Istodax
Generic name: Romidepsin
Drug class:
Histone deacetylase inhibitors
Usage of Istodax
Istodax blocks certain enzymes in the body and interferes with the growth of tumor cells.
Istodax is a prescription medicine used to treat cutaneous T-cell lymphoma (CTCL) affecting the skin.. It is usually given after at least one other cancer treatment did not work or has stopped working.
It is not known if Istodax is safe and effective in children under 18 years of age.
Istodax side effects
Get emergency medical help if you have signs of an allergic reaction to Istodax: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
You may get infections more easily, even serious or fatal infections, during and after treatment. Call your doctor right away if you have signs of infection such as:
Also call your doctor at once if you have:
Common Istodax side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Istodax
To make sure Istodax is safe for you, tell your doctor if you have ever had:
You may need to have a negative pregnancy test 7 days before starting this treatment.
Both men and women using Istodax should use effective birth control to prevent pregnancy. Men should use condoms. Romidepsin can harm an unborn baby if the mother or father is using this medicine.
Keep using birth control for at least 1 month after your last dose. Tell your doctor right away if a pregnancy occurs.
Istodax can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. Use barrier birth control to prevent pregnancy: condom, diaphragm, cervical cap, or contraceptive sponge.
Pregnancy may be less likely to occur while the mother or the father is using Istodas. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.
You should not breastfeed while using Istodax, and for at least 1 week after your last dose.
Relate drugs
How to use Istodax
Usual Adult Dose of Istodax for Cutaneous T-cell Lymphoma:
14 mg/m2 IV over 4 hours on days 1, 8, and 15 of a 28-day cycle; repeat cycle every 28 days provided patient continues to benefit and is tolerating therapy Uses: For the treatment of cutaneous T-cell Lymphoma (CTCL) and peripheral T-cell lymphoma (PTCL) in patients who have received at least 1 prior systemic therapy.
Usual Adult Dose of Istodax for Peripheral T-cell Lymphoma:
14 mg/m2 IV over 4 hours on days 1, 8, and 15 of a 28-day cycle; repeat cycle every 28 days provided patient continues to benefit and is tolerating therapy Uses: For the treatment of cutaneous T-cell Lymphoma (CTCL) and peripheral T-cell lymphoma (PTCL) in patients who have received at least 1 prior systemic therapy.
Warnings
Before you receive Istodax, tell your doctor if you have an electrolyte imbalance, a personal or family history of "Long QT syndrome," heart disease, kidney disease, or liver disease.
Do not receive Istodax if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. Hormonal forms of contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking Istodax.
What other drugs will affect Istodax
Istodax can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.
Tell your doctor about all your current medicines. Many drugs can interact with romidepsin, especially:
This list is not complete and many other drugs may interact with romidepsin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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