Linaclotide

Generic name: Linaclotide
Brand names: Linzess
Dosage form: oral capsule (145 mcg; 290 mcg; 72 mcg)
Drug class: Guanylate cyclase-C agonists

Usage of Linaclotide

Linaclotide is used to treat chronic constipation, or chronic irritable bowel syndrome (IBS) in people who have had constipation as the main symptom.

Linaclotide may also be used for purposes not listed in this medication guide.

Linaclotide side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Linaclotide may cause serious side effects. Stop using linaclotide and call your doctor at once if you have:

severe or ongoing diarrhea; or

diarrhea with dizziness or a light-headed feeling (like you might pass out).

Common side effects of linaclotide may include:

diarrhea;

stomach pain;

gas; or

bloating or full feeling in your stomach.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Linaclotide

You should not use linaclotide if you are allergic to it, or if you have:

a blockage in your intestines (bowel obstruction).

Linaclotide is not approved for use by anyone younger than 6 years old.

Linaclotide should not be given to a child younger than 2 years old. Linaclotide can cause severe diarrhea and severe dehydration in a child younger than 2 years old. Do not give linaclotide to any child or teenager without the advice of a doctor.

Tell your doctor if you are pregnant or breastfeeding.

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How to use Linaclotide

Usual Adult Dose for Irritable Bowel Syndrome with Constipation (IBS-C):

290 mcg orally once a day Use: Treatment of irritable bowel syndrome with constipation (IBS-C)

Usual Adult Dose for Chronic Idiopathic Constipation (CIC):

145 mcg orally once a day Use: Treatment of chronic idiopathic constipation (CIC)

Usual Pediatric Dose for Functional Constipation (FC):

72 mcg orally once a day

Use: Treatment of functional constipation (FC) in pediatric patients 6 to 17 years of age.

Warnings

You should not use linaclotide if you have a blockage in your intestines.

Linaclotide is not approved for use by anyone younger than 6 years old.

Linaclotide should not be given to a child younger than 6 years old. Linaclotide can cause severe diarrhea and fatal dehydration in a child.

What other drugs will affect Linaclotide

Other drugs may affect linaclotide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

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