Kimmtrak

Generic name: Tebentafusp-tebn
Dosage form: injection
Drug class: Miscellaneous antineoplastics

Usage of Kimmtrak

Kimmtrak is a prescription medicine used to treat HLA-A*02:01-positive adults with uveal melanoma that cannot be removed by surgery or has spread.

Your healthcare provider will test you for a presence of HLA-A*02:01 gene to make sure Kimmtrak is right for you. It is not known if this medicine is safe and effective in children.

Kimmtrak side effects

Kimmtrak can cause serious side effects, including:

  • See Important information.
  • Skin reactions. Kimmtrak may cause skin reactions that require treatment. Tell your healthcare provider if you get symptoms of skin reactions, such as rash, itching, or skin swelling, that are severe and do not go away.
  • Abnormal liver blood tests. Your healthcare provider will do blood tests to check your liver before you start Kimmtrak and during treatment. Tell your healthcare provider if you get symptoms of liver problems such as right-sided abdominal pain or yellowing of the skin or eyes.

    • The most common side effects include:

  • cytokine release syndrome (CRS)
  • rash
  • fever
  • itching
  • tiredness
  • nausea
  • chills
  • stomach pain
  • swelling
  • low blood pressure (symptoms may include dizziness or light headedness)
  • dry skin
  • headache
  • vomiting
  • abnormal liver blood tests

    • These are not all the possible side effects. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA1088.

    Before taking Kimmtrak

    Before you receive Kimmtrak, tell your healthcare provider about all of your medical conditions, including if you:

  • are pregnant or plan to become pregnant. Kimmtrak may harm your unborn baby. Tell your healthcare provider if you become pregnant during treatment.

    • For females who are able to become pregnant:

  • Your healthcare provider should do a pregnancy test before you start treatment.
  • Use an effective form of birth control during treatment, and for at least 1 week after the last dose.
  • are breastfeeding or plan to breastfeed. It is not known if Kimmtrak passes into your breast milk. Do not breastfeed during the treatment, and for at least 1 week after the last dose.

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    How to use Kimmtrak

    Usual Adult Dose for Uveal Melanoma

    - 20 mcg intravenously on Day 1, 30 mcg intravenously on Day 8, 68 mcg intravenously on Day 15, and 68 mcg intravenously once every week thereafter. 

    - Use: treatment of HLA-A*02:01-positive adult patients with unresectable or metastatic uveal melanoma.

    Warnings

    Kimmtrak can cause serious side effects that can be severe or, life threatening, and usually happens within the first three infusions. These side effects include:

  • Cytokine Release Syndrome (CRS). Tell your healthcare provider right away if you get any of the following symptoms:
  • fever
  • tiredness or weakness
  • vomiting
  • chills
  • nausea
  • low blood pressure
  • dizziness and light headedness
  • headache
  • wheezing and trouble breathing
  • rash

    • Your healthcare provider will check for these problems during treatment. Your healthcare provider may temporarily stop or completely stop your treatment if you have severe side effects.

    See Kimmtrak side effects for more information about side effects.

    What other drugs will affect Kimmtrak

    Tell your healthcare provider about all medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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