Juluca

Generic name: Dolutegravir And Rilpivirine
Drug class: Antiviral combinations

Usage of Juluca

Juluca contains a combination of dolutegravir and rilpivirine. Dolutegravir and rilpivirine are antiviral medicines that prevents human immunodeficiency virus (HIV) from multiplying in your body.

Juluca is used to treat HIV, the virus that can cause the acquired immunodeficiency syndrome (AIDS).

Juluca is not a cure for HIV or AIDS.

Juluca is for use only in people who have been successfully treated with other antiviral medications for at least 6 months.

Juluca side effects

Stop taking this medicine and get emergency medical help if you have signs of an allergic Reaction to Juluca: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Call your doctor at once if you have:

thoughts about suicide or hurting yourself;

anxiety, sadness, feeling hopeless;

depression - mood changes, feelings of low self-worth, loss of interest in things you once enjoyed, new sleep problems, thoughts about hurting yourself; or

liver problems - nausea, vomiting, loss of appetite, right-sided upper stomach pain, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Dolutegravir and rilpivirine affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have:

signs of a new infection - fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;

trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or

swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.

Common Juluca side effects may include:

headache; or

nausea, diarrhea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Juluca

You should not use Juluca if you are allergic to dolutegravir or rilpivirine.

Some medicines can cause unwanted or dangerous effects when used with Juluca. Your doctor may need to change your treatment plan if you also use:

dofetilide (can cause serious medical problems or death when taken with Juluca);

St John's wort;

more than one dose of Dexamethasone;

Carbamazepine, oxcarbazepine, phenobarbital, phenytoin;

rifampin, rifapentine; or

esOmeprazole, Lansoprazole, omeprazole, Pantoprazole, rabeprazole.

To make sure Juluca is safe for you, tell your doctor if you have ever had:

liver problems;

mental illness;

a severe skin rash or allergic reaction to dolutegravir or rilpivirine; or

if you also take rifabutin.

You may need to have a negative pregnancy test before starting this treatment.

Juluca may harm an unborn baby if you take the medicine at the time of conception or during the first 12 weeks of pregnancy. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.

HIV can be passed to your baby if the virus is not controlled during pregnancy. If you are pregnant, your name may be listed on a registry to track any effects of antiviral medicine on the baby. Use your medications properly to control HIV.

Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

Relate drugs

How to use Juluca

Usual Adult Dose of Juluca for HIV Infection:

1 tablet orally once a day with a meal Use: As a complete regimen for the treatment of HIV-1 infection to replace a stable antiretroviral regimen in patients who are virologically-suppressed (HIV-1 RNA less than 50 copies/mL) for at least 6 months with no history of treatment failure and no known substitutions associated with resistance to the individual components

Warnings

Taking Juluca during the first trimester of pregnancy may cause birth defects. Use effective birth control to prevent pregnancy while you are using dolutegravir.

What other drugs will affect Juluca

Some medicines can make Juluca less effective when taken at the SAMe time. If you take any of the following medicines, take your dose at least 4 hours before or 6 hours after you take the other medicine.

antacids or laxatives that contain calcium, magnesium, or aluminum (such as Maalox, Milk of Magnesia, Mylanta, Rolaids, Tums, and others), or the ulcer medicine sucralfate (Carafate);

buffered medicine; or

vitamin or mineral supplements that contain calcium or iron (but if you take dolutegravir and rilpivirine with food, you can take these supplements at the same time).

Take your Juluca dose at least 4 hours before or 12 hours after you take famotidine, cimetidine, nizatidine, or ranitidine.

Many drugs can interact with dolutegravir and rilpivirine, and some drugs should not be used together. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.