Jesduvroq
Generic name: Daprodustat
Dosage form: Tablet
Drug class:
Miscellaneous uncategorized agents
Usage of Jesduvroq
Jesduvroq (Daprodustat) tablets are used to treat anemia (low red blood cells) that is caused by chronic kidney disease (CKD) in patients who have been on dialysis. Jesduvroq is used to reduce or avoid the need to have red blood cell (RBC) transfusions.
Jesduvroq works by increasing the hormone erythropoietin which tells the body to make more red blood cells. Jesduvroq is a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI).
Jesduvroq tablets are taken orally once daily. Jesduvroq is the first oral treatment that is FDA approved to treat anemia that is caused by CKD, other FDA-approved treatments for this condition need to be injected into the blood or under the skin.
Clinical studies of Jesduvroq has not been proven to improve quality of life, tiredness (fatigue), or well-being. Jesduvroq should not be used:
Jesduvroq side effects
Serious side effects of Jesduvroq include:
Most common side effects of Jesduvroq include:
These are not all the possible side effects of this medicine. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800- FDA-1088.
Before taking Jesduvroq
Do not take Jesduvroq if you:
Jesduvroq is not recommended in severe liver impairment.
Jesduvroq is not approved to be used in children.
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How to use Jesduvroq
Take this medicine exactly as your healthcare provider tells you to take it.
Your healthcare provider will do certain blood tests before you start Jesduvroq and during treatment as needed. Based on the results of your blood tests your healthcare provider may change your dose of this medicine.
What happens if I miss a dose?
If you miss a dose of this medicine, take it as soon as you remember, unless it the same day as your next dose. If it is the same day as your next dose, skip the missed dose and take your next dose at your usual time.
Do not take 2 doses at the same time to make up for the missed dose.
What happens if I overdose?
If you take more than your prescribed dose of Jesduvroq, you should contact your healthcare provider, or go to the nearest hospital emergency room right away.
Warnings
Jesduvroq may cause serious side effects, including:
Increased risk of death, heart attack, stroke, and blood clots. These risks may happen if you are treated with Jesduvroq to increase red blood cells (RBCs) to near the same level found in healthy people. These risks may be increased if you have heart or blood vessel problems or problems with blood flow to your brain (cerebrovascular disease). Blood clots can form in the blood vessels (veins), including in your legs (deep vein thrombosis or DVT), lungs (pulmonary embolism or PE), and in your dialysis access (vascular access thrombosis or VAT). Get medical help right away if you get any of the following symptoms:
See “What are the side effects of Jesduvroq?” for more information about side effects.
If you decide to take Jesduvroq, your healthcare provider should prescribe the lowest dose of Jesduvroq that is necessary to reduce your chance of needing red blood cell transfusions.
What other drugs will affect Jesduvroq
Tell your healthcare provider about all medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Taking Jesduvroq with certain other medicines may affect how Jesduvroq or the other medicines work and can cause side effects. Jesduvroq interacts with other drugs that are metabolized in a certain way. Tell your doctor if you are taking medicines that contain any of the following drugs:
CYP2C8 Inhibitors: gemfibrozil (Lopid), clopidogrel (Plavix)
CYP2C8 Inducers: rifampin (Rifadin)
This list is not complete. Many other drugs may interact with Jesduvroq, not all possible interactions are listed in this medicine guide.
Disclaimer
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The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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