Jevtana

Generic name: Cabazitaxel
Drug class: Mitotic inhibitors

Usage of Jevtana

Jevtana is a prescription cancer medicine that interferes with the growth and spread of cancer cells in the body.

Jevtana is used together with prednisone to treat prostate cancer that is resistant to medical or surgical treatments that lower Testosterone and has spread to other parts of the body (metastatic).

Jevtana is usually given when the prostate cancer has worsened (progressed) after being previously treated with other medicines that included docetaxel as part of the treatment.

Jevtana side effects

Jevtana can cause a serious allergic Reaction. Get emergency medical help if you have signs of an allergic reaction to Jevtana: hives, rash or skin redness; chest tightness or trouble breathing; feeling light-headed; swelling of your face, lips, tongue, or throat.

Jevtana can cause serious or fatal side effects. Call your doctor at once if you have:

numbness, burning pain, or tingly feeling in your hands or feet;

sudden chest pain or discomfort, wheezing, dry cough, feeling short of breath;

stomach pain or tenderness, severe vomiting or diarrhea, ongoing constipation;

blood in your urine, urinating more often, pain or burning when you urinate;

low blood cell counts - fever, chills, muscle pain, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath;

signs of stomach bleeding - bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or

signs of a kidney problem - little or no urinating; painful or difficult urination; swelling in your hands or feet; feeling tired or short of breath.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Some side effects may be more likely in older adults.

Common Jevtana side effects may include:

fever, low blood cell counts;

numbness or tingling;

nausea, vomiting, stomach pain, loss of appetite;

constipation, diarrhea;

weakness, tired feeling;

blood in your urine;

back pain, joint pain;

cough, shortness of breath;

altered sense of taste; or

hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Jevtana

You should not use Jevtana if you are allergic to Cabazitaxel, or if you have:

severe liver disease;

low white blood cell counts; or

an allergy to any medicine that contains polysorbate 80.

To make sure Jevtana is safe for you, tell your doctor if you have ever had:

radiation treatment;

liver or kidney disease;

breathing problems; or

a severe allergic reaction to any medication.

Although not for use by women, cabazitaxel can cause birth defects in a baby if the father is using this medicine.

Use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Tell your doctor at once if a pregnancy occurs during this time.

This medicine may affect fertility (your ability to have children). However, it is important to use birth control to prevent pregnancy because cabazitaxel can harm an unborn baby.

Relate drugs

How to use Jevtana

Usual Adult Dose for Prostate Cancer:

25 mg/m2 IV over 1 hour every three weeks Comments: -Use in combination with prednisone or prednisolone. -Give premedication regimen at least 30 minutes prior to each administration. -Give antiemetics prophylactically or as needed. -Ensure adequate hydration throughout treatment. Use: Use in combination with prednisone or prednisolone for the treatment of patients with hormone refractory metastatic prostate cancer previously treated with a docetaxel containing regimen.

Warnings

You should not use Jevtana if you have severe liver disease, low white blood cell counts, or an allergy to any medicine that contains polysorbate 80.

Jevtana affects your immune system. You may get infections more easily, even serious or fatal infections, especially if you are 65 or older. Call your doctor if you have a fever, muscle pain, cough, diarrhea, or pain or burning when you urinate.

Call your doctor right away if you have symptoms such as: fever, cough, body aches, easy bruising or bleeding, burning when you urinate, decreased urination, swelling in your hands or feet, severe stomach pain, constipation, blood in your urine or stools, or sudden chest pain and shortness of breath.

A serious allergic reaction may occur during the injection. Tell your caregivers right away if you have a rash or skin redness, chest tightness or trouble breathing, or if you feel like you might pass out.

What other drugs will affect Jevtana

Sometimes it is not safe to use certain medications at the SAMe time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may interact with cabazitaxel, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.