Isavuconazonium

Generic name: Isavuconazonium
Brand names: Cresemba
Drug class: Azole antifungals

Usage of Isavuconazonium

Isavuconazonium is used to treat infections caused by certain types of fungus (aspergillosis or mucormycosis).

Isavuconazonium may also be used for purposes not listed in this medication guide.

Isavuconazonium side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Some side effects may occur during the injection. Tell your caregiver right away if you feel dizzy, light-headed, difficult breathing, chilled, or have any numbness, tingling, or changes in your sense of touch.

Isavuconazonium may cause serious side effects. Call your doctor at once if you have:

liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.

Common side effects of isavuconazonium may include:

nausea, vomiting, diarrhea, constipation;

swelling in your arms or legs;

headache, back pain;

cough, shortness of breath;

low potassium; or

abnormal liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Isavuconazonium

You should not use isavuconazonium if you are allergic to it, or if you have:

a genetic heart rhythm disorder called short QT syndrome.

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with isavuconazonium. Your doctor may change your treatment plan if you also use:

Carbamazepine;

ketoconazole;

phenobarbital;

rifampin;

ritonavir (at high doses); or

St. John's wort.

Tell your doctor if you have ever had:

liver disease;

a heart rhythm disorder; or

history of an allergic reaction to antifungal medicine, such as fluconazole, itraconazole, ketoconazole, posaconazole, or voriconazole.

Isavuconazonium may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 28 days after your last dose. Tell your doctor if you become pregnant.

You should not breastfeed while using isavuconazonium.

Isavuconazonium is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Isavuconazonium

Usual Adult Dose for Aspergillosis -- Invasive:

Loading Dose: 372 mg IV or orally every 8 hours for 6 doses (48 hours)Maintenance Dose: 372 mg IV or orally once a dayComments:-Isavuconazonium sulfate is the prodrug of isavuconazole; 372 mg of isavuconazonium sulfate is equivalent to 200 mg of isavuconazole.-Maintenance doses should be started 12 to 24 hours after the last loading dose.Uses: For the treatment of invasive aspergillosis and invasive mucormycosis

Usual Adult Dose for Mucormycosis -- Invasive:

Warnings

You should not use isavuconazonium if you have a genetic heart rhythm disorder called short QT syndrome."

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

What other drugs will affect Isavuconazonium

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current medicines. Many drugs can affect isavuconazonium, especially:

digoxin; or

medicine to prevent organ transplant rejection (cyclosporine, sirolimus, tacrolimus).

This list is not complete and many other drugs may affect isavuconazonium. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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