Ioflupane I-123

Generic name: Ioflupane I-123
Brand names: DaTscan
Dosage form: intravenous solution (74 MBq/mL)
Drug class: Diagnostic radiopharmaceuticals

Usage of Ioflupane I-123

Ioflupane I-123 is in a group of drugs called diagnostic radiopharmaceuticals (RAY dee oh far ma SOO tik als). Ioflupane I-123 is a radioactive agent that allows images of the brain to be detected by a gamma camera.

Ioflupane I-123 is used to detect brain signs of Parkinson's disease in people with symptoms such as tremors, loss of balance or coordination, shuffling walk, or other movement problems.

Ioflupane I-123 may also be used for purposes not listed in this medication guide.

Ioflupane I-123 side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives, itching, skin redness; difficult breathing; swelling of your face, lips, tongue, or throat.

Common side effects of ioflupane I-123 may include:

pain, swelling, burning, or irritation around the IV needle;

headache;

dizziness, spinning sensation;

dry mouth; or

nausea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Ioflupane I-123

You should not receive ioflupane I-123 if you are allergic to it. Tell your doctor if you have ever had any type of reaction to another contrast agent, or to iodine.

Tell your doctor if you have ever had:

a thyroid disorder;

kidney disease;

liver disease; or

if you have ever had an allergic reaction to potassium iodide or Lugol's Solution.

Older adults may need kidney function tests before receiving ioflupane I-123. Your kidney function may also need to be watched closely after you have received ioflupane I-123.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

You should not breastfeed within 6 days after using ioflupane I-123. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby.

Relate drugs

How to use Ioflupane I-123

Usual Adult Dose for Computed Tomography:

111 to 185 MBq (3 to 5 mCi) intravenously after administration of thyroid blocking agentThyroid Blocking Agent:-Administer Potassium Iodide Oral Solution or Lugol's Solution (equivalent to 100 mg iodide) or potassium perchlorate (400 mg) to block uptake of iodine 123 by the patient's thyroid at least 1 hour before using this drug.Comments:-Begin single photon emission computed tomography (SPECT) imaging 3 to 6 hours following administration of this drug.-Dosing is based upon the radioactivity determined using a suitably calibrated instrument immediately prior to administration.Uses:-Visualization of striatal dopamine transporter using SPECT brain imaging to assist in the evaluation of adult patients with suspected Parkinsonian syndromes (PS).-To help differentiate essential tremor from tremor due to PS (idiopathic Parkinson's disease, multiple system atrophy and progressive supranuclear palsy).-As an adjunct to other diagnostic evaluations.

Warnings

Before using ioflupane I-123 tell your doctor about all your medical conditions or allergies, all medicines you use, and if you are pregnant or breastfeeding.

What other drugs will affect Ioflupane I-123

Tell your doctor about all your other medicines, especially:

Buspirone;

a diet pill or stimulant medicine;

ADHD medications--amoxapine, amphetamine, methamphetamine, methylphenidate, Adderall, Ritalin, and others;

an antidepressant--Bupropion, citalopram, paroxetine, sertraline; or

medicine to treat Parkinson's disease--Benztropine, selegiline.

This list is not complete. Other drugs may affect ioflupane I-123, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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