Ipratropium (Systemic, Oral Inhalation)
Brand names: Atrovent
Drug class:
Antineoplastic Agents
Usage of Ipratropium (Systemic, Oral Inhalation)
Bronchospasm in COPD
Long-term treatment of reversible bronchospasm associated with COPD, including chronic bronchitis and emphysema.
Fixed combination with albuterol sulfate is used for the symptomatic management of bronchospasm associated with COPD in patients who continue to have evidence of bronchospasm despite the regular use of an orally inhaled bronchodilator and who require a second bronchodilator.
Bronchospasm in Asthma
Has been used for symptomatic treatment of acute or chronic bronChial asthma† [off-label]; β2-adrenergic agonist bronchodilators generally preferred initially for relief of bronchospasm in asthmatic patients.
May be useful as alternative therapy in adults experiencing adverse effects (e.g., tachycardia, arrhythmia, tremor) with a β-adrenergic agonist† [off-label].
Some clinicians consider ipratropium as adjunctive therapy in patients with moderate or severe exacerbations (peak expiratory flow rate ≤80% of predicted) of asthma† [off-label] who fail to respond adequately to β-adrenergic agonists and corticosteroids.
May be useful for prevention or reversal of bronchospasm induced by β-adrenergic blocking agents† [off-label] (e.g., propranolol) in asthmatic patients; β-adrenergic bronchodilators generally ineffective for this indication in such patients.
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How to use Ipratropium (Systemic, Oral Inhalation)
Administration
Administer by oral inhalation using an oral aerosol inhaler or via nebulization.
Oral Inhalation via Metered-dose Aerosol
Ipratropium BromideAerosol delivers ≥200 metered sprays per canister.
Patient should be instructed to clear excessive sputum from chest before inhalation.
Shake well immediately prior to use. Actuate aerosol inhaler 3 times prior to the initial use or if it has not been used for >24 hours.
Do not use mouthpiece for other aerosol drugs.
Exhale slowly and completely and place the mouthpiece of the inhaler well into the mouth with the lips closed around it. To avoid contact of the drug with the eyes and subsequent adverse effects, close eyes during inhalation of aerosol. Inhale slowly and deeply through the mouth while actuating the inhaler. Hold the breath for 10 seconds, withdraw the mouthpiece, and exhale slowly.
Allow ≥15 seconds to elapse between subsequent inhalations from the aerosol inhaler.
Wash the mouthpiece in hot running water as needed. If soap is used, rinse mouthpiece thoroughly with plain water.
Ipratropium Bromide and Albuterol SulfateAerosol delivers ≥200 metered sprays per canister.
Shake well immediately prior to use. Actuate 3 times prior to the initial use or if it has not been used for >24 hours. Do not use actuator provided for other aerosol drugs. To avoid contact of the drug with the eyes and subsequent adverse effects, close eyes during inhalation of aerosol.
Exhale deeply and place mouthpiece of the inhaler into the mouth. Inhale slowly and deeply through the mouth while actuating the inhaler. Hold the breath for 10 seconds, withdraw the mouthpiece, and exhale slowly. Allow approximately 2 minutes to elapse and repeat the procedure. Rinse the mouthpiece in hot water as needed. If soap is used, rinse the mouthpiece thoroughly with plain water. When dry, replace the cap on the mouthpiece when the inhaler is not in use.
Oral Inhalation via Nebulization
Ipratropium BromideEmpty entire contents of the single-use vial of solution into the nebulizer reservoir and attach reservoir to the mouthpiece or face mask and to the compressor according to the manufacturer’s instructions.
Use care when a face mask is used to avoid leakage since transient blurred vision and other adverse effects may result if the drug enters the eyes. (See Ocular Effects under Cautions.) Use of a mouthpiece may avoid inadvertent entry of drug into the eye.
Place the mouthpiece of the nebulizer in the mouth or put on the nebulizer face mask. Breathe as calmly, deeply, and evenly as possible until the nebulizer stops producing mist.
Duration of treatment usually is about 5–15 minutes.
Ipratropium Bromide and Albuterol SulfateEmpty entire contents of the single-use vial of solution into the nebulizer reservoir and attach reservoir to the mouthpiece or face mask and to the compressor according to the manufacturer’s instructions.
Place the mouthpiece of the nebulizer in the mouth or put on the nebulizer face mask. Breathe as calmly, deeply, and evenly as possible until the nebulizer stops producing mist.
Duration of treatment usually is about 5–15 minutes.
Clean the nebulizer after use according to the manufacturer’s instructions.
Dosage
Available as ipratropium bromide.
Dosage of oral inhalation aerosol expressed in terms of the monohydrate.
Dosage of inhalation solution for nebulization expressed in terms of anhydrous drug.
Using in vitro testing at an average flow rate of 3.6 L per minute for an average of ≤15 minutes, the Pari-LC Plus nebulizer delivered at the mouthpiece approximately 46 or 42% of the original dosage of albuterol or ipratropium bromide, respectively.
Pediatric Patients
COPD InhalationPatients ≥12 years of age: 36 mcg (2 inhalations) 4 times daily via a metered-dose aerosol, given alone or in fixed combination with albuterol (90 mcg via the mouthpiece). Additional inhalations should not exceed 216 mcg (12 inhalations) of ipratropium bromide in 24 hours.
Patients ≥12 years of age: 500 mcg (contents of 1 unit-dose vial) 3 or 4 times daily (i.e., every 6–8 hours) via a nebulizer.
Adults
COPD InhalationInitially, 36 mcg (2 inhalations) 4 times daily via a metered-dose aerosol, given alone or in fixed combination with albuterol (90 mcg from the mouthpiece). Additional inhalations should not exceed 216 mcg (12 inhalations) in 24 hours.
Initially, 500 mcg 3 or 4 times daily (i.e., every 6–8 hours) via a nebulizer. With ipratropium bromide in fixed combination with albuterol sulfate (DuoNeb), 500 mcg 4 times daily. Additional inhalations should not exceed 6 inhalations daily.
Prescribing Limits
Pediatric Patients
COPD InhalationMaximum 216 mcg (12 inhalations via a metered-dose inhaler) in 24 hours.
Maximum 12 inhalations via metered-dose inhaler in 24 hours with the fixed combination of ipratropium bromide and albuterol sulfate.
500 mcg 3–4 times daily via a nebulizer in patients ≥12 years of age.
Adults
COPD InhalationMaximum 216 mcg (12 inhalations via a metered-dose inhaler) in 24 hours; frequency of administration should not exceed 4 times daily.
Maximum 12 inhalations via metered-dose inhaler in 24 hours with the fixed combination of ipratropium bromide and albuterol sulfate.
500 mcg 3–4 times daily via a nebulizer.
Special Populations
Geriatric Patients
Dosage adjustments based solely on age are not necessary.
Warnings
Contraindications
Warnings/Precautions
Warnings
Acute BronchospasmDelayed onset of action; not indicated for initial treatment. Generally should not be used alone for the management of acute bronchospasm, when a rapid response is required.
Sensitivity Reactions
Immediate hypersensitivity reactions, including rash, angioedema of the tongue, lips, and face, urticaria, bronchospasm, oropharyngeal edema, and anaphylactic reaction.
Possible paradoxical bronchospasm.
General Precautions
Worsening COPDContact a clinician immediately if a previously effective dosage regimen fails to provide the usual relief (e.g., need to increase the dose or frequency of administration of the drug). Do not increase the dose or frequency of inhalation without consultation with a clinician.
Ocular EffectsPossible temporary blurred vision, mydriasis, ocular pain, conjunctival or corneal congestion associated with visual halos or colored images, or precipitation or worsening of angle-closure glaucoma following inadvertent contact of ipratropium with the eyes.
Minimize ocular exposure by using a mouthpiece rather than a face mask during administration via a nebulizer. During oral inhalation of aerosol, close eyes. Inhalation aerosol should not be administered using the open-mouth technique in these patients with angle-closure glaucoma. Use with caution in patients with angle-closure glaucoma.
Genitourinary EffectsPossible urinary retention/difficulty, urinary tract infection, or dysuria.
Use with caution in patients with bladder neck obstruction or prostatic hypertrophy.
Cardiovascular EffectsPossible adverse cardiovascular effects (e.g., tachycardia, palpitations, aggravated hypotension or hypertension).
Use of Fixed CombinationWhen used in fixed combination with other agents, consider the cautions, precautions, and contraindications associated with the concomitant agents.
Specific Populations
PregnancyCategory B.
LactationUse with caution.
Pediatric UseSafety and efficacy of oral inhalation not established in children <12 years of age.
Hepatic ImpairmentUse with caution.
Renal ImpairmentUse with caution.
Common Adverse Effects
Bronchitis, upper respiratory tract infection, cough, and dryness of the mouth, throat, or tongue with ipratropium aerosol. Adverse effects resulting in discontinuance of nebulized ipratropium most frequently include bronchitis, dyspnea, and bronchospasm.
What other drugs will affect Ipratropium (Systemic, Oral Inhalation)
Limited systemic absorption following oral inhalation; interactions with systemically administered drugs unlikely.
Specific Drugs
Drug
Interaction
Comments
Antimuscarinic agents
Potential pharmacodynamic interaction (additive effects)
Caution advised with concomitant administration
Methylxanthine derivatives
No adverse drug interactions reported
β-Adrenergic agonists
Potential pharmacodynamic interaction (additive effects)
If concomitant therapy is required, consider cautious use of cardioselective β-adrenergic blocking agents
Corticosteroids
No adverse drug interactions reported
Cromolyn sodium
No adverse drug interactions reported
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