Iodoquinol (Topical)

Drug class: Antineoplastic Agents , Antineoplastic Agents

Usage of Iodoquinol (Topical)

Dermatoses

Principally used in combination with hydrocortisone for the topical treatment of subacute and chronic dermatoses.

National Research Council and FDA state that iodoquinol/hydrocortisone combinations are “possibly” effective for topical treatment of eczema (e.g., impetiginized eczema, nummular eczema, infantile eczema, nuchal eczema) and dermatitis (e.g., contact, atopic, endogenous chronic infectious, stasis, localized or disseminated neurodermatitis). Also may be effective for treatment of bacterial dermatoses, mycotic dermatoses [e.g., tinea (capitis, cruris, corporis, pedis), pyoderma, chronic eczematoid otitis externa, acne urticata, lichen simplex chronicus, anogenital pruritus (vulvae, scroti, ani), folliculitis, moniliasis, and intertrigo. .

Has been used topically in a suitable dermatologic vehicle alone or in combination with coal tar† [off-label] in the treatment of bacterial and fungal infections of the skin.

Has been used in the treatment of diaper rash (diaper dermatitis); however, use in children currently is not recommended. (See Pediatric Use under Cautions.)

Seborrheic Dermatitis

Has been used as a shampoo (no longer commercially available in the US) for control of seborrheic dermatitis of the scalp† [off-label]; however, relapse usually occurs when the drug is discontinued.

Relate drugs

How to use Iodoquinol (Topical)

Administration

Topical Administration

Apply topically to the skin as a cream or gel.

For external use only; avoid contact with the eyes.

Do not use over large areas of skin for long periods.

Dosage

Adults

Dermatoses Topical

Apply combination cream or gel (iodoquinol 1% and hydrocortisone 1–2%) to affected area(s) 3 or 4 times daily as directed.

Prescribing Limits

Adults

Dermatoses Topical

Not recommended for prolonged use. (See Superinfection under Warnings.)

Special Populations

Geriatric Patients

Generally, select dosage with caution, usually initiating at the lower end of the usual range, because of age related decreases in hepatic, renal, and/or cardiac function and concomitant disease or drug therapy.

Warnings

Contraindications

  • Known hypersensitivity to iodoquinol or any ingredient in the formulation.
  • Iodine intolerance.

    • Warnings/Precautions

    Sensitivity Reactions

    Cross-sensitivity Reactions

    Cross-sensitivity may occur between halogenated hydroxyquinolines (e.g., clioquinol).

    General Precautions

    Topical Effects

    Possible local irritation (e.g., burning, itching, irritation, dryness). If irritation occurs, discontinue the drug and institute appropriate therapy.

    May stain skin and fabrics.

    Superinfection

    Possible overgrowth of nonsusceptible organisms with prolonged therapy. Institute appropriate therapy if superinfection occurs.

    Systemic Effects

    Adverse systemic effects may occur when fixed-combination preparation also containing hydrocortisone is used on large areas of the body or with occlusive dressing.

    Children may be more susceptible to adverse systemic effects. (See Use of Fixed Combinations and also Pediatric Use, under Cautions.)

    Use of Fixed Combinations

    When used topically in fixed combination with hydrocortisone, consider the usual cautions, precautions, and contraindications associated with topical corticosteroid therapy.

    Specific Populations

    Pregnancy

    Category C.

    Lactation

    Not known if distributed into milk. Use caution in nursing women.

    Pediatric Use

    Safety and efficacy not established in children <12 years of age.

    Use in pediatric patients currently is not recommended given the association between oculotoxic/neurotoxic effects (e.g., optic neuritis, optic atrophy, subacute myelo-optic neuropathy [SMON]) and oral therapy with halogenated hydroxyquinoline derivatives and the availability of effective alternative topical anti-infectives.

    Geriatric Use

    Clinical studies of fixed-combination iodoquinol and hydrocortisone cream did not include sufficient number of patients ≥65 years of age to determine whether geriatric patients respond differently than younger patients. Other reported clinical experience has not identified differences in responses between geriatric patients and younger patients.

    Common Adverse Effects

    Burning, itching, irritation, dry skin.

    What other drugs will affect Iodoquinol (Topical)

    Specific Tests

    Tests

    Interaction

    Comments

    Test, phenylketonuria (ferric chloride)

    May produce false-positive results when the drug is present in urine or the diaper

    Tests, thyroid function

    May interfere with certain thyroid function tests (e.g., protein-bound iodine)

    Allow ≥1 month between discontinuance of topical iodoquinol therapy and performance of tests

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