Lasmiditan

Generic name: Lasmiditan
Brand names: Reyvow
Dosage form: oral tablet
Drug class: Antimigraine agents

Usage of Lasmiditan

Lasmiditan is a type of drug called a ditan. It is an abortive migraine medication, which means it is used to help treat a migraine attack rather than prevent a migraine headache. Lasmiditan comes as a tablet.

In 2020, lasmiditan was the first ditan to be approved by the US Food and Drug Administration (FDA).

Lasmiditan works by blocking the pain pathways in the brain. It is a serotonin (5-HT)1F receptor agonist, but its exact mechanism of action is unknown.

Unlike triptans, which are the gold-standard of treatment for migraines, lasmiditan does not constrict blood vessels in the heart and brain.

Lasmiditan side effects

Lasmiditan can cause serious side effects including:

  • See “Important information”
  • serotonin syndrome. Serotonin syndrome is a rare but serious problem that can happen in people using lasmiditan, especially if lasmiditan is used with anti-depressant medicines called SSRIs or SNRIs. Call your healthcare provider right away if you have any of the following symptoms of serotonin syndrome:
  • mental changes such as seeing things that are not there (hallucinations), agitation, or coma
  • fast heartbeat
  • changes in blood pressure
  • high body temperature
  • tight muscles
  • trouble walking
  • nausea, vomiting, or diarrhea
  • medication overuse headache. Some people who take medicines like lasmiditan for the acute treatment of migraine attacks for 10 or more days each month may have worse headaches (medication overuse headache). If your headaches get worse, your healthcare provider may decide to stop your treatment with lasmiditan.

    • The most common side effects of lasmiditan include:

  • dizziness
  • sleepiness
  • numbness
  • feeling tired
  • tingling

    • Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

    These are not all of the possible side effects of lasmiditan. For more information ask your healthcare provider or pharmacist.

    Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Lilly at 1-800-LillyRx (1-800-545-5979).

    Before taking Lasmiditan

    Tell your doctor if your are pregnant or plan to become pregnant. It is not known if lasmiditan will harm your unborn baby.

    There is a pregnancy registry for women who take lasmiditan. The purpose of this registry is to collect information about the health of you and your baby. To learn more call 1-833-464-4724 or visit www.migrainepregnancyregistry.com. You may also talk to your healthcare provider about how you can take part in this registry.

    Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if lasmiditan passes into your breastmilk.

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    How to use Lasmiditan

  • The recommended dose of lasmiditan is 50 mg, 100 mg, or 200 mg taken orally, as needed.
  • No more than one dose should be taken in 24 hours.
  • Administer tablets whole.

    • Warnings

  • Do not drive or operate machinery for at least 8 hours after you take lasmiditan, even if you feel well enough.
  • You should not take lasmiditan if you cannot wait at least 8 hours between taking lasmiditan and driving or operating machinery.

    • What other drugs will affect Lasmiditan

    Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Your healthcare provider will decide if you can take lasmiditan with your other medicines.

    Especially, tell your healthcare provider if you take:

  • propranolol or other medicines that can lower your heart rate
  • any medicines that can increase your blood pressure
  • any medicines that make you sleepy
  • anti-depressant medicines called:
  • selective serotonin reuptake inhibitors (SSRIs)
  • serotonin norepinephrine reuptake inhibitors (SNRIs)
  • tricyclic anti-depressants (TCAs)
  • monoamine oxidase inhibitors (MAOIs)

    • Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure.

    Know the medicines you take. Keep a list of them and show it to your healthcare provider or pharmacist when you get a new medicine.

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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