Lefamulin oral/injection

Generic name: Lefamulin (oral/injection)
Brand names: Xenleta
Drug class: Miscellaneous antibiotics

Usage of Lefamulin oral/injection

Lefamulin is used to treat certain types of pneumonia in adults.

Lefamulin may also be used for purposes not listed in this medication guide.

Lefamulin oral/injection side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Lefamulin may cause serious side effects. Call your doctor at once if you have:

severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose); or

low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.

Common side effects of lefamulin may include:

nausea, vomiting, diarrhea;

sleep problems (insomnia);

low potassium;

headache;

abnormal liver function tests; or

pain, bruising, swelling, or irritation where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Lefamulin oral/injection

You should not use lefamulin if you are allergic to it.

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with lefamulin. Your doctor may change your treatment plan if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Tell your doctor if you have ever had:

a heart rhythm disorder (especially if you take medication to treat it);

long QT syndrome;

liver disease; or

kidney disease (or if you are on dialysis).

You may need to have a negative pregnancy test before starting this treatment.

Lefamulin may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using lefamulin and for at least 2 days after your last dose. Tell your doctor if you become pregnant.

You should not breastfeed within 2 days after using lefamulin. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby.

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How to use Lefamulin oral/injection

Usual Adult Dose for Pneumonia:

IV: 150 mg IV every 12 hours for 5 to 7 daysOral: 600 mg orally every 12 hours for 5 daysComments:-May switch from IV to oral dosing to complete the course of therapyUse: For the treatment of community-acquired bacterial pneumonia due to susceptible Streptococcus pneumoniae, Staphylococcus aureus (methicillin-susceptible isolates), Haemophilus influenzae, Legionella pneumophila, Mycoplasma pneumoniae, Chlamydophila pneumoniae

Warnings

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

What other drugs will affect Lefamulin oral/injection

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Lefamulin can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Many drugs can affect lefamulin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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