Invokana

Generic name: Canagliflozin
Drug class: SGLT-2 inhibitors

Usage of Invokana

Invokana is an oral diabetes medicine that helps control blood sugar levels. Canagliflozin works by helping the kidneys get rid of glucose from your bloodstream.

Invokana is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Invokana is also used to lower the risk of death from heart attack, stroke, or heart failure in adults with type 2 diabetes who also have heart disease.

Invokana is also used to reduce the risk of end-stage kidney disease and hospitalization or death from heart problems in adults who also have kidney problems caused by type 2 diabetes.

Invokana is not for treating type 1 diabetes.

Invokana side effects

Get emergency medical help if you have signs of an allergic reaction to Invokana: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Seek medical attention right away if you have signs of a genital infection (penis or vagina): burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, not feeling well. These symptoms may get worse quickly.

Call your doctor at once if you have:

a light-headed feeling, like you might pass out;

little or no urination;

pain or burning when you urinate;

new pain, tenderness, sores, ulcers, or infections in your legs or feet;

high potassium - nausea, irregular heartbeats, weakness, loss of movement;

ketoacidosis (too much acid in the blood) - nausea, vomiting, stomach pain, confusion, unusual drowsiness, or trouble breathing; or

dehydration symptoms - dizziness, weakness, feeling light-headed (like you might pass out).

You may be more likely to have a broken bone while using Invokana. Talk with your doctor about how to avoid the risk of fractures.

Side effects may be more likely to occur in older adults.

Common Invokana side effects may include:

genital infections; or

urinating more than usual.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Invokana

You should not use Invokana if you are allergic to canagliflozin, or if you have:

severe kidney disease (or if you are on dialysis).

Invokana may increase your risk of lower leg amputation, especially if you have had a prior amputation, a foot ulcer, heart disease, circulation problems, or nerve damage.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

heart problems;

a diabetic foot ulcer or amputation;

circulation problems or nerve problems in your legs or feet;

kidney disease;

liver disease;

bladder infections or other urination problems;

a pancreas disorder;

if you drink often, or drink large amounts of alcohol;

if you are eating less than usual; or

if you are on a low salt diet.

Follow your doctor's instructions about using this medicine if you are pregnant. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester.

You should not use canagliflozin during the second or third trimester of pregnancy.

You should not breast-feed while using this medicine.

Invokana is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Invokana

Usual Adult Dose for Diabetes Type 2:

Initial dose: 100 mg orally once a day -May increase to 300 mg orally once a day for additional glycemic control but only in patients who have tolerated lower dose and who have an eGFR of 60 mL/min/1.73 m2 or greater Maximum dose: 300 mg/day Comments: -Do not initiate in patients with an eGFR less than 45 mL/min/1.73 m2 as this drug will not be effective. -If used in combination with insulin or an insulin secretagogue, a lower dose of insulin or the insulin secretagogue should be considered to reduce the risk of hypoglycemia. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Warnings

You should not use Invokana if you have severe kidney disease or if you are on dialysis.

Invokana can cause serious infections in the penis or vagina. Get medical help right away if you have burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, or if you don't feel well.

What other drugs will affect Invokana

Tell your doctor about all your other medicines, especially:

insulin or other oral diabetes medicines;

a diuretic or "water pill";

digoxin, digitalis;

rifampin;

ritonavir; or

seizure medication - phenobarbital, phenytoin.

This list is not complete. Other drugs may interact with canagliflozin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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