Insulin glargine and lixisenatide

Generic name: Insulin Glargine And Lixisenatide
Brand names: Soliqua 100/33
Dosage form: subcutaneous solution (100 units-33 mcg/mL)
Drug class: Antidiabetic combinations

Usage of Insulin glargine and lixisenatide

Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Insulin glargine is a long-acting insulin that starts to work several hours after injection and keeps working evenly for 24 hours. Lixisenatide is a diabetes medicine that helps your pancreas produce insulin more efficiently.

Insulin glargine and lixisenatide is a combination medicine that is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes. insulin glargine and lixisenatide is not for treating type 1 diabetes.

Insulin glargine and lixisenatide may also be used for purposes not listed in this medication guide.

Insulin glargine and lixisenatide side effects

Get emergency medical help if you have signs of an allergic reaction: hives, itching, severe rash; rapid heartbeats; trouble swallowing; difficult breathing; feeling light-headed; swelling of your face, lips, tongue, or throat.

This medicine may cause serious side effects. Stop using this medicine and call your doctor at once if you have:

pancreatitis--severe pain in your upper stomach spreading to your back, nausea and vomiting;

low blood sugar--headache, hunger, sweating, irritability, dizziness, fast heart rate, and feeling anxious or shaky;

heart problems--swelling, rapid weight gain, feeling short of breath; or

low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.

Common side effects of insulin glargine and lixisenatide may include:

low blood sugar;

nausea, diarrhea;

headache; or

cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Insulin glargine and lixisenatide

You should not use this medicine if you are allergic to insulin or lixisenatide, or if:

you are having an episode of low blood sugar;

you also use a short-acting mealtime insulin; or

you also use lixisenatide (Adlyxin) or a medicine like lixisenatide (albiglutide, dulaglutide, exenatide, liraglutide, Byetta, Bydureon, Saxenda, Tanzeum, Trulicity, Victoza).

Tell your doctor if you have ever had:

pancreatitis or gallstones;

alcoholism;

problems digesting food;

heart failure;

liver or kidney disease;

low levels of potassium in your blood (hypokalemia); or

diabetic ketoacidosis (call your doctor for treatment).

Tell your doctor if you are pregnant or breastfeeding.

Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

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How to use Insulin glargine and lixisenatide

Usual Adult Dose for Diabetes Type 2:

Insulin glargine 100 units/lixisenatide 33 mcg per mL (100/33); dosage is expressed in insulin glargine unitsDISCONTINUE basal insulin or glucagon-like peptide-1 (GLP-1) receptor agonist prior to initiating this drug: -For Patients Naive to Basal Insulin or GLP-1 Receptor Agonist; Currently on a GLP-1 Receptor Agonist; or Currently Receiving Less Than 30 units per day of Basal Insulin: -Initial dose: 15 units suBCutaneously once a day For Patients Receiving 30 to 60 units of Basal Insulin With or Without a GLP-1 Receptor Agonist: -Initial dose: 30 units subcutaneously once a day TITRATE dose up or down in increments of 2 to 4 units/week based on metabolic needs, blood glucose monitoring results, and glycemic goal until desired fasting plasma glucose is achieved-Maintenance dose: 15 to 60 units per day-Maximum dose: Insulin glargine 60 units/lixisenatide 20 mcg once a dayComments:-Administer once a day within the hour prior to the first meal of the day. -This drug should be titrated until desired fasting plasma glucose is achieved. -Additional titration may be needed to minimize the risk of hypoglycemia or hyperglycemia (e.g., with changes in physical activity, diet or timing of food intake, during acute illness; or when used with other medications.Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Warnings

Stop using insulin glargine and lixisenatide and call your doctor at once if you have nausea and vomiting with severe pain in your upper stomach spreading to your back.

Never share an injection pen or syringe with another person, even if the needle has been changed.

What other drugs will affect Insulin glargine and lixisenatide

Tell your doctor if you also take pioglitazone or rosiglitazone (sometimes contained in combinations with glimepiride or metformin). Taking certain oral diabetes medicines while you are using insulin may increase your risk of serious heart problems.

Lixisenatide can make it harder for your body to absorb other medicines you take by mouth. If you take any of the following medicines, take them at least 1 hour before your insulin glargine and lixisenatide injection:

an antibiotic;

acetaminophen (Tylenol); or

birth control pills (take 1 hour before or 11 hours after your insulin glargine and lixisenatide injection).

Many other medicines can affect your blood sugar, and some medicines can increase or decrease the effects of insulin glargine and lixisenatide. Some drugs can also cause you to have fewer symptoms of hypoglycemia, making it harder to tell when your blood sugar is low. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products.

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