Insulin Human

Drug class: Antineoplastic Agents

Usage of Insulin Human

Diabetes Mellitus

Replacement therapy for the management of diabetes mellitus. Human insulin manufactured using recombinant DNA technology has replaced insulins of animal origin (no longer commercially available in the US).

Insulin is required in all patients with type 1 diabetes mellitus, and mandatory in the treatment of diabetic ketoacidosis and hyperosmolar hyperglycemic states.

Also used in patients with type 2 diabetes mellitus when weight reduction, proper dietary regulation, and/or oral antidiabetic agents have failed to maintain satisfactory glycemic control in both the fasting and postprandial state.

Diet should be emphasized as the primary form of treatment when initiating therapy for patients with type 2 diabetes mellitus who do not have severe symptoms; caloric restriction and weight reduction are essential in obese patients.

The American Diabetes Association (ADA) and many clinicians recommend the use of physiologically based, intensive insulin regimens (i.e., 3 or more insulin injections daily with dosage adjusted according to the results of multiple daily blood glucose determinations [e.g., at least 4 times daily], dietary intake, and anticipated exercise) in most type 1 and type 2 diabetic patients who are able to understand and carry out the treatment regimen, are not at increased risk for hypoglycemic episodes, and do not have other characteristics that increase risk or decrease benefit (e.g., advanced age, end-stage renal failure, advanced cardiovascular or cerebrovascular disease, other coexisting diseases that shorten life expectancy).

Goals of insulin therapy in all patients generally should include maintenance of blood glucose as close as possible to euglycemia without undue risk of hypoglycemia; avoidance of symptoms attributable to hyperglycemia, glycosuria, or ketonuria; and maintenance of ideal body weight and of normal growth and development in children.

Diabetic Ketoacidosis or Hyperosmolar Hyperglycemic States

Used in the emergency treatment of diabetic ketoacidosis or hyperosmolar hyperglycemic states when rapid control of hyperglycemia is required. Regular insulin (e.g., insulin human [regular], insulin [regular]) is the insulin of choice in the treatment of such emergency conditions because of its relatively rapid onset of action and because it can be administered IV.

Acute Stroke

Insulin injection (e.g., insulin human) also has been used IV in combination with IV potassium chloride and Dextrose (i.e., GIK therapy) in a limited number of patients with acute stroke† [off-label] and mild to moderate hyperglycemia.

Critical Illness

Has been used to reduce morbidity and mortality in patients with critical illness† [off-label] requiring intensive care.

Gestational Diabetes Mellitus

The ADA states that human insulin is preferred for use in pregnant women or women considering pregnancy. The ADA recommends that insulin therapy (using insulin human) be considered in patients with gestational diabetes who, despite dietary management, have fasting plasma glucose concentrations exceeding 105 mg/dL or 2-hour postprandial plasma glucose concentrations exceeding 130 mg/dL.

Relate drugs

How to use Insulin Human

General

  • Adjust dosage of insulin based on blood glucose determinations and carefully individualize to attain optimum therapeutic effect.
  • Because urine glucose concentrations correlate poorly with blood glucose values, urine glucose concentrations should be used only in patients who cannot (e.g., patients with severe neuropathies, severe vision impairment, Raynaud’s syndrome, paralysis, or those receiving anticoagulants) or will not test blood glucose concentrations.
  • Patients receiving conventional insulin regimens should self-monitor blood glucose concentrations with a frequency ranging from once or twice daily to several times weekly.
  • In patients receiving intensive insulin regimens, the decision to supplement or decrease the previous preprandial dose of short- or rapid-acting insulin is made on the basis of blood glucose determinations obtained before each preprandial insulin injection.

    • Transferring from Therapy with Other Insulins

  • Make any change in insulin preparation or dosage regimen with caution and only under medical supervision. Changes in purity, strength, brand, type, and/or method of manufacture may necessitate a change in dosage.
  • Not possible to clearly identify which patients will require a change in dosage when therapy with a different preparation is initiated. May need adjustments with the first dose or may occur over a period of several weeks.

    • Administration

    Insulin human (regular) and isophane insulin human suspension usually are administered sub-Q.

    May administer insulin human (regular) IM† [off-label] or IV for the treatment of diabetic ketoacidosis or hyperosmolar hyperglycemia. Insulin human (regular) is the only form of insulin human that may be administered IV.

    Do not administer isophane insulin human suspension IV.

    Sub-Q Administration

    Administer insulin human (regular) injection and isophane insulin human suspension usually by sub-Q injection.

    Avoid excessive agitation of the vial prior to withdrawing the insulin human regular dose since loss of potency, clumping, frosting, or precipitation may occur.

    Since suspensions contain insulin in the precipitate, gently agitate the vial to assure a homogeneous mixture for accurate measurement of each dose. Slowly rotate and invert or carefully shake the vial several times before withdrawal of each dose. Avoid vigorous shaking since frothing may interfere with correct measurement of a dose.

    Administer into the thighs, upper arms, buttocks, or abdomen using a 25- to 28-gauge needle, one-half to five-eighths inch in length.

    Most individuals should grasp a fold of skin lightly with the fingers at least 3 inches apart and insert the needle at a 90° angle; thin individuals or children may need to pinch the skin and inject at a 45° angle to avoid IM injection, especially in the thigh area.

    Routine aspiration to check for inadvertent intravascular injection generally is not necessary.

    Inject over a period of 2–4 seconds. Slow sub-Q injection of insulin suspensions may result in clogging of the tip of the needle.

    Press injection site lightly for a few seconds after the needle is withdrawn; do not rub.

    Rotate sites so that any one site is not injected more than once every 1–2 weeks.

    IV Administration

    For solution and drug compatibility information, see Compatibility under Stability.

    In general, reserve IV route for use in patients with circulatory collapse, diabetic ketoacidosis, hyperosmolar hyperglycemia, or hyperkalemia. Has also been administered by IV infusion for hyperglycemia associated with critical illness.

    Dilution

    For IV infusion, usually dilute insulin human (regular) injection in 0.9% sodium chloride injection.

    Dosage

    Dosage must be individualized.

    Patients receiving insulin should be monitored with regular laboratory evaluations, including blood glucose determinations and glycosylated hemoglobin (hemoglobin A1c [HbA1c]) concentrations, to determine the minimum effective dosage of insulin when used alone, with other insulins, or in combination with an oral antidiabetic agent.

    Pediatric Patients

    Diabetes Mellitus Sub-Q

    Children with newly diagnosed type 1 diabetes mellitus initially require total daily insulin dosage of 0.5–1 units/kg; requirement may be much lower during partial remission period. May need substantially higher daily dosage in severe insulin resistance (e.g., puberty, obesity).

    In patients with type 2 diabetes mellitus, initial total daily dosage ranges from 0.2–0.4 units/kg.

    Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic States IV

    In children and adolescents <20 years of age, the ADA recommends initially an IV infusion of regular insulin at a rate of 0.1 units/kg per hour. An initial direct IV injection of regular insulin is not recommended in such patients.

    IM† [off-label], then Sub-Q

    If IV access is unavailable, regular insulin may be given IM in an initial dose of 0.1 units/kg, followed by 0.1 units/kg per hour sub-Q or IM until acidosis is resolved (i.e., venous pH >7.3, serum bicarbonate concentration >15 mEq/L).

    Dosage Following Resolution of Diabetic Ketoacidosis IV, then Sub-Q

    Upon resolution of ketoacidosis or the hyperosmolar state, the regular insulin IV infusion rate should be decreased to 0.05 units/kg per hour until sub-Q replacement insulin therapy is initiated.

    Initiate replacement therapy at an insulin dosage of 0.5–1 units/kg daily given sub-Q in divided doses ((2/3) of the daily dosage in the morning [(1/3) as short-acting insulin, (2/3) as intermediate-acting insulin] and (1/3) in the evening [½ as short-acting insulin, ½ as intermediate-acting insulin]). In pediatric patients with newly diagnosed diabetes mellitus, may administer 0.1–0.25 units/kg of regular insulin every 6–8 hours during the first 24 hours to determine insulin requirements.

    Adults

    Diabetes Mellitus Sub-Q

    Initial total daily insulin dosages in adults with type 1 diabetes mellitus range from 0.2–1 units/kg. May need substantially higher daily dosage in severe insulin resistance (e.g., obesity).

    In patients with type 2 diabetes mellitus, initial total daily dosage ranges from 0.2–0.4 units/kg.

    Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic States Mild Diabetic Ketoacidosis IV, then Sub-Q or IM† [off-label]

    For the treatment of mild diabetic ketoacidosis (plasma glucose >250 mg/dL with an arterial pH of 7.25–7.3 and serum bicarbonate of 15–18 mEq/L), the ADA recommends a loading dose of 0.4–0.6 units/kg of regular insulin administered in 2 doses, with 50% given by direct IV injection and 50% by sub-Q or IM injection. After the loading dose, administer 0.1 units/kg per hour of regular insulin sub-Q or IM.

    Moderate to Severe Diabetic Ketoacidosis IV

    For the treatment of moderate to severe diabetic ketoacidosis (plasma glucose >250 mg/dL with arterial pH ≤7–7.24 and serum bicarbonate ≤10–15 mEq/L) or hyperosmolar hyperglycemia in adults, the ADA recommends a loading dose of 0.15 units/kg of regular insulin by direct IV injection, followed by continuous IV infusion of 0.1 units/kg per hour.

    If plasma glucose concentrations do not fall by 50 mg/dL within the first hour of insulin therapy, insulin infusion rate may be doubled every hour, provided the patient is adequately hydrated, until plasma glucose decreases steadily by 50–75 mg/dL per hour.

    When a plasma glucose concentration of 250 or 300 mg/dL is achieved in patients with diabetic ketoacidosis or hyperosmolar hyperglycemia, respectively, may decrease the insulin infusion rate to 0.05–0.1 units/kg per hour. May need to adjust the rate of insulin administration or the concentration of dextrose to maintain glucose concentration until resolution of diabetic ketoacidosis (i.e., serum glucose <200 mg/dL, venous pH >7.3, serum bicarbonate ≥18 mEq/L) or hyperosmolar hyperglycemia (i.e., patient mentally alert, serum osmolality of ≤315 mOsm/kg).

    Dosage Following Resolution of Diabetic Ketoacidosis IV, then Sub-Q

    Upon resolution of diabetic ketoacidosis (i.e., plasma glucose <200 mg/dL, venous pH >7.3, serum bicarbonate ≥18 mEq/L) or hyperosmolar hyperglycemia in patients who are unable to eat, continue IV insulin and fluid replacement; may give sub-Q regular insulin as needed every 4 hours. May give regular insulin sub-Q in 5-unit increments for every 50-mg/dL increase in blood glucose concentrations above 150 mg/dL, to a dose of up to 20 units of regular insulin for a blood glucose of ≥300 mg/dL.

    When the patient is able to eat, initiate a multiple-dose, sub-Q insulin regimen consisting of a short- or rapid-acting insulin and an intermediate- or long-acting insulin. Continue regular insulin IV for 1–2 hours after initiation of the sub-Q insulin regimen to ensure adequate plasma insulin concentrations during the transition. Abrupt discontinuance of IV insulin with the institution of delayed-onset sub-Q insulin may lead to worsened glycemic control. Patients with known diabetes mellitus may reinstitute the insulin regimen they were receiving before the onset of hyperglycemic crises, and the regimen may be adjusted further as needed for adequate glycemic control.

    Patients with newly diagnosed diabetes mellitus should receive a total daily insulin dosage of 0.5–1 units/kg as part of a multiple-dose regimen of insulin, until an optimal dosage is established. May manage some patients with newly diagnosed type 2 diabetes mellitus with diet therapy and oral antidiabetic agents following resolution of hyperglycemic crises.

    Warnings

    Warnings/Precautions

    Warnings

    Hypoglycemia

    Care should be taken in patients who are most at risk for the development of these effects, including patients who are fasting or those with defective counterregulatory responses (e.g., patients with autonomic neuropathy, adrenal or pituitary insufficiency, those receiving β-adrenergic blocking agents). .

    Reduce the potential for late postprandial hypoglycemia by altering the timing, frequency, and content of meals; altering exercise patterns; frequently monitoring blood glucose concentrations; adjusting insulin dosage; and/or switching to a more rapid-acting insulin (i.e., insulin lispro).

    Use intensive insulin therapy with caution in patients with a history of hypoglycemic unawareness or recurrent, severe hypoglycemic episodes. Higher target blood glucose concentrations (e.g., fasting blood glucose concentrations of 140 mg/dL and 2-hour postprandial concentrations of 200–250 mg/dL) are advisable in these patients.

    Exercise extreme caution when concentrated (U-500) insulin human (regular) injection is used in patients with marked insulin resistance (i.e., daily insulin requirements >200 units). Inadvertent overdosage may result in irreversible insulin shock. Serious consequences may result if this concentrated injection is used without constant medical supervision.

    Sensitivity Reactions

    Local reactions (e.g., pain at injection site, erythema, pruritus, swelling) reported. Warming refrigerated insulin to room temperature prior to use will limit local irritation at the injection site.

    Generalized hypersensitivity reactions (e.g., rash, shortness of breath, wheezing, hypotension, tachycardia, diaphoresis) reported less frequently, but may be life-threatening. The incidence of allergic reactions may have decreased with the availability of more purified insulin (e.g., insulin human, insulin lispro).

    Insulin Resistance

    Chronic insulin resistance resulting from immunity has been decreased by changing to a purified insulin preparation (e.g., insulin human).

    General Precautions

    Lipodystrophy

    Atrophy or hypertrophy of suBCutaneous fat tissue may occur at sites of frequent insulin injections. Rotate injection site to reduce or prevent these effects.

    Hypokalemia

    Care should be taken in patients who are most at risk for the development of hypokalemia, such as those who are receiving potassium-lowering drugs.

    Since diabetic ketoacidosis often is associated with hypokalemia, the possibility of potassium imbalance should be evaluated and, if present, corrected before administration of insulin as long as adequate renal function is assured.

    Concurrent Illness

    Illness, particularly nausea and vomiting, and changes in eating patterns may alter insulin requirements.

    Use of Fixed Combinations

    When used in fixed combination with other agents, consider the cautions, precautions, and contraindications associated with the concomitant agents.

    Specific Populations

    Pregnancy

    Category B.

    Most clinicians recommend initiation of intensive insulin therapy (3 or more insulin injections daily with dosage adjusted according to results of at least 4 daily blood glucose determinations, dietary intake, and anticipated exercise) prior to conception in diabetic patients who are well controlled on oral hypoglycemic agents and who are considering pregnancy.

    Geriatric Use

    The safety of an intensive insulin regimen (3 or more insulin injections daily with dosage adjusted according to results of at least 4 daily blood glucose determinations, dietary intake, and anticipated exercise) in geriatric patients has been questioned. Increased incidence of hypoglycemia associated with intensive insulin therapy may increase the probability of strokes and heart attacks in such patients.

    Hypoglycemic reactions in geriatric diabetic patients may mimic a cerebrovascular accident. An increased incidence of macrovascular disease in geriatric patients with type 2 diabetes mellitus may make such patients more vulnerable to serious consequences of hypoglycemia (e.g., fainting, seizures, falls, stroke, silent ischemia, MI, sudden death).

    Common Adverse Effects

    Hypoglycemia.

    What other drugs will affect Insulin Human

    Specific Drugs

    Drugs That May Potentiate Hypoglycemic Effects
  • Alcohol
  • ACE inhibitors
  • Disopyramide
  • Fibrate derivatives
  • Fluoxetine
  • Guanethidine
  • MAO inhibitors
  • Oral antidiabetic agents
  • Propoxyphene
  • Salicylates
  • Somatostatin derivatives (e.g., octreotide)
  • Sulfa anti-infectives
    • Drugs That May Antagonize Hypoglycemic Effects
  • Calcium-channel blocker
  • Corticosteroids
  • Danazol
  • Diuretics
  • Estrogens and progestins (e.g., oral contraceptives)
  • Isoniazid
  • Niacin
  • Phenothiazines
  • Somatropin
  • Sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline)
  • Thyroid hormones
    • Drugs That May Have a Variable Effect on Glycemic Control
  • Alcohol
  • β-Adrenergic blocking agents
  • Clonidine
  • Lithium salts
  • Pentamidine
    • Drugs That May Reduce or Eliminate Signs of Hypoglycemia (Sympatholytic Agents)
  • β-Adrenergic blocking agents
  • Clonidine
  • Guanethidine
  • Reserpine

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