase inhibitors

Usage of Imipenem, cilastatin, and relebactam

Imipenem, cilastatin, and relebactam is a combination medicine that is used to treat complicated infections of the urinary tract (bladder and kidneys) or infections within the stomach area (abdomen).

Imipenem, cilastatin, and relebactam is also used to treat pneumonia (a lung infection) caused by being in a hospital or using a ventilator.

imipenem, cilastatin, and relebactam is for use in adults who have few or no other treatment options.

Imipenem, cilastatin, and relebactam may also be used for purposes not listed in this medication guide.

Imipenem, cilastatin, and relebactam side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Imipenem, cilastatin, and relebactam may cause serious side effects. Call your doctor at once if you have:

tremors;

a seizure; or

severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose).

Common side effects of imipenem, cilastatin, and relebactam may include:

increased blood pressure;

nausea, diarrhea, vomiting;

abnormal liver function tests;

fever;

headache; or

pain, bruising, swelling, or irritation where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Imipenem, cilastatin, and relebactam

You should not be treated with imipenem, cilastatin, and relebactam if you are allergic to imipenem, cilastatin, or relebactam.

Tell your doctor if you have ever had:

a seizure;

a stroke; or

an allergic reaction to penicillin or other antibiotic medicines.

Tell your doctor if you are pregnant or breastfeeding.

Relate drugs

How to use Imipenem, cilastatin, and relebactam

Usual Adult Dose for Nosocomial Pneumonia:

1.25 g IV every 6 hours for 4 to 14 daysUses: For the treatment of patients with hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia due to susceptible Acinetobacter calcoaceticus-baumannii complex, Enterobacter cloacae, EscheriChia coli, Haemophilus influenzae, KlebsiElla aerogenes, K oxytoca, K pneumoniae, Pseudomonas aeruginosa, and Serratia marcescens

Usual Adult Dose for Pyelonephritis:

1.25 g IV every 6 hours for 4 to 14 daysComments:-Approval of this indication based on limited clinical safety and efficacy data for this drug.Use: In patients with limited or no alternative treatment options, for the treatment of complicated urinary tract infections (including pyelonephritis) due to susceptible E cloacae, E coli, K aerogenes, K pneumoniae, and P aeruginosa

Usual Adult Dose for Urinary Tract Infection:

Usual Adult Dose for Intraabdominal Infection:

1.25 g IV every 6 hours for 4 to 14 daysComments:-Approval of this indication based on limited clinical safety and efficacy data for this drug.Use: In patients with limited or no alternative treatment options, for the treatment of complicated intraabdominal infections due to susceptible Bacteroides caccae, B fragilis, B ovatus, B stercoris, B thetaiotaomicron, B uniformis, B vulgatus, Citrobacter freundii, E cloacae, E coli, Fusobacterium nucleatum, K aerogenes, K oxytoca, K pneumoniae, Parabacteroides distasonis, and P aeruginosa

Warnings

Diarrhea may be a sign of a new infection. Call your doctor if you have diarrhea that is watery or has blood in it.

What other drugs will affect Imipenem, cilastatin, and relebactam

Tell your doctor about all your other medicines, especially:

divalproex sodium;

ganciclovir; or

valproic acid.

This list is not complete. Other drugs may affect imipenem, cilastatin, and relebactam, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.