Inderal (Propranolol Oral)

Generic name: Propranolol

Usage of Inderal (Propranolol Oral)

Propranolol is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure may reduce the risk of stroke and heart attacks.

Propranolol is also used to treat severe chest pain (angina), migraine headaches, or hypertrophic subaortic stenosis (thickened heart muscle).

This medicine may also be used to treat irregular heartbeats, tremors, or pheochromocytoma (adrenal gland tumor). It may also be used to reduce the risk of death in patients who have heart attacks.

Propranolol oral solution is used to treat proliferating infantile hemangioma.

This medicine is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart.

This medicine is available only with your doctor's prescription.

Inderal (Propranolol Oral) side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

- in children

Chest tightness

cough producing mucus

difficulty with breathing

Incidence not known

Black, tarry stools

blistering, peeling, or loosening of the skin

blood in the urine

bloody nose

bloody stools

blurred or loss of vision

body aches or pain

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain or discomfort

confusion about identity, place, and time

congestion

constipation

cough

cracks in the skin

crying

decreased awareness or responsiveness

decreased urine output

depersonalization

diarrhea

difficulty with swallowing

dilated neck veins

disturbed color perception

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

double vision

dryness or soreness of the throat

dysphoria

euphoria

fast, pounding, slow, or irregular heartbeat

fever and chills

general feeling of discomfort, illness, or weakness

hair loss

halos around lights

headaches

heavier menstrual periods

hoarseness

irregular breathing

lightheadedness, dizziness, or fainting

loss of heat from the body

mental depression

mimicry of speech or movements

muscle or joint pain

mutism

nausea

negativism

night blindness

noisy breathing

overbright appearance of lights

paleness or cold feeling in the fingertips and toes

paranoia

peculiar postures or movements, mannerisms, or grimacing

pinpoint red or purple spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

quick to react or overreact emotionally

rapidly changing moods

rectal bleeding

red skin lesions, often with a purple center

red, irritated eyes

red, swollen skin

reddening of the skin, especially around the ears

runny nose

scaly skin

seeing, hearing, or feeling things that are not there

severe sleepiness

short-term memory loss

skin irritation or rash, including rash that looks like psoriasis

skin rash, hives, or itching

stomach pain and tenderness

sores, ulcers, or white spots in the mouth or on the lips

sweating

swelling of the eyes, face, fingers, feet, or lower legs

swollen glands

tender, swollen glands in the neck

tingling or pain in fingers or toes when exposed to cold

tunnel vision

unusual bleeding or bruising

unusual tiredness or weakness

voice changes

vomiting

weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

- in children

Anxiety

dry mouth

hyperventilation

irritability

restlessness

shaking

sleepiness or unusual drowsiness

trouble sleeping

unusual dreams

Less common

- in children

Decreased appetite

Incidence not known

Dry eyes

heartburn

loss of strength or energy

muscle weakness

pain or discomfort in the chest, upper stomach, or throat

stomach cramps

unusual drowsiness, dullness, or feeling of sluggishness

vivid dreams

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Inderal (Propranolol Oral)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of propranolol capsules, extended-release capsules, and tablets in the pediatric population. Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of propranolol oral solution in children.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of propranolol oral solution to treat proliferating infantile hemangioma in children 5 weeks to 5 months of age. However, safety and efficacy have not been established in children older than 1 year of age.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of propranolol in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving propranolol.

No information is available on the relationship of age to the effects of propranolol oral solution in geriatric patients.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Rizatriptan

Thioridazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abametapir

Albuterol

Bupivacaine

Bupivacaine Liposome

Bupropion

Capmatinib

Ceritinib

Clonidine

Crizotinib

Darunavir

Desvenlafaxine

Diatrizoate

Diltiazem

Dronedarone

Epinephrine

Escitalopram

Eslicarbazepine Acetate

Fedratinib

Fenoldopam

Fexinidazole

Fingolimod

Fluoxetine

Formoterol

Haloperidol

Indacaterol

Iobenguane I 131

Iohexol

Lacosamide

Lercanidipine

Levalbuterol

Lidocaine

Mefloquine

Mepivacaine

Olodaterol

Oxymetazoline

Pixantrone

Ponesimod

Prilocaine

Rivastigmine

Salmeterol

Simeprevir

Siponimod

Sparsentan

Terbutaline

Venlafaxine

Verapamil

Vilanterol

Zileuton

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acarbose

Aceclofenac

Acemetacin

Acetyldigoxin

Albiglutide

Alfuzosin

Alogliptin

Aluminum Carbonate, Basic

Aluminum Hydroxide

Aluminum Phosphate

Amtolmetin Guacil

Aspirin

Bromfenac

Bufexamac

Bunazosin

Calcium Carbonate

Canagliflozin

Celecoxib

Chlorpromazine

Chlorpropamide

Cholestyramine

Choline Salicylate

Cimetidine

Clonixin

Dapagliflozin

Deslanoside

Dexibuprofen

Dexketoprofen

Diclofenac

Diflunisal

Digitoxin

Digoxin

Dihydroergotamine

Dihydroxyaluminum Aminoacetate

Dihydroxyaluminum Sodium Carbonate

Dipyrone

Doxazosin

Droxicam

Dulaglutide

Empagliflozin

Ergotamine

Ertugliflozin

Etodolac

Etofenamate

Etoricoxib

Exenatide

Felbinac

Fenoprofen

Fepradinol

Feprazone

Flecainide

Floctafenine

Flufenamic Acid

Flurbiprofen

Fluvoxamine

Glimepiride

Glipizide

Glyburide

Ibuprofen

Indomethacin

Insulin Aspart, Recombinant

Insulin degludec

Insulin Detemir

Insulin glargine, Recombinant

Insulin Glulisine

Insulin Human Inhaled

Insulin Human Isophane (NPH)

Insulin Human Regular

Insulin Lispro, Recombinant

Ketoprofen

Ketorolac

Linagliptin

Liraglutide

Lixisenatide

Lornoxicam

Loxoprofen

Lumiracoxib

Magaldrate

Meclofenamate

Mefenamic acid

Meloxicam

Metformin

Metildigoxin

Miglitol

Morniflumate

Moxisylyte

Nabumetone

Naproxen

Nateglinide

Nepafenac

Niflumic Acid

Nimesulide

Nimesulide Beta Cyclodextrin

Oxaprozin

Oxyphenbutazone

Parecoxib

Phenoxybenzamine

Phentolamine

Phenylbutazone

Piketoprofen

Pioglitazone

Piroxicam

Pramlintide

Pranoprofen

Prazosin

Proglumetacin

Propyphenazone

Proquazone

Quinidine

Repaglinide

Rifapentine

Rofecoxib

Rosiglitazone

Salicylic Acid

Salsalate

Saxagliptin

Sitagliptin

Sodium Salicylate

St John's Wort

Sulindac

Tamsulosin

Tenoxicam

Terazosin

Tiaprofenic Acid

Tolazamide

Tolbutamide

Tolfenamic Acid

Tolmetin

Trimazosin

Urapidil

Valdecoxib

Vildagliptin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Tobacco

How to use Inderal (Propranolol Oral)

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Your dose may need to be changed several times in order to find out what works best for you.

This medicine should come with a Medication Guide and patient directions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the long-acting oral capsules and tablets whole. Do not break, chew, crush, or open them.

Propranolol extended-release capsules should be taken at bedtime (10 pm). This medicine may be taken with or without food. However, you should take it the same way each time.

Measure the concentrated oral solution, Intensol™ with the dropper that comes with the package. You may mix the concentrated solution with water, juice, soda, applesauce, or pudding to make it easier to swallow, then take the mixture right away.

Measure the oral liquid with the dosing syringe that comes with the package. It should be given directly into the child's mouth, during or right after eating or breastfeeding. It may also be mixed with a small amount of milk or fruit juice and given with a baby's bottle. Do not shake before use.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take Depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For acute heart attack:

For oral dosage form (solution):

Adults—180 to 240 milligrams (mg) per day, given in divided doses.

Children—Dose is based on body weight and must be determined by your doctor.

For oral dosage form (tablets):

Adults—At first, 40 milligrams (mg) three times a day. Your doctor may increase your dose as needed.

Children—Use and dose must be determined by your doctor.

For adrenal gland tumor (pheochromocytoma):

For oral dosage form (solution):

Adults—60 milligrams (mg) per day, given in divided doses for 3 days before having surgery. In patients who cannot have surgery, the usual dose is 30 mg per day, given in divided doses.

Children—Dose is based on body weight and must be determined by your doctor.

For oral dosage form (tablets):

Adults—60 milligrams (mg) per day, given in divided doses for 3 days before having surgery. In patients who cannot have surgery, the usual dose is 30 mg per day, given in divided doses.

Children—Use and dose must be determined by your doctor.

For chest pain (angina):

For oral dosage form (long-acting oral capsules):

Adults—At first, 80 milligrams (mg) once a day. Your doctor may increase your dose as needed. The dose is usually not more than 320 mg per day.

Children—Use and dose must be determined by your doctor.

For oral dosage form (solution):

Adults—80 to 320 milligrams (mg) per day, given in divided doses.

Children—Dose is based on body weight and must be determined by your doctor.

For oral dosage form (tablets):

Adults—80 to 320 milligrams (mg) per day, given in divided doses.

Children—Use and dose must be determined by your doctor.

For high blood pressure (hypertension):

For oral dosage form (extended-release capsules):

Adults—At first, 80 milligrams (mg) once a day, given at bedtime. Your doctor may increase your dose as needed. However, the dose is usually not more than 120 mg per day.

Children—Use and dose must be determined by your doctor.

For oral dosage form (long-acting oral capsules):

Adults—At first, 80 milligrams (mg) once a day. Your doctor may increase your dose as needed.

Children—Use and dose must be determined by your doctor.

For oral dosage form (solution):

Adults—At first, 40 milligrams (mg) two times a day. Your doctor may increase your dose as needed.

Children—Dose is based on body weight and must be determined by your doctor.

For oral dosage form (tablets):

Adults—At first, 40 milligrams (mg) two times a day. Your doctor may increase your dose as needed.

Children—Use and dose must be determined by your doctor.

For hypertrophic subaortic stenosis (thickened heart muscle):

For oral dosage form (long-acting oral capsules):

Adults—80 to 160 milligrams (mg) once a day.

Children—Use and dose must be determined by your doctor.

For oral dosage form (solution):

Adults—20 to 40 milligrams (mg) three or four times a day, given before meals and at bedtime.

Children—Dose is based on body weight and must be determined by your doctor.

For oral dosage form (tablets):

Adults—20 to 40 milligrams (mg) three or four times a day, given before meals and at bedtime.

Children—Use and dose must be determined by your doctor.

For irregular heartbeats:

For oral dosage form (solution):

Adults—10 to 30 milligrams (mg) three or four times a day, given before meals and at bedtime.

Children—Dose is based on body weight and must be determined by your doctor.

For oral dosage form (tablets):

Adults—10 to 30 milligrams (mg) three or four times a day, given before meals and at bedtime.

Children—Use and dose must be determined by your doctor.

For migraine headaches:

For oral dosage form (long-acting oral capsules):

Adults—At first, 80 milligrams (mg) once a day. Your doctor may increase your dose as needed. The dose is usually not more than 240 mg per day.

Children—Use and dose must be determined by your doctor.

For oral dosage form (solution):

Adults—At first, 80 milligrams (mg) per day, given in divided doses. Your doctor may increase your dose as needed.

Children—Dose is based on body weight and must be determined by your doctor.

For oral dosage form (tablets):

Adults—At first, 80 milligrams (mg) per day, given in divided doses. Your doctor may increase your dose as needed.

Children—Use and dose must be determined by your doctor.

For proliferating infantile hemangioma:

For oral dosage form (solution):

Children 5 weeks to 5 months of age—Dose is based on your child's body weight and must be determined by the doctor. The starting dose is usually 0.6 milligram (mg) (0.15 milliliters [mL]) per kilogram (kg) of your child's body weight 2 times a day, taken at least 9 hours apart. Give the dose during or immediately after a feeding. Do not administer the dose if the infant is vomiting or not eating. After 1 week, the doctor will increase the dose to 1.1 mg (0.3 mL) per kg of body weight two times a day. After 2 weeks, the doctor will increase the dose to 1.7 mg (0.4 mL) per kg of body weight 2 times a day, taken for 6 months.

Children under 5 weeks of age—Use is not recommended.

For tremors:

For oral dosage form (solution):

Adults—At first, 40 milligrams (mg) two times a day. Your doctor may increase your dose as needed.

Children—Dose is based on body weight and must be determined by your doctor.

For oral dosage form (tablets):

Adults—At first, 40 milligrams (mg) two times a day. Your doctor may increase your dose as needed.

Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Throw away any unused Hemangeol® after 2 months.

Warnings

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects. .

Hemangeol® may increase the risk of heart or blood vessel problems (eg, bradycardia, hypotension). Check with your doctor right away if your child has blurred vision, chest pain or discomfort, confusion, lightheadedness, dizziness, or fainting, slow or uneven heartbeat, sweating, trouble breathing, or unusual tiredness or weakness.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Serious skin reactions can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loose skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using this medicine.

Propranolol may cause heart failure in some patients. Check with your doctor right away if you are having chest pain or discomfort, dilated neck veins, extreme fatigue, irregular breathing, an irregular heartbeat, swelling of the face, fingers, feet, or lower legs, or weight gain.

This medicine may cause changes in your blood sugar levels. Also, this medicine may cover up signs of low blood sugar, including rapid pulse rate. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests. Call your doctor right away if you have anxiety, blurred vision, chills, cold sweats, coma, confusion, cool, pale skin, depression, dizziness, fast heartbeat, headache, increased hunger, nausea, nervousness, nightmares, seizures, shakiness, slurred speech, or unusual tiredness or weakness.

Make sure any doctor or dentist who treats you knows that you are using this medicine. Do not stop taking this medicine before surgery without your doctor's approval.

This medicine may cause some people to become less alert than they are normally. If this side effect occurs, do not drive, use machines, or do anything else that could be dangerous if you are not alert while taking propranolol.

Do not interrupt or suddenly stop taking this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are taking before stopping it completely. Some conditions may become worse when the medicine is stopped suddenly, which can be dangerous.

Propranolol will add to the effects of alcohol and other central nervous system (CNS) depressants. CNS depressants are medicines that slow down the nervous system and may cause drowsiness. Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds, sedatives, tranquilizers, or sleeping medicine, prescription pain medicine or narcotics, barbiturates or medicine for seizures, muscle relaxants, or anesthetics, including some dental anesthetics. Check with your doctor before taking any of these medicines while you are using this medicine.

This medicine may increase risk of stroke in PHACE syndrome patients with severe blood vessel problems in the brain. Talk to your child's doctor about this risk.

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.

Some men who use this medicine may cause erectile dysfunction. Check with your doctor right away if you have decreased interest in sexual intercourse, inability to have or keep an erection, or loss in sexual ability, drive, or performance. If you have questions about this, talk to your doctor.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Inderal (Propranolol Oral)

Usage of Inderal (Propranolol Oral)

Inderal (Propranolol Oral) side effects

Before taking Inderal (Propranolol Oral)

Allergies

Pediatric

Geriatric

Breast Feeding

Interactions with Medicines

Interactions with Food/Tobacco/Alcohol

Other Medical Problems

How to use Inderal (Propranolol Oral)

Dosing

Missed Dose

Storage

Warnings

Disclaimer

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