Krystexxa
Generic name: Pegloticase
Brand names: Krystexxa
Drug class:
Antihyperuricemic agents
Usage of Krystexxa
Krystexxa is an enzyme that metabolizes uric acid into a harmless chemical that is eliminated from the body in urine. People with gout have too much uric acid in their bodies. Uric acid crystals collect in joints, kidneys, and other organs, and may cause pain, redness and swelling (inflammation).
Krystexxa injection is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.
Krystexxa is usually given after other gout medications have been tried without successful treatment of symptoms.
Krystexxa side effects
Get emergency medical help if you have any signs of an allergic reaction to Krystexxa: hives; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects may occur during the injection. Tell your caregiver if you feel nervous, light-headed, itchy, short of breath, or have fast heartbeats, chest discomfort, or redness of your skin during the injection.
Call your doctor at once if you have:
Common Krystexxa side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Krystexxa
You should not be treated with Krystexxa if you are allergic to pegloticase, or if you have a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Some medicines can cause unwanted or dangerous effects when used with Krystexxa. Your doctor may change your treatment plan if you also use:
Tell your doctor if you have ever had:
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.
Relate drugs
- Duzallo
- Elitek
- Febuxostat
- Krystexxa
- Lesinurad and allopurinol
- Pegloticase
- Rasburicase
- Uloric
- Zurampic
How to use Krystexxa
Usual Adult Dose for Gout:
8 mg every two weeks given as an intravenous infusion, co-administered with weekly methotrexate 15 mg orally. Krystexxa alone may be used in patients for whom methotrexate is contraindicated or not clinically appropriate. Comment: -Patients should receive premedications (e.g., antihistamines, corticosteroids) to minimize the risk of anaphylaxis and infusion reactions. Use: For the treatment of chronic gout in patients who are refractory to conventional therapy (e.g., patients who have failed to normalize serum uric acid and whose signs/symptoms are inadequately controlled with xanthine oxidase inhibitors at the maximum medically appropriate dose or for whom these drugs are contraindicated)
Warnings
You should not receive Krystexxa if you are allergic to pegloticase, or if you have a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Some drugs can interact with Krystexxa and should not be used at the same time, especially allopurinol (Zyloprim), probenecid (Benemid), or febuxostat (Uloric).
Tell your caregivers right away if you feel itchy, light-headed, short of breath, or have chest discomfort or skin redness during the injection.
You may be given other medications to prevent certain side effects of Krystexxa. You may need to start taking these medications at least a week before you receive your injection. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Tell your caregiver right away if you feel itchy, nervous, light-headed, short of breath, or have a fast heartbeat, chest discomfort, or redness of your skin when the medicine is injected into your vein.
What other drugs will affect Krystexxa
Other drugs may interact with pegloticase, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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