Lathyrus

Generic name: Lathyrus Cicero, Lathyrus Odoratus, Lathyrus Sativus
Brand names: Caley Pea, Chickling Vetch, Everlasting Pea, Flat-podded Vetch, Grass Pea, Red Pea, Singletary Pea, Spanish Vetchling, Sweet Pea, White Pea, Wild Pea

Usage of Lathyrus

No animal or clinical data are available regarding the use of Lathyrus for any clinical condition.

Limited in vitro studies have explored the antioxidant(Alirezaei 2014, Polatoğlu 2015, Sarmento 2015, Singh 2013) and antifungal(Khan 2011, Tamburino 2012) properties of isolated chemical constituents of Lathyrus.

Lathyrus side effects

Information is limited. Rhinitis and asthma related to occupational exposure to L. sativus flour have been reported.(Antón Gironés 2005)

Before taking Lathyrus

Avoid use. Adverse effects have been reported; see Toxicology.(Barceloux 2009, Wagstaff 2008)

How to use Lathyrus

Clinical evidence is lacking to support specific dosage recommendations for Lathryus.

Warnings

The seeds and foliage of Lathyrus contain toxic chemicals, primarily the beta isomer of 3-N-oxalyl-L-2,3-diaminopropanoic acid (ODAP), but also alpha-amino-gamma-(isoxazolin-5-on-2-yl)-butyric acid and beta-aminopropionitrile.(Barceloux 2009) Animal studies indicate that the alpha isomer of ODAP is relatively nontoxic, and that the water-soluble beta isomer can be converted to the less toxic alpha isomer by boiling in water and draining.(Barceloux 2009, Onar 2014) Methods of cultivation suggest that concentrations of the toxic beta ODAP are affected by growth conditions, varying from 0.1% to 2.5%.(Fikre 2011, Woldeamanuel 2012)

Lathyrism is a neurologic disorder (neurolathyrism) caused by chronic Lathyrus intoxication rather than acute toxicity; its effects can be reversed in the early stages by cessation of seed consumption.(Barceloux 2009, Enneking 2011) Symptoms include spasticity of the lower extremities and an ataxic gait resulting from increased leg muscle tone with muscle weakness. Other symptoms may include GI distress, urinary frequency, and sexual dysfunction.(Barceloux 2009) The condition is less common in well-nourished adults and postmenopausal women.(Barceloux 2009, Enneking 2011, Onar 2014) Studies in rodents and other animals suggest that some species (such as guinea pigs) are more susceptible to these toxic effects.(Amba 2002, Enneking 2011) The mechanism of action continues to be investigated; current evidence suggests that CNS changes due to neurolathyrism include subarachnoid, pial, and subpial hemorrhage as well as demyelination in the cerebellum.(Enneking 2011, Khandare 2014)

Osteolathyrism in humans, evidenced by skeletal deformities and aortic rupture, may be a manifestation of the sequelae of chronic neurolathyrism.(Barceloux 2009)

What other drugs will affect Lathyrus

None well documented. Studies in guinea pigs suggest that the toxic effects of Lathyrus spp. may be potentiated by vitamin C deficiency(Amba 2002) and by coadministration of manganese.(Enneking 2011, Kumar 2003, Mishra 2009)

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