Jackass Bitters

Generic name: Neurolaena Lobata (L.) R. Br.
Brand names: Capitana, Contragavilana, Cow-gall Bitter, Gavilana, Herbe-a-pique, Inaciabi, Jackass Bitters, Mano De Lagarto, Tres Puntas, Zeb-a-pique

Usage of Jackass Bitters

Clinical studies are lacking.

Anti-inflammatory effects

Animal data

Studies in rodents (induced paw edema) and in vitro suggest chemical constituents of N. lobata may have anti-inflammatory activity.(Gracioso 1998, Lajter 2014, McKinnon 2014)

Clinical data

Research reveals no clinical studies regarding the use of N. lobata for anti-inflammatory effect.

Antimicrobial activity

Animal data

Based on in vitro studies, some animal experiments have been conducted.(Berger 1998, Caceres 1998, Franssen 1997, Fujimaki 2005) in vitro antibacterial activity has been reported.(Lentz 1998) Antiplasmodial effects of chemical constituents neurolenins, and of ethanol and methanol extracts have been demonstrated in rodents.(Berger 2001, Francois 1996)

Other uses

Hypoglycemic activity in mice was demonstrated in an older study.(Gupta 1984) More animal and in vitro studies have cOnfirmed hypoglycemic activity of N. lobata extract in a rat diabetic model with a mechanism of action that did not include the mammalian alpha-glucosidase enzyme.(Andrade-Cetto 2019)

Various fractions of a hydroalcoholic extract of N. lobata aerial parts reduced gastric lesion formation in rodent models. Researchers suggest the mechanism of action may be associated with mucus production and prostaglandin synthesis.(Gracioso 2000) Wound healing in a study in rats was improved with extracts of the leaves of the plant.(Nayak 2014)

Extracts of the branches, leaves, and stems of N. lobata HAD moderate Neutralization activity at doses up to 4 mg per mouse against the hemorrhagic effect of Bothrops atrox snake venom of from Antioquia and Chocó, northwestern Colombia.(Otero 2000)

Jackass Bitters side effects

None well documented.

Before taking Jackass Bitters

Avoid use during pregnancy and lactation because of lack of clinical studies.Francois 1996

How to use Jackass Bitters

None has been validated by clinical data. Ethnomedicinal resources vary for doSage of an N. lobata leaf decoction in treating malaria, ranging from 3 glasses daily for 4 days to 1 glass daily before breakfast for 7 days.Berger 1998, Giron 1991

Warnings

Chemical analysis revealed the presence of pyrrolizidine alkaloids; however, toxic necine pyrrolizidines were not present. No toxicity was observed with oral doses up to 5,000 mg/kg in mice. Gracioso 1998, Gracioso 1996

What other drugs will affect Jackass Bitters

None validated by clinical data. The herb has the potential to produce additive effects in patients also taking analgesics, diuretics, or antimalarial medications.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords