Letermovir oral/injection

Generic name: Letermovir (oral/injection)
Brand names: Prevymis
Drug class: Miscellaneous antivirals

Usage of Letermovir oral/injection

Letermovir is an antiviral medicine used to help prevent cytomegalovirus (CMV) infection after a stem cell (bone marrow) transplant from a donor. Letermovir is for use in adults who are seropositive for CMV. Seropositive means that the virus is in your blood even if you do not show any symptoms of infection.

A CMV-seropositive person is at risk for "reactivation" of the virus if the immune system becomes weak. While normally treatable, CMV infection can be serious in people undergoing a stem cell transplant.

Letermovir may also be used for purposes not listed in this medication guide.

Letermovir oral/injection side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Letermovir may cause serious side effects. Call your doctor at once if you have:

fast or irregular heartbeats.

Serious side effects may occur if you also use certain other medications.

Common side effects of letermovir may include:

nausea, diarrhea, vomiting, stomach pain;

swelling in your arms or legs;

cough;

headache; or

feeling tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Letermovir oral/injection

Some medicines can cause unwanted or dangerous effects when used with letermovir. Your doctor may need to change your treatment plan if you use any of the following drugs:

pimozide;

cholesterol medication--pitavastatin, simvastatin; or

ergot medicine--dihydroergotamine, ergotamine, ergonovine, methylergonovine.

Tell your doctor if you have ever had:

kidney disease;

liver disease;

diabetes; or

high cholesterol or triglycerides (a type of fat in the blood).

Tell your doctor if you are pregnant or breastfeeding.

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How to use Letermovir oral/injection

Usual Adult Dose for CMV Prophylaxis:

480 mg orally or IV once a dayDuration of therapy: Through Day 100 posttransplantationComments:-This drug should be started between Day 0 and Day 28 posttransplantation (before or after engraftment).Use: For the prophylaxis of cytomegalovirus (CMV) infection and disease in CMV-seropositive recipients [R+] of an allogeneic hematopoietic stem cell transplant (HSCT)

Warnings

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact with letermovir, and some drugs should not be used together.

What other drugs will affect Letermovir oral/injection

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current medicines and any you start or stop using. If you also use cyclosporine, your letermovir dose will need to be adjusted.

Other drugs may affect letermovir, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

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