L-tryptophan

Generic name: L-tryptophan
Brand names: Tryptan
Dosage form: oral capsule (500 mg)

Usage of L-tryptophan

L-tryptophan is an amino acid that is made from plant or animal sources. L-tryptophan is known as an "essential" amino acid because the body does not produce it. L-tryptophan is important to the functions of many organs in the body. When you consume L-tryptophan, your body absorbs it and changes it to eventually become a hormone called serotonin. Serotonin transmits signals between your nerve cells and also narrows (constricts) blood vessels. The amount of serotonin in the brain can affect mood.

L-tryptophan has been used in alternative medicine as a possibly effective aid in treating symptoms of premenstrual dysphoric disorder syndrome (such as mood swings and irritability), and to help people quit smoking.

L-tryptophan has also been used to treat facial pain, to relieve bruxism (tooth grinding), and to improve athletic performance. However, research has shown that L-tryptophan may not be effective in treating these conditions.

Other uses not proven with research include treating sleep problems (insomnia), anxiety, depression, and attention deficit hyperactivty disorder (ADHD).

It is not certain whether L-tryptophan is effective in treating any medical condition. Medicinal use of this product has not been approved by the FDA. L-tryptophan should not be used in place of medication prescribed for you by your doctor.

L-tryptophan is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

It may be dangerous to purchase L-tryptophan on the Internet or from vendors outside of the United States. The manufacture, sale, and distribution of L-tryptophan outside of the U.S. does not comply with the regulations of the Food and Drug Administration (FDA) for the safe use of this medication.

L-tryptophan may also be used for purposes not listed in this product guide.

L-tryptophan side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Although not all side effects are known, L-tryptophan is thought to be possibly unsafe. Be sure to use this product only if you have obtained it from a safe and reputable source.

In 1989, a life-threatening condition called eosinophilia-myalgia syndrome (EMS) occurred in many people using L-tryptophan and some died from the condition. All of these people had taken L-tryptophan distributed by a company in Japan. This L-tryptophan was found to contain trace levels of impure ingredients. Since that time, the FDA has limited the availability of L-tryptophan in the U.S. However, the increased use of the Internet has made many dietary supplements available from non-U.S. sources.

Although there have been no published cases of EMS within the last several years, you should be aware of the symptoms. Stop using L-tryptophan and seek emergency medical help if you have signs of EMS:

unusual tiredness;

severe muscle pain (most often in the shoulders, back, or legs);

weakness, numbness, tingling, or burning pain (especially at night);

tremors or twitching muscle movements;

swelling in any part of your body;

skin changes (dryness, yellowing, hardening, rash, hair loss);

breathing difficulty; or

uneven heartbeat.

Common side effects of L-tryptophan may include:

feeling drowsy or light-headed;

dry mouth, heartburn, burping, gas;

stomach pain, nausea, vomiting, diarrhea;

weakness, lack of coordination;

blurred vision;

headache; or

sexual problems.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking L-tryptophan

You should not use this product if you are allergic to tryptophan.

Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use this product if you have:

liver disease;

kidney disease;

eosinophilia (high levels of a certain type of white blood cells); or

a muscle disorder (such as fibromyalgia).

L-tryptophan is considered likely unsafe to use during pregnancy. Do not use this product without medical advice if you are pregnant.

It is not known whether L-tryptophan passes into breast milk or if it could harm a nursing baby. Do not use this product without medical advice if you are breast-feeding a baby.

Do not give any herbal/health supplement to a child without medical advice.

Warnings

Follow all directions on the product label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What other drugs will affect L-tryptophan

Taking L-tryptophan with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking L-tryptophan with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Do not take L-tryptophan without medical advice if you are using any of the following medications:

tramadol (Ultram, Ultracet);

a cough medicine that contains dextromethorphan (Delsym, Robitussin DM, and others);

an MAO inhibitor such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others;

medicine to treat mental illness such as chlorpromazine (Thorazine), fluphenazine (Prolixin), thioridazine (Mellaril), and others;

a narcotic medicine such as meperidine (Demerol) or pentazocine (Talwin); or

a sedative such as diazepam (Valium), clonazepam (Klonopin), lorazepam (Ativan), and others.

This list is not complete. Other drugs may interact with L-tryptophan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this product guide.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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