Inapsine

Generic name: Droperidol
Drug class: Miscellaneous central nervous system agents

Usage of Inapsine

Droperidol injection is used to prevent the nausea and vomiting that may occur after surgery or diagnostic procedures.

This medicine is to be given only by or under the direct supervision of your doctor.

Inapsine side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  • Blurred vision
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • sweating
  • unusual tiredness or weakness

    • Less common

  • Chills
  • cough
  • difficulty with breathing
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • noisy breathing
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • skin rash, hives, or itching
  • tightness in the chest

    • Incidence not known

  • Chest pain or discomfort
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • irregular or slow heart rate
  • low blood pressure or pulse
  • severe confusion or loss of consciousness

    • Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

    More common

  • Anxiety
  • drowsiness
  • restlessness
  • trouble sitting still

    • Incidence not known

  • Difficulty with speaking
  • drooling
  • loss of balance control
  • muscle trembling, jerking, or stiffness
  • seeing, hearing, or feeling things that are not there
  • shuffling walk
  • stiffness of the limbs
  • twisting movements of the body
  • uncontrolled movements, especially of the face, neck, and back

    • Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

    Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

    Before taking Inapsine

    In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

    Allergies

    Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

    Pediatric

    Appropriate studies have not been performed on the relationship of age to the effects of droperidol injection in children younger than 2 years of age. Safety and efficacy have not been established.

    Geriatric

    No information is available on the relationship of age to the effects of droperidol injection in geriatric patients. However, elderly patients are more likely to have age-related heart or kidney problems, which may require caution and an adjustment in the dose for patients receiving droperidol injection.

    Breast Feeding

    There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

    Interactions with Medicines

    Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

    Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Acetophenazine
  • Bepridil
  • Bromperidol
  • Cisapride
  • Clozapine
  • Dronedarone
  • Levoketoconazole
  • Levomethadyl
  • Mesoridazine
  • Molindone
  • Perphenazine
  • Pimozide
  • Pipamperone
  • Piperaquine
  • Remoxipride
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Tiapride
  • Triflupromazine
  • Ziprasidone

    • Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acecainide
  • Acetazolamide
  • Adagrasib
  • Ajmaline
  • Alfentanil
  • Alfuzosin
  • Alprazolam
  • Amiloride
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Amlodipine
  • Amoxapine
  • Anagrelide
  • Apomorphine
  • Aprindine
  • Aranidipine
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Arsenic Trioxide
  • Artemether
  • Asenapine
  • Astemizole
  • Atazanavir
  • Azimilide
  • Azithromycin
  • Azosemide
  • Bedaquiline
  • Bemetizide
  • Bendroflumethiazide
  • Benzhydrocodone
  • Benzthiazide
  • Bretylium
  • Brofaromine
  • Bromazepam
  • Bumetanide
  • Buprenorphine
  • Bupropion
  • Buserelin
  • Butorphanol
  • Calcium Oxybate
  • Cannabidiol
  • Cannabis
  • Canrenoate
  • Castor Oil
  • Ceritinib
  • Cetirizine
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Chlorthalidone
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clobazam
  • Clofazimine
  • Clomipramine
  • Clonazepam
  • Clopamide
  • Clorgyline
  • Clothiapine
  • Codeine
  • Crizotinib
  • Cyclobenzaprine
  • Cyclothiazide
  • Dabrafenib
  • Daridorexant
  • Dasatinib
  • Degarelix
  • Delamanid
  • Desipramine
  • Deslorelin
  • Deutetrabenazine
  • Dexmedetomidine
  • Dibenzepin
  • Dihydrocodeine
  • Diltiazem
  • Disopyramide
  • Docusate
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Doxepin
  • Doxylamine
  • Ebastine
  • Efavirenz
  • Encainide
  • Encorafenib
  • Enflurane
  • Entrectinib
  • Epinephrine
  • Erythromycin
  • Escitalopram
  • Esketamine
  • Ethacrynic Acid
  • Etozolin
  • Etrasimod
  • Felodipine
  • Fendiline
  • Fenquizone
  • Fentanyl
  • Fexinidazole
  • Fingolimod
  • Flecainide
  • Flibanserin
  • Fluconazole
  • Flunarizine
  • Fluoxetine
  • Fluspirilene
  • Fluvoxamine
  • Formoterol
  • Foscarnet
  • Fostemsavir
  • Furazolidone
  • Furosemide
  • Gabapentin
  • Gabapentin Enacarbil
  • Gallopamil
  • Gatifloxacin
  • Gemifloxacin
  • Gepirone
  • Glasdegib
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Halothane
  • Histrelin
  • Hydrochlorothiazide
  • Hydrocodone
  • Hydroflumethiazide
  • Hydromorphone
  • Hydroquinidine
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Indapamide
  • Inotuzumab Ozogamicin
  • Iproniazid
  • Isocarboxazid
  • Isoflurane
  • Isradipine
  • Ivabradine
  • Ivosidenib
  • Ketamine
  • Ketoconazole
  • Lacidipine
  • Lacosamide
  • Lactulose
  • Lapatinib
  • Lazabemide
  • Lefamulin
  • Lemborexant
  • Lenvatinib
  • Leuprolide
  • Levocetirizine
  • Levofloxacin
  • Levorphanol
  • Lidoflazine
  • Linezolid
  • Lithium
  • Lofexidine
  • Lopinavir
  • Lorcainide
  • Loxapine
  • Lumefantrine
  • Macimorelin
  • Magnesium Oxybate
  • Mannitol
  • Mefloquine
  • Meperidine
  • Methadone
  • Metoclopramide
  • Metolazone
  • Metronidazole
  • Mianserin
  • Mibefradil
  • Mifepristone
  • Mirtazapine
  • Mobocertinib
  • Moclobemide
  • Morphine
  • Morphine Sulfate Liposome
  • Moxifloxacin
  • Nafarelin
  • Nalbuphine
  • Nefazodone
  • Nialamide
  • Nicardipine
  • Nilotinib
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Ondansetron
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Oxycodone
  • Oxymorphone
  • Ozanimod
  • Pacritinib
  • Paliperidone
  • Panobinostat
  • Pargyline
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Pentazocine
  • Periciazine
  • Phenelzine
  • Phenobarbital
  • Pimavanserin
  • Piretanide
  • Pirmenol
  • Pitolisant
  • Polythiazide
  • Ponesimod
  • Posaconazole
  • Potassium Oxybate
  • Prajmaline
  • Pregabalin
  • Primidone
  • Probucol
  • Procainamide
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinethazone
  • Quinidine
  • Quinine
  • Quizartinib
  • Ranolazine
  • Rasagiline
  • Relugolix
  • Remifentanil
  • Remimazolam
  • Ribociclib
  • Risperidone
  • Ritanserin
  • RoPeginterferon Alfa-2b-njft
  • Selegiline
  • Selpercatinib
  • Sematilide
  • Sertindole
  • Sertraline
  • Sevoflurane
  • Sibutramine
  • Siponimod
  • Sodium Oxybate
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sorbitol
  • Sotalol
  • Spiramycin
  • Spironolactone
  • Sufentanil
  • Sulfamethoxazole
  • Sulpiride
  • Sultopride
  • Sunitinib
  • Tacrolimus
  • Tapentadol
  • Tedisamil
  • Telavancin
  • Telithromycin
  • Tetrabenazine
  • Ticrynafen
  • Toloxatone
  • Topiramate
  • Toremifene
  • Torsemide
  • Tramadol
  • Tranylcypromine
  • Trazodone
  • Triamterene
  • Trichlormethiazide
  • Triclabendazole
  • Trifluoperazine
  • Trimethoprim
  • Trimipramine
  • Triptorelin
  • Urea
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Vilanterol
  • Vinflunine
  • Voclosporin
  • Voriconazole
  • Xipamide
  • Zimeldine
  • Zolmitriptan
  • Zolpidem
  • Zotepine
  • Zuclopenthixol
  • Zuranolone

    • Interactions with Food/Tobacco/Alcohol

    Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

    Other Medical Problems

    The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bradycardia (slow heartbeat) or
  • Cardiac hypertrophy (heart is larger than normal) or
  • Congestive heart failure or
  • Heart disease or
  • Hypokalemia (low potassium in the blood) or
  • Hypomagnesemia (low magnesium in the blood) or
  • Pheochromocytoma (adrenal gland tumor)—May cause side effects to become worse.
  • Cardiac arrhythmias (abnormal heart beats) or
  • Hypotension (low blood pressure)—Use with caution. May make these conditions worse.
  • Congenital long QT syndrome (heart rhythm problem) or
  • QT prolongation (heart rhythm problem)—Should not be used in patients with these conditions.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

    • Relate drugs

    How to use Inapsine

    A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given as a shot into a muscle or a vein.

    Warnings

    Your doctor will check your progress after you receive this medicine. This will allow your doctor to see if the medicine is working properly and to check for unwanted effects.

    Tell your doctor right away if you have any change in your heart rhythm. The symptoms may include feeling dizzy or faint, or having a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.

    Check with your doctor right away if you have difficulty breathing, a fast heartbeat, a high fever, a change in blood pressure, increased sweating, loss of bladder control, severe muscle stiffness, unusually pale skin, or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).

    Droperidol will add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates or other seizure medicines; and muscle relaxants. Check with your doctor before taking any of these medicines after you receive droperidol.

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