Ixabepilone

Generic name: Ixabepilone
Brand names: Ixempra
Dosage form: intravenous powder for injection (15 mg; 45 mg)
Drug class: Mitotic inhibitors

Usage of Ixabepilone

Ixabepilone is used to treat advanced breast cancer.

Ixabepilone is usually given after other treatments have failed.

Ixabepilone may also be used for purposes not listed in this medication guide.

Ixabepilone side effects

Get emergency medical help if you have signs of an allergic reaction: itching, hives, rash; feeling dizzy or faint; warmth or tingly feeling; difficulty breathing, chest tightness; pounding heartbeats or fluttering in your chest; swelling of your face, lips, tongue, or throat.

Ixabepilone may cause serious side effects. Call your doctor at once if you have:

numbness, tingling, burning pain, discomfort, or loss of feeling anywhere in your body;

pain or burning when you urinate;

unusual weight gain;

pain, blisters, bleeding, or severe rash on the palms of your hands or the soles of your feet;

chest pain, difficult breathing;

pounding heartbeats or fluttering in your chest;

low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; or

signs of a blood clot--sudden numbness or weakness, problems with vision or speech, swelling or redness in an arm or leg.

Common side effects of ixabepilone may include:

blisters or severe rash on the palms of your hands or the soles of your feet;

headache;

tiredness;

joint or muscle pain;

lip, mouth, and esophagus sores;

hair loss;

fever;

anemia, decreased platelets;

nausea, vomiting, stomach pain, loss of appetite;

diarrhea, constipation; or

problems with your fingernails or toenails.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Ixabepilone

You should not be treated with ixabepilone if you are allergic to Cremophor (synthetic castor oil).

You may not be able to receive ixabepilone if you have:

liver problems and are also taking Capecitabine; or

low platelets or white blood cell counts.

Tell your doctor if you have ever had:

liver disease;

heart disease;

nerve problems (especially in your hands or feet);

diabetes; or

bone marrow suppression or a weak immune system.

Ixabepilone may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.

You should not breastfeed while using ixabepilone.

Relate drugs

How to use Ixabepilone

Usual Adult Dose for Breast Cancer:

Recommended dosage: 40 mg/m2 IV over 3 hours every 3 weeksThe dosage for patients with a body surface area (BSA) exceeding 2.2 m2 should be calculated based on a 2.2 m2 BSA.Comments:- All patients should be premedicated approximately 1 hour before the infusion (see Administration Advice).Uses: -In combination with capecitabine for the treatment of patients with metastatic or locally advanced breast cancer resistant to treatment with an anthracycline and a taxane, or whose cancer is taxane resistant and for whom further anthracycline therapy is contraindicated. ---Anthracycline resistance is defined as progression while on therapy or within 6 months in the adjuvant setting or 3 months in the metastatic setting. ---Taxane resistance is defined as progression while on therapy or within 12 months in the adjuvant setting or 4 months in the metastatic setting. -As monotherapy for the treatment of metastatic or locally advanced breast cancer in patients whose tumors are resistant or refractory to anthracyclines, taxanes, and capecitabine.

Warnings

You should not use ixabepilone along with capecitabine if you have liver problems.

Ixabepilone can increase your risk of bleeding or infection. Call your doctor if you have unusual bruising or bleeding, or new signs of infection (fever, chills, easy bruising, unusual bleeding, burning when you urinate).

What other drugs will affect Ixabepilone

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can affect ixabepilone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

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