Irinotecan

Generic name: Irinotecan
Brand names: Camptosar
Dosage form: intravenous solution (20 mg/mL)
Drug class: Miscellaneous antineoplastics

Usage of Irinotecan

Irinotecan is used to treat cancers of the colon and rectum. It is usually given with other cancer medicines.

Irinotecan may also be used for purposes not listed in this medication guide.

Irinotecan side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Irinotecan may cause serious side effects. Call your doctor at once if you have:

  • severe or ongoing vomiting or diarrhea;
  • black or bloody stools;
  • nausea or vomiting that keeps you from drinking enough fluids;
  • sores or white patches in or around your mouth;
  • new or worsening cough or shortness of breath;
  • dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;
  • low blood cell counts--fever, tiredness, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed; or
  • symptoms of sepsis--confusion, fever or chills, severe drowsiness, fast heartbeats, rapid breathing, feeling very ill.
  • Severe diarrhea may be more likely in older adults.

    Common side effects of irinotecan may include:

  • fever, pain, mouth sores, or other signs of infection;
  • low blood cell counts, abnormal liver function tests;
  • diarrhea, constipation;
  • nausea, vomiting, stomach pain;
  • loss of appetite, weight loss;
  • weakness; or
  • hair loss.
  • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Irinotecan

    You should not use irinotecan if you are allergic to it.

    Tell your doctor if you have ever had:

  • liver or kidney disease;
  • lung disease;
  • an intestinal disorder or obstruction;
  • Gilbert's syndrome;
  • fructose intolerance (irinotecan contains sorbitol);
  • radiation treatment to your abdomen or pelvic area; or
  • if you take a diuretic or "water pill."
  • Irinotecan can harm an unborn baby if the mother or the father is using irinotecan.

  • If you are a woman, you may need to have a negative pregnancy test. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.
  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using irinotecan.
  • Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

    Do not breastfeed while using this medicine, and for at least 7 days after your last dose.

    Relate drugs

    How to use Irinotecan

    Usual Adult Dose for Colorectal Cancer:

    COMBINATION REGIMEN 1: 125 mg/m2 IV over 90 minutes on Days 1, 8,15, and 22 with LV 20 mg/m2 IV bolus on Days 1, 8, 15, and 22 followed by 5-FU 500 mg/m2 IV bolus on Days 1, 8, 15, and 22 every 6 weeksCOMBINATION REGIMEN 2: 180 mg/m2 IV over 90 minutes on Days 1, 15, and 29 with LV 200 mg/m2 IV over 2 hours on Days 1, 2, 15, 16, 29, and 30 followed by 5-FU 400 mg/m2 IV bolus on Days 1, 2, 15, 16, 29, and 30 and 5-FU 600 mg/m2 IV over 22 hours on Days 1, 2, 15, 16, 29, 30 (NOTE: 5-FU IV follows 5-FU bolus) SINGLE AGENT REGIMEN 1: 125 mg/m2 IV over 90 minutes on Days 1, 8, 15, and 22 then 2-week restSINGLE AGENT REGIMEN 2: 350 mg/m2 IV over 90 minutes on Day 1 every 3 weeksComments:-It is recommended that patients receive premedication with antiemetics (e.g., 10 mg dexamethasone given in conjunction with another antiemetic agent, such as a 5-HT 3 blocker [e.g., ondansetron or granisetron]). -Antiemetic agents should be given at least 30 minutes before this drug.-Physicians should consider providing patients with an antiemetic regimen (e.g., prochlorperazine) for subsequent use as needed. -A similar antiemetic regimen should be used with combination therapy. -Prophylactic or therapeutic administration of atropine should be considered in patients experiencing cholinergic symptoms.Uses:-First-line therapy in combination with 5-fluorouracil (5-fu) and leucovorin (LV) for patients with metastatic carcinoma of the colon or rectum -Patients with metastatic carcinoma of the colon or rectum whose disease has recurred or progressed following initial fluorouracil-based therapy

    Warnings

    Irinotecan can cause severe diarrhea, which can be life-threatening. Call your doctor whenever you have diarrhea during your treatment with irinotecan.

    What other drugs will affect Irinotecan

    Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

    Many drugs can affect irinotecan. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

    Popular Keywords

    AI Assitant