Inebilizumab

Generic name: Inebilizumab
Brand names: Uplizna
Dosage form: intravenous solution (cdon 100 mg/10 mL)
Drug class: Selective immunosuppressants

Usage of Inebilizumab

Inebilizumab is used in adults with a condition called neuromyelitis optica (NOO-roe-mye-LYE-tis OP-ti-ka) spectrum disorder (NMOSD), and who are positive for a certain antibody.

NMOSD, also called Devic's disease, is a central nervous system disorder that occurs when your immune system attacks cells in your eyes, spinal cord, or brain. NMOSD may cause vision loss, weakness or paralysis in your arms or legs, numbness or pain, uncontrollable vomiting or hiccups, or loss of bowel or bladder control.

Inebilizumab can help lower your risk of having these symptoms or developing a permanent disability.

Inebilizumab may also be used for purposes not listed in this medication guide.

Inebilizumab side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your caregiver if you feel drowsy, nauseated, feverish, or have a headache, skin rash, muscle pain, or trouble breathing.

Inebilizumab may cause a serious brain infection that can lead to disability or death. Call your doctor right away if you have problems with speech, thought, vision, or muscle movement. These symptoms may start gradually and get worse quickly.

Inebilizumab may cause serious side effects. Call your doctor at once if you have:

fever, chills, body aches;

stuffy nose, cough, sore throat;

pain or burning when you urinate;

urinating more than usual; or

right-sided upper stomach pain, vomiting, loss of appetite, yellowing of your skin or eyes, and not feeling well.

Your doses may be delayed or permanently discontinued if you have certain side effects.

Common side effects of inebilizumab may include:

painful urination; or

joint pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Inebilizumab

You should not be treated with inebilizumab if you have:

active hepatitis B;

active or untreated tuberculosis; or

a history of life-threatening reaction to an inebilizumab injection.

Tell your doctor if you think you have an infection, or if you have ever had:

hepatitis B (or if you are a carrier);

tuberculosis; or

if you have recently received or are scheduled to receive a vaccine.

Make sure you are current on all vaccines at least 4 weeks before you start treatment with inebilizumab.

Inebilizumab may harm an unborn baby. Use effective birth control to prevent pregnancy while using inebilizumab and for at least 6 months after your last dose.

If you use inebilizumab while you are pregnant, make sure any doctor caring for your new baby knows that you used this medicine during pregnancy. Being exposed to inebilizumab in the womb could affect your baby's vaccination schedule during the first few months of life.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Relate drugs

How to use Inebilizumab

Usual Adult Dose for Neuromyelitis Optica:

Initial dose: 300 mg intravenous infusion followed 2 weeks later by a second 300 mg intravenous infusion. Maintenance dose: Single 300 mg intravenous infusion every 6 months (starting 6 months from the first infusion). Comments:-Determine whether there is an active, clinically significant infection before each infusion and do not administer in the presence of an active infection.-Pre-medicate with a corticosteroid (methylprednisolone or equivalent), antihistamine (diphenhydramine or equivalent), and an anti-pyretic (acetaminophen or equivalent) before each infusion.-Observe the patient for at least one hour after the completion of the infusionUse: Neuromyelitis Optica Disorder Spectrum (NMOSD)

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What other drugs will affect Inebilizumab

Tell your doctor about all your other medicines, especially:

drugs that weaken the immune system such as cancer medicine, steroids, and medicines to prevent organ transplant rejection.

This list is not complete. Other drugs may affect inebilizumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.