Levobunolol

Generic name: Levobunolol
Drug class: Ophthalmic glaucoma agents

Usage of Levobunolol

Levobunolol eye drops is used alone or together with other medicines to lower pressure inside the eye that is caused by open-angle glaucoma or ocular (eye) hypertension. This medicine is a beta-blocker.

This medicine is available only with your doctor's prescription.

Levobunolol side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Burning or stinging in the eye

drainage from the eye

redness, swelling, or itching of the eye and eyelid

Less common

Blurred vision

chest pain or discomfort

confusion

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

slow or irregular heartbeat

sweating

unusual tiredness or weakness

Rare

Eye pain

headache

hives or welts, itching, or skin rash

redness of the skin

shakiness and unsteady walk

tearing

unsteadiness, trembling, or other problems with muscle control or coordination

unusual drowsiness, dullness, or feeling of sluggishness

Incidence not determined

Blistering, peeling, or loosening of the skin

blue lips, fingernails, or skin

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chills

cough

decreased urine output

diarrhea

difficult or labored breathing

difficulty in chewing, swallowing, or talking

dilated neck veins

disturbed color perception

double vision

drooping eyelids

extreme tiredness or weakness

fast, pounding, or racing heartbeat or pulse

fever

halos around lights

hoarseness

inability to speak

irregular, fast or slow, or shallow breathing

joint pain, stiffness, or swelling

muscle pain or weakness

night blindness

no blood pressure or pulse

noisy breathing

overbright appearance of lights

red skin lesions, often with a purple center

seeing double

seizures

severe numbness, especially on one side of the face or body

severe or sudden headache

slurred speech

sore throat

sores, ulcers, or white spots in the mouth or on the lips

stopping of the heart

swelling of the eyelids, face, lips, hands, fingers, feet, or lower legs

temporary blindness

tightness in the chest

tunnel vision

unconsciousness

weakness in the arm or leg on one side of the body, sudden and severe

weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not determined

Decreased interest in sexual intercourse

discouragement

feeling of having something in the eye

feeling sad or empty

inability to have or keep an erection

irritability

lack of appetite

lack or loss of strength

loss in sexual ability, desire, drive, or performance

loss of interest or pleasure

nausea

stuffy nose

trouble concentrating

trouble sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Levobunolol

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of levobunolol eye drops in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of levobunolol eye drops in the elderly.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Albuterol

Ceritinib

Crizotinib

Darunavir

Diltiazem

Dronedarone

Epinephrine

Fenoldopam

Fingolimod

Formoterol

Indacaterol

Iobenguane I 131

Iohexol

Lacosamide

Levalbuterol

Olodaterol

Oxymetazoline

Ponesimod

Rivastigmine

Salmeterol

Terbutaline

Verapamil

Vilanterol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acarbose

Aceclofenac

Acemetacin

Acetyldigoxin

Albiglutide

Alfuzosin

Alogliptin

Amtolmetin Guacil

Aspirin

Bromfenac

Bufexamac

Bunazosin

Canagliflozin

Celecoxib

Chlorpropamide

Choline Salicylate

Clonixin

Dapagliflozin

Deslanoside

Dexibuprofen

Dexketoprofen

Diclofenac

Diflunisal

Digitoxin

Digoxin

Dipyrone

Doxazosin

Droxicam

Dulaglutide

Empagliflozin

Ertugliflozin

Etodolac

Etofenamate

Etoricoxib

Exenatide

Felbinac

Fenoprofen

Fepradinol

Feprazone

Floctafenine

Flufenamic Acid

Flurbiprofen

Glimepiride

Glipizide

Glyburide

Ibuprofen

Indomethacin

Insulin Aspart, Recombinant

Insulin degludec

Insulin Detemir

Insulin glargine, Recombinant

Insulin Glulisine

Insulin Human Inhaled

Insulin Human Isophane (NPH)

Insulin Human Regular

Insulin Lispro, Recombinant

Ketoprofen

Ketorolac

Linagliptin

Liraglutide

Lixisenatide

Lornoxicam

Loxoprofen

Lumiracoxib

Meclofenamate

Mefenamic Acid

Meloxicam

Metformin

Metildigoxin

Miglitol

Morniflumate

Moxisylyte

Nabumetone

Naproxen

Nateglinide

Nepafenac

Niflumic Acid

Nimesulide

Nimesulide Beta Cyclodextrin

Oxaprozin

Oxyphenbutazone

Parecoxib

Phenoxybenzamine

Phentolamine

Phenylbutazone

Piketoprofen

Pioglitazone

Piroxicam

Pramlintide

Pranoprofen

Prazosin

Proglumetacin

Propyphenazone

Proquazone

Repaglinide

Rofecoxib

Rosiglitazone

Salicylic Acid

Salsalate

Saxagliptin

Sitagliptin

Sodium Salicylate

St John's Wort

Sulindac

Tamsulosin

Tenoxicam

Terazosin

Tiaprofenic Acid

Tolazamide

Tolbutamide

Tolfenamic Acid

Tolmetin

Trimazosin

Urapidil

Valdecoxib

Vildagliptin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Relate drugs

How to use Levobunolol

Use this medicine exactly as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Shake the medicine well just before each use.

To use the eye drops (solution):

Wash your hands with soap and water before and after you use this medicine.

Tilt the head back. Press your finger gently on the skin just beneath the lower eyelid and pull the lower eyelid away from the eye to make a space. Drop the medicine into this space. Let go of the eyelid and gently close the eyes. Do not blink. Keep the eyes closed and apply pressure to the inner corner of the eye with your finger for 1 or 2 minutes to allow the medicine to be absorbed by the eye.

To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye). Also, keep the container tightly closed. Serious damage to the eye and possible loss of vision may result from using contaminated eye medicines.

You should not use the eye drops if you have contact lenses in your eyes. Remove your contact lenses before you use this medicine. Wait at least 15 minutes after you use the medicine before putting the contact lenses back in.

If your doctor ordered two different eye medicines to be used together, wait several minutes before using the second medicine. This will help prevent the second medicine from “washing out” the first one.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take Depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For ophthalmic solution dosage form (eye drops):

For glaucoma or ocular hypertension:

Adults—One to two drops in the affected eye(s) once a day. Your doctor may increase your dose to 1 to 2 drops two times a day, as needed.

Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Warnings

It is very important that your eye doctor (ophthalmologist) check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects.

Do not use this medicine if you are also using a beta-blocker medicine that is taken by the mouth.

If itching, redness, swelling, or other signs of eye or eyelid irritation occur, check with your doctor right away. This may mean that you are allergic to this medicine.

Levobunolol may cause heart failure in some patients. Check with your doctor right away if you are having chest pain or discomfort, dilated neck veins, extreme fatigue, irregular breathing, an irregular heartbeat, shortness of breath, swelling of the face, fingers, feet, or lower legs, or weight gain.

This medicine may cause changes in your blood sugar levels. It may also cover up signs of low blood sugar, such as a rapid pulse rate. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests.

This medicine may cause choroidal detachment (bleeding inside the eye). Talk to your doctor if you have concerns.

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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