Kyprolis

Generic name: Carfilzomib
Dosage form: Infusion
Drug class: Proteasome inhibitors

Usage of Kyprolis

Kyprolis (Carfilzomib) is a cancer medicine used to treat types of multiple myeloma when other medicines have not worked or have stopped working. Kyprolis is from a class of medicines called proteasome inhibitors that slow the spread of cancer and cause cancer cells to die. Multiple myeloma is a cancer of plasma cells (a type of white blood cell).

Kyprolis works by blocking proteasome, which normally breaks down damaged or unneeded proteins within cells. This means that more abnormal proteins build up in the cancer cells, which causes the cancer cells to die.

Kyprolis became an FDA-approved medicine on July 20, 2012.

Kyprolis side effects

Common Kyprolis side effects may include:

fever, bruising, pale skin or other signs of low blood cell counts;

feeling short of breath;

low potassium;

nausea, diarrhea;

cold symptoms such as stuffy nose, sneezing, cough, sore throat;

muscle spasm;

swelling in your hands or feet; or

headache, trouble sleeping, and feeling tired.

Serious Kyprolis side effects

Get emergency medical help if you have signs of an allergic reaction to Kyprolis: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur within 24 hours after the injection. Tell your caregiver right away if you feel weak, nauseated, chilled or feverish, light-headed, or if you have joint or muscle pain, a cold sweat, chest pain or tightness, trouble breathing, or swelling in your face.

Kyprolis may cause a serious brain infection that can lead to disability or death. Call your doctor right away if you have problems with speech, thought, vision, or muscle movement. These symptoms may start gradually and get worse quickly.

Also, call your doctor at once if you have:

a light-headed feeling, like you might pass out;

easy bruising or bleeding (nosebleeds, bleeding gums), or any bleeding that will not stop;

vomiting, diarrhea, weakness, blood in your stools, coughing up blood or vomit that looks like coffee grounds;

headache, confusion, dizziness, problems with balance;

a seizure;

jaundice (yellowing of the skin or eyes);

heart problems - chest pain, pain spreading to your jaw or shoulder, pounding in your neck or ears, blurred vision, severe headache;

kidney problems - little or no urination, swelling in your feet or ankles, feeling tired or short of breath;

low blood cell counts - fever, chills, tiredness, mouth sores, skin sores, pale skin, cold hands and feet;

lung problems - shortness of breath (even while lying down), wheezing, blue-colored lips, and skin, cough with foamy mucus;

low potassium level - leg cramps, irregular heartbeats, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling;

signs of a blood clot - sudden numbness or weakness, slurred speech, pain or redness in an arm or leg; or

signs of tumor cell breakdown - weakness, muscle cramps, nausea, vomiting, fast or slow heart rate, decreased urination, tingling in your hands and feet or around your mouth.

This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Kyprolis

To make sure Kyprolis is safe for you, tell your doctor if you have ever had:

kidney disease (or if you are on dialysis);

heart disease, high blood pressure;

a heart attack or stroke;

lung disease;

liver disease, or abnormal liver function tests.

Consider antiviral prophylaxis to decrease the risk of shingles reactivation (herpes zoster).

Pregnancy

You should not use Kyprolis if you are pregnant or planning to become pregnant, or if you plan to father a child. if you are a female of reproductive potential you may be required to do a pregnancy test before starting Kyprolis treatment.

Kyprolis can harm an unborn baby if the mother or the father is using this medicine.

If you are a woman, do not use Kyprolis if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.

If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.

Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Kyprolis.

Breastfeeding

Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.

Relate drugs

How to use Kyprolis

Your healthcare provider will work out the correct dose and regime for your treatment.

Kyprolis once weekly20/70 mg/m2 (30-minute infusion) is administered in combination with:

dexamethasone (Kd),

daratumumab plus dexamethasone (DKd), or

daratumumab and hyaluronidase-fihj plus dexamethasone (DKd).

Kyprolis twice weekly 20/56 mg/m2 (30-minute infusion) is administered as monotherapy or in combination with:

dexamethasone (Kd),

daratumumab plus dexamethasone (DKd),

daratumumab and hyaluronidase-fihj plus dexamethasone (DKd), or

isatuximab plus dexamethasone (Isa-Kd).

Kyprolis twice Weekly 20/27 mg/m2 (10-minute infusion) is administered as monotherapy or in combination with

lenalidomide and dexamethasone (KRd).

For more detailed information on Kyprolis dosing click the link below.

Warnings

Kyprolis can affect your heart or lungs. Call your doctor at once if you have chest pain, pounding heartbeats, shortness of breath (even with mild exertion or while lying down), swelling of your hands or feet, feeling like you might pass out, wheezing, gasping for breath, cough with foamy mucus, or blue-colored appearance of your lips and skin.

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