Joenja

Generic name: Leniolisib
Dosage form: tablets
Drug class: PI3K inhibitors

Usage of Joenja

Joenja is a prescription medicine used to treat a rare, genetic disease that affects the immune system called activated phosphoinositide 3-kinase delta syndrome (APDS).

APDS is a type of primary immunodeficiency disorder that causes increased susceptibility to infections.

Joenja contains Leniolisib which belongs to a new class of drugs called phosphoinositide 3-kinase delta (PI3Kẟ) inhibitors. Leniolisib works by inhibiting a certain cellular messenger that interferes with the normal development and function of immune cells in the body. 

Joenja side effects

Common side effects include:

  • headache
  • inflammation of sinuses
  • eczema (dry, itchy, and inflamed skin).
  • These are not all the possible side effects. Tell your healthcare provider about any side effect that bothers you or does not go away.

    Before taking Joenja

    Before you start treatment, tell your healthcare provider about all of your medical conditions.

    Pregnancy

    Tell your healthcare provider if you are pregnant or plan to become pregnant. Joenja may harm your unborn baby. Your healthcare provider will do a pregnancy test before you start treatment.

    Use effective birth control to prevent pregnancy during treatment, and for one week after you stop treatment. If you plan to become pregnant, continue taking your birth control for one week after you stop treatment. Talk to your doctor about what type of birth control method is right for you.

    Breastfeeding

    It is not known if this medicine passes into your breast milk. Breastfeeding is not advised during treatment, and for one week after the last dose.

    Talk to your doctor about the best way to feed your baby during treatment.

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    How to use Joenja

    Usual Adult Dose for Activated Phosphoinositide 3-Kinase Delta Syndrome (APDS):

    70 mg orally twice daily

    Comments: - verify pregnancy status in females of reproductive potential prior to initiating treatment.

    Use: - treatment of activated phosphoinositide 3-kinase delta (PI3Kδ) syndrome (APDS) in adult and pediatric patients 12 years of age and older and weighing ≥45kg

    Warnings

    Joenja can cause harm to an unborn baby. Tell your healthcare provider if you are pregnant or plan to become pregnant.

    You will need to use effective birth control during treatment, and for one week after the last dose.

    What other drugs will affect Joenja

    Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Joenja and certain other medicines may affect each other.

    Tell your healthcare provider if you are scheduled to receive an immunization (vaccine). Joenja may affect how well a vaccine works.

    Know the medicines you take. Keep a list of your medicines and show it to your healthcare provider and pharmacist when you get a new medicine.

    Disclaimer

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