Leqvio Injection

Generic name: Inclisiran
Dosage form: subcutaneous injection (284 mg/1.5 mL)
Drug class: Miscellaneous antihyperlipidemic agents

Usage of Leqvio Injection

Leqvio (inclisiran) is a prescription medicine used to lower LDL-C cholesterol levels for adults with certain types of high cholesterol (primary hyperlipidemia). Leqvio reduces ‘bad’ low-density lipoprotein cholesterol (LDL-C) and is used with diet and statin therapy.

Leqvio works by blocking a protein in the liver, this increases LDL-C clearance, which lowers the amount of 'bad' cholesterol in your blood. The protein it blocks is proprotein convertase subtilisin kexin type 9 (PCSK9). Leqvio is a small interfering RNA (siRNA) and was the first medication of its class to be approved to lower 'bad' LDL cholesterol.

Leqvio is given as an injection under the skin (suBCutaneous) as a first dose, then a second dose at 3 months, and then every 6 months after that.

Leqvio Injection side effects

Common Leqvio side effects

redness, pain, or bruising where an injection was given;

pain in your legs and arms;

diarrhea;

breathing problems, bronchitis;

joint pain; or

pain and burning when you urinate (this is a serious side effect - call your doctor)

Serious Leqvio side effects

Get emergency medical help if you have signs of an allergic reaction: hives, severe itching, difficulty breathing, swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

pain and burning when you urinate.

This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Leqvio Injection

Do not receive this medicine if you are allergic to the active ingredient inclisiran or inactive ingredients in this medication. See below for a complete list of ingredients.

Tell your doctor if you use other medicines or have other medical conditions, including severe kidney disease, are receiving dialysis, or have severe liver disease.

You should not have this injection if you are under 18 years of age.

Pregnancy

Tell your doctor if you are pregnant, become pregnant, or plan to become pregnant. The use of this medicine should be avoided during pregnancy.

Breastfeeding

Tell your doctor if you are breastfeeding or plan to breastfeed. It is not yet known whether this medicine passes into human breast milk. Your doctor will consider the potential benefits of treatment for you and the risks to your baby compared to the risks of breastfeeding for your baby.

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How to use Leqvio Injection

The recommended dosage of Leqvio:

284 mg given as a single subcutaneous injection initially, again at 3 months, and then every 6 months.

Leqvio is available in a single-dose prefilled syringe 284 mg/1.5 mL (189 mg/mL).

Inclisiran is only part of a complete treatment program that includes diet, statin medication, and regular blood testing.

What other drugs will affect Leqvio Injection

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Leqvio is not expected to cause drug-drug interactions or to be affected by inhibitors or inducers of cytochrome P450 enzymes or transporters.

Disclaimer

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