Khapzory

Generic name: Levoleucovorin
Drug class: Antidotes

Usage of Khapzory

Khapzory is used to treat or prevent toxic effects of methotrexate in people who have received methotrexate to treat bone cancer.

Khapzory is also used to treat or prevent toxic effects of methotrexate in people whose bodies do not eliminate methotrexate properly after the drug is metabolized. This medicine may also be used to treat toxic effects of an overdose or methotrexate or certain other medications.

Khapzory is also used in combination chemotherapy with fluorouracil to treat colorectal cancer that has spread to other parts of the body.

Khapzory should not be used to treat anemia that is caused by a lack of vitamin B12.

Khapzory may also be used for purposes not listed in this medication guide.

Khapzory side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your doctor or caregivers at once if you have:

blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;

severe or ongoing diarrhea;

a light-headed feeling, like you might pass out;

seizure (convulsions);

dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin; or

kidney problems--little or no urination; painful or difficult urination; swelling in your feet or ankles.

Common side effects of Khapzory may include:

diarrhea, nausea, vomiting; or

pain or sores in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Khapzory

You should not be treated with Khapzory if you are allergic to Khapzory, folic acid, or folinic acid.

If possible, before you receive Khapzory, tell your doctor or caregivers if you have:

kidney disease; or

if you are dehydrated.

Tell your doctor if you are pregnant or breastfeeding.

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How to use Khapzory

Khapzory is given as an infusion into a vein. A healthcare provider will give you this injection.

For use with methotrexate, Khapzory is usually given every 3 to 6 hours.

For colorectal cancer, Khapzory is usually given daily as a 5-day treatment, repeated every 4 to 5 weeks.

After treatment with Khapzory, you will be watched to make sure this medicine has been effective.

You will need frequent medical tests to help your doctor determine how long to treat you with Khapzory.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What other drugs will affect Khapzory

Tell your doctor about all your other medicines, especially:

seizure medicine--phenobarbital, phenytoin, primidone;

a multivitamin or mineral supplement than contains folic acid; or

a sulfa drug (Bactrim, Septra, Sulfatrim, SMX-TMP or SMZ-TMP, and others).

This list is not complete. Other drugs may affect Khapzory, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.