Laronidase
Generic name: Laronidase
Brand names: Aldurazyme
Dosage form: intravenous solution (2.9 mg/5 mL)
Drug class:
Lysosomal enzymes
Usage of Laronidase
Laronidase contains an enzyme that occurs naturally in the body in healthy people. Some people lack this enzyme because of a genetic disorder. Laronidase helps replace this missing enzyme in such people.
Laronidase is used to treat some of the symptoms of a genetic condition called mucopolysaccharidosis (MYOO-koe-pol-ee-SAK-a-rye-DOE-sis) or MPS I, also called Hurler syndrome, Hurler-Scheie syndrome, or Scheie syndrome.
MPS I is a metabolic disorder in which the body lacks the enzyme needed to break down certain substances. These substances can build up in the body, causing enlarged organs, abnormal bone structure, changes in facial features, breathing problems, heart problems, vision or hearing loss, and changes in mental or physical abilities.
Laronidase may improve breathing and walking ability in people with this condition. However, this medication is not a cure for MPS I.
Laronidase may also be used for purposes not listed in this medication guide.
Laronidase side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
An allergic reaction may occur during or shortly after infusion of laronidase (up to 3 hours later). Tell your caregivers or get emergency medical help right away if you have any signs of a severe allergic reaction, such as:
Common side effects of laronidase may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Laronidase
Your laronidase infusion may be delayed if you have a fever or cold symptoms.
Tell your doctor if you have ever had:
Tell your doctor if you are pregnant or breastfeeding.
It is not known whether laronidase will harm an unborn baby. However, MPS symptoms can get worse during pregnancy and may cause medical problems in both mother and baby. The benefit of treating MPS may outweigh any risks to the baby.
Your name may need to be listed on an MPS I Registry while you are using laronidase. The purpose of this registry is to track the progression of this disorder and the effects that laronidase has on long-term treatment of MPS I. The registry also tracks the effects of laronidase on a baby if you are pregnant or breastfeeding.
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How to use Laronidase
Usual Adult Dose for Mucopolysaccharidosis Type I:
0.58 mg/kg IV once a weekComments:-Clinical studies did not include patients 65 years and older and it is therefore unknown if they respond differently than younger patients.Uses: For the treatment of Hurler and Hurler-Scheie forms of Mucopolysaccharidosis I (MPS I) and for patients with the Scheie forms who have moderate to severe symptoms; risk and benefits of treating mildly affected patients with the Scheie form have not been established
Usual Pediatric Dose for Mucopolysaccharidosis Type I:
6 months or older: 0.58 mg/kg IV once a weekUses: For the treatment of Hurler and Hurler-Scheie forms of MPS I and for patients with the Scheie forms who have moderate to severe symptoms; risk and benefits of treating mildly affected patients with the Scheie form have not been established
Warnings
An allergic reaction may occur during or shortly after infusion of this medicine. Tell your caregivers or get emergency medical help right away if you have any signs of a severe allergic reaction, such as sweating, chest discomfort, trouble breathing, pale skin, blue lips or fingernails, and feeling like you might pass out.
What other drugs will affect Laronidase
Other drugs may affect laronidase, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Disclaimer
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The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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