Kadcyla
Generic name: Ado-trastuzumab Emtansine
Drug class:
HER2 inhibitors
Usage of Kadcyla
Kadcyla is a cancer medicine that interferes with the growth and spread of cancer cells in the body.
Kadcyla is used to treat HER2-positive breast cancer.
Kadcyla is used both for early breast cancer and for breast cancer that has spread to other parts of the body (metastatic).
Kadcyla is usually given after other cancer medications have been tried without success.
Kadcyla should not be used in place of Herceptin (trastuzumab).
Kadcyla side effects
Get emergency medical help if you have signs of an allergic Reaction to Kadcyla: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects may occur during the injection. Tell your caregiver right away if you feel cold, light-headed, feverish or sweaty, or have chest tightness, rapid heartbeats, or trouble breathing.
Call your doctor at once if you have:
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common Kadcyla side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Kadcyla
You should not use Kadcyla if you are allergic to ado-trastuzumab emtansine.
Do not use Kadcyla if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 7 months after your last dose.
Tell your doctor if you become pregnant during treatment.
To make sure Kadcyla is safe for you, tell your doctor if you have ever HAD:
You should not breast-feed while using this medicine.
Relate drugs
- Ado-trastuzumab emtansine
- Enhertu
- Fam-trastuzumab deruxtecan
- Fam-trastuzumab deruxtecan-nxki
- Herceptin
- Herceptin Hylecta
- Herzuma
- Herzuma (Trastuzumab Intravenous)
- Herzuma (Trastuzumab-pkrb Intravenous)
- Hyaluronidase and trastuzumab
- Hyaluronidase, pertuzumab, and trastuzumab
- Kadcyla
- Margenza
- Margetuximab
- Margetuximab-cmkb
- Ogivri
- Ogivri (Trastuzumab Intravenous)
- Ogivri (Trastuzumab-dkst Intravenous)
- Ontruzant
- Ontruzant (Trastuzumab Intravenous)
- Ontruzant (Trastuzumab-dttb Intravenous)
- Perjeta
- Pertuzumab
- Pertuzumab, trastuzumab, and hyaluronidase-zzxf
- Phesgo
- Trastuzumab
- Trastuzumab and hyaluronidase-oysk
- Trastuzumab-anns
- Trastuzumab-dkst
- Trastuzumab-dttb
- Trastuzumab-pkrb
- Trazimera
- Tucatinib
- Tukysa
How to use Kadcyla
Usual Adult Dose for Breast Cancer:
3.6 mg/kg IV every 3 weeks (21-Day cycle) until disease progression or uNACceptable toxicity Maximum dose: 3.6 mg/kg IV every 3 weeks Comments: -Administer the first infusion over 90 minutes. Subsequent infusions may be administered over 30 minutes as tolerated. -Observe patients during and for at least 90 minutes following the initial dose for fever, chills, or other infusion-related reactions. -Patients should have a HER2 positive tumor status cOnfirmed prior to starting therapy. -Do not substitute trastuzumab emtansine for or with trastuzumab. -If a planned dose is delayed or missed, it should be administered as soon as possible; do not wait until the next planned cycle. Use: As a single agent, for HER2-positive, metastatic breast cancer in patients who previously received trastuzumab and a taxane, separately or in combination; patients should have either: -Received prior therapy for metastatic disease OR -Developed disease recurrence during or within 6 months of completing adjuvant therapy
Warnings
Do not use Kadcyla if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.
You may need to have a negative pregnancy test before starting this treatment.
Kadcyla can harm your liver. Call your doctor at once if you have upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).
Before you receive each Kadcyla injection, your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).
What other drugs will affect Kadcyla
Sometimes it is not safe to use certain medications at the SAMe time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Other drugs may interact with ado-trastuzumab emtansine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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