Larotrectinib

Generic name: Larotrectinib
Brand names: Vitrakvi
Drug class: Multikinase inhibitors

Usage of Larotrectinib

Larotrectinib is used to treat certain tumors that are caused by an abnormal "NTRK" gene. Larotrectinib is used when the cancer has spread to other parts of the body or cannot be removed with surgery or other cancer treatments.

Larotrectinib is sometimes given after other cancer treatments did not work or have stopped working.

Larotrectinib was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to larotrectinib, but further studies are needed.

Larotrectinib may also be used for purposes not listed in this medication guide.

Larotrectinib side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Larotrectinib may cause serious side effects. Call your doctor at once if you have:

severe or ongoing stomach pain, vomiting, or diarrhea;

confusion, memory problems, severe dizziness;

problems with speech or coordination;

numbness, tingling, or burning pain in your hands or feet;

fever, flu symptoms, sore throat, cough;

sores or ulcers in your mouth or on your skin;

unusual tiredness, feeling light-headed or short of breath;

pale skin, cold hands and feet;

pain, warmth, redness, or swelling under your skin; or

liver problems--loss of appetite, stomach pain (upper right side), nausea, vomiting, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of larotrectinib may include:

nausea, vomiting, diarrhea, constipation;

cough;

dizziness;

tiredness; or

abnormal liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Larotrectinib

Tell your doctor if you have ever had:

liver disease; or

nerve problems.

You may need to have a negative pregnancy test before starting this treatment.

Both men and women using larotrectinib should use effective birth control to prevent pregnancy. Larotrectinib can harm an unborn baby or cause birth defects if the mother or father is using this medicine. Keep using birth control for at least 1 week after your last dose.

This medicine may affect fertility (ability to have children) in women. However, it is important to use birth control to prevent pregnancy because larotrectinib can harm an unborn baby.

Do not breast-feed while using this medicine, and for at least 1 week after your last dose.

Relate drugs

How to use Larotrectinib

Usual Adult Dose for Solid Tumors:

Body surface area least 1 m2:100 mg orally 2 times a day until disease progression or unacceptable toxicityComments:-Select patients for treatment with this drug based on the presence of a NTRK gene fusion in tumor specimens. Use: For the treatment of adult patients with solid tumors that:-Have a neurotrophic receptor tyrosine kinase (NTRK) gene fusion without a known acquired resistance mUTAtion-Are metastatic or where surgical resection is likely to result in severe morbidity -Have no satisfactory alternative treatments or that have progressed following treatment

Usual Pediatric Dose for Solid Tumors:

28 days and older:-Body surface area at least 1 m2: 100 mg orally 2 times a day until disease progression or unacceptable toxicity-Body surface area less than 1 m2: 100 mg/m2 orally 2 times a day until disease progression or unacceptable toxicity.Comments:-Select patients for treatment with this drug based on the presence of a NTRK gene fusion in tumor specimens. Use: For the treatment of pediatric patients with solid tumors that:-Have a neurotrophic receptor tyrosine kinase (NTRK) gene fusion without a known acquired resistance mutation-Are metastatic or where surgical resection is likely to result in severe morbidity-Have no satisfactory alternative treatments or that have progressed following treatment

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What other drugs will affect Larotrectinib

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect larotrectinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

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