Ivosidenib
Generic name: Ivosidenib
Brand names: Tibsovo
Dosage form: oral tablet (250 mg)
Drug class:
Miscellaneous antineoplastics
Usage of Ivosidenib
Ivosidenib targets a specific gene mutation called IDH1, which can affect your bone marrow. IDH1 mutation prevents young blood cells from developing into healthy adult blood cells, which can result in symptoms of acute myeloid leukemia (AML).
Ivosidenib is for use only in adults with an IDH1 mutation. Your doctor will test you for this gene.
Ivosidenib is used to treat AML after other treatments did not work or stopped working.
Ivosidenib is also used to treat AML in adults 75 years and older who have newly-diagnosed AML and cannot use certain chemotherapy treatments because of other health problems.
Ivosidenib is also used to treat bile duct cancer that has progressed or has spread to other parts of the body (metastatic) after treatment with other medicine.
Ivosidenib may also be used for purposes not listed in this medication guide.
Ivosidenib side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Ivosidenib can cause a condition called differentiation syndrome, which affects blood cells and can be fatal if not treated. This condition may occur within 1 days to 3 months after you start taking ivosidenib.
Seek medical help right away if you have symptoms of differentiation syndrome:
Ivosidenib may cause serious side effects. Call your doctor at once if you have:
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects of ivosidenib may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Ivosidenib
You should not use ivosidenib if you are allergic to it.
Tell your doctor if you have ever had:
May harm an unborn baby. Use birth control and tell your doctor if you become pregnant.
Ivosidenib can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. Use barrier birth control to prevent pregnancy: condom, diaphragm, cervical cap, or contraceptive sponge.
Pregnancy may be less likely to occur while the mother or the father is using ivosidenib. Women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.
Do not breastfeed while using ivosidenib, and for at least 1 month after your last dose.
Relate drugs
- Abiraterone
- Abiraterone, micronized
- Adagrasib
- Adstiladrin
- Altretamine
- Amivantamab
- Amivantamab-vmjw
- Arsenic trioxide
- Asparaginase Erwinia chrysanthemi
- Asparaginase erwinia chrysanthemi recombinant-rywn
- Asparlas
- Axicabtagene ciloleucel
- Azacitidine
- Azacitidine (Injection)
- Azacitidine (Oral)
- Abecma
- Bacillus of calmette and guerin vaccine, live (Intradermal)
- Bacillus of calmette and guerin vaccine, live (Intravesical)
- BCG intravesical
- Belantamab mafodotin
- Belantamab mafodotin-blmf
- Belzutifan
- Besponsa
- Bexarotene
- Bexarotene (Oral)
- Blenrep
- Brexucabtagene autoleucel
- Breyanzi
- Calaspargase pegol
- Calaspargase pegol-mknl
- Camptosar
- Carvykti
- Ciltacabtagene autoleucel
- Danyelza
- Dinutuximab
- Elahere
- Elotuzumab
- Elzonris
- Empliciti
- Enasidenib
- Enfortumab vedotin
- Enfortumab vedotin-ejfv
- Erwinaze
- Hexalen
- Hycamtin (Topotecan Intravenous)
- Hycamtin (Topotecan Oral)
- Hycamtin oral/injection
- Idecabtagene vicleucel
- Idhifa
- Imlygic
- Inotuzumab ozogamicin
- Irinotecan
- Irinotecan liposomal
- Irinotecan liposome
- Ivosidenib
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- Krazati
- Kymriah
- Lartruvo
- Levamisole
- Lisocabtagene maraleucel
- Loncastuximab tesirine
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- Lumakras
- Lumoxiti
- Lunsumio
- Lysodren
- Matulane
- Mirvetuximab soravtansine
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- Mitotane
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- Nadofaragene firadenovec-vncg
- Naxitamab
- Naxitamab-gqgk
- Novaplus Irinotecan Hydrochloride
- Olaratumab
- Olutasidenib
- Omacetaxine
- Oncaspar
- Onivyde
- Onureg
- Padcev
- Pegaspargase
- Polatuzumab vedotin
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- Polivy
- Poteligeo
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- Synribo
- Tagraxofusp
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- Talimogene laherparepvec
- Talquetamab
- Talquetamab-tgvs
- Talvey
- Targretin
- Targretin (Bexarotene Oral)
- Tazemetostat
- Tazverik
- Tebentafusp
- Tebentafusp-tebn
- Tecartus
- Teclistamab
- Teclistamab-cqyv
- Tecvayli
- Theracys
- Tibsovo
- Tice BCG
- Tice BCG Live (for intravesical use)
- Tisagenlecleucel
- Tisotumab vedotin
- Tisotumab vedotin-tftv
- Tivdak
- Topotecan (Intravenous)
- Topotecan (Oral)
- Topotecan oral/injection
- Tretinoin
- Tretinoin (Oral)
- Trisenox
- Trodelvy
- Unituxin
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- Verteporfin
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- Visudyne
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- Yonsa (Abiraterone, micronized Oral)
- Zynlonta
- Zytiga
How to use Ivosidenib
Usual Adult Dose for Acute Myeloid Leukemia:
500 mg orally once a dayDuration of therapy: Until disease progression or unacceptable toxicityComments:-For patients without disease progression or unacceptable toxicity, therapy should continue for at least 6 months to allow time for clinical response.-Combination regimen: Administration of this drug should start on Cycle 1 Day 1 in combination with azacitidine; the manufacturer product information for azacitidine should be consulted.Uses:-In combination with azacitidine or as monotherapy, for the treatment of newly diagnosed acute myeloid leukemia (AML) with a susceptible isocitrate dehydrogenase-1 (IDH1) mutation as detected by a US FDA-approved test in patients 75 years and older or who have comorbidities that preclude use of intensive induction chemotherapy-For the treatment of patients with relapsed or refractory AML with a susceptible IDH1 mutation as detected by a US FDA-approved test
Usual Adult Dose for Cholangiocarcinoma of biliary tract:
500 mg orally once a dayDuration of therapy: Until disease progression or unacceptable toxicityUse: For the treatment of patients with previously treated, locally advanced or metastatic cholangiocarcinoma with an IDH1 mutation as detected by a US FDA-approved test
Warnings
Ivosidenib can cause a condition called differentiation syndrome, which affects blood cells and can be fatal if not treated. This condition may occur within 1 days to 3 months after you start taking ivosidenib.
Seek medical help right away if you have symptoms of differentiation syndrome: fever, dizziness, cough, trouble breathing, swelling, rapid weight gain, rash, or decreased urination.
What other drugs will affect Ivosidenib
Ivosidenib can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.
Other drugs may affect ivosidenib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.
Disclaimer
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The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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