Inqovi

Generic name: Cedazuridine And Decitabine
Drug class: Antineoplastic combinations

Usage of Inqovi

Inqovi contains a combination of Cedazuridine and decitabine.

Inqovi is a prescription medicine that is used to treat treat adults with myelodysplastic syndromes (MDS, including chronic myelomonocytic leukemia (CMML). Myelodysplastic syndromes are types of blood or bone marrow disorders.

It is not known if Inqovi is safe or effective in children..

Inqovi side effects

Get emergency medical help if you have signs of an allergic reaction to Inqovi: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

easy bruising, unusual bleeding, purple or red spots under your skin;

low red blood cells (anemia) - pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet;

low white blood cell counts - fever, mouth sores, skin sores, sore throat, cough, trouble breathing; or

signs of a lung infection - fever, chills, cough with mucus, chest pain, feeling short of breath.

Your treatments may be delayed or permanently discontinued if you have certain side effects.

Common Inqovi side effects may include:

fever, low blood cell counts;

bruising or bleeding;

abnormal liver function tests;

headache, dizziness, feeling tired;

swelling in your arms or legs;

muscle or joint pain;

painful mouth sores;

shortness of breath, lung infection;

nausea, loss of appetite;

diarrhea, constipation;

rash; or

cold symptoms such as stuffy nose, sneezing, cough, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Inqovi

To make sure Inqovi is safe for you, tell your doctor if you have ever had::

kidney disease; or

liver disease.

You may need to have a negative pregnancy test before starting this treatment.

Cedazuridine and decitabine can harm an unborn baby or cause birth defects if the mother or the father is using this medicine.

If you are a woman, do not use Inqovi if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.

If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.

Tell your doctor right away if a pregnancy occurs while either the mother or the father is using this medicine.

Inqovi may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because the medicine can harm an unborn baby.

You should not breastfeed while using Inqovi and for at least 2 weeks after your last dose.

Inqovi is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Inqovi

Usual Adult Dose for Myelodysplastic Syndrome:

1 tablet (containing 100 mg cedazuridine and 35 mg decitabine) orally once daily on Days 1 through 5 of each 28-day cycle for a minimum of 4 cycles until disease progression or unacceptable toxicity; a complete or partial response may take longer than 4 cycles Comments: -Consider administering antiemetics prior to each dose to minimize nausea and vomiting. Use: For myelodysplastic syndromes (MDS), including previously treated and untreated, de novo and secondary MDS with the following French-American-British subtypes (refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, and chronic myelomonocytic leukemia [CMML]) and intermediate-1, intermediate-2, and high-risk International Prognostic Scoring System groups

Warnings

Inqovi affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, cough, mouth sores, or unusual bleeding or bruising.

Do not give Inqovi to other people, even if they have the same symptoms that you have. It may harm them.

What other drugs will affect Inqovi

Other drugs may interact with cedazuridine and decitabine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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