Liothyronine (Oral)

Generic name: Liothyronine
Drug class: Thyroid drugs

Usage of Liothyronine (Oral)

Liothyronine is used to treat hypothyroidism, a condition wherein the thyroid gland does not produce enough thyroid hormone. It is also used to help decrease the size of enlarged thyroid glands (goiter) and treat thyroid cancer.

Liothyronine is also used in some medical tests to help diagnose problems with the thyroid gland.

This medicine is available only with your doctor's prescription.

Liothyronine (Oral) side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Anxiety

arm, back, or jaw pain

blurred or double vision

chest pain or discomfort

chest tightness or heaviness

crying

decreased bone mineral density

decreased urine output

delusions of persecution, mistrust, suspiciousness, or combativeness

diarrhea

difficulty breathing

dilated neck vein

dizziness

excessive

sweating

extreme tiredness or weakness

eye pain

fainting

false or unusual sense of well-being

fast, pounding, or irregular heartbeat or pulse

feeling of discomfort

feeling of unreality

fever

headache

heat intolerance

impaired fertility

increased appetite

increased blood pressure

irregular breathing

irritability

itching, skin rash

joint swelling

limp pain in the hip or knee

menstrual changes

mental depression

muscle aches, weakness, or cramps

nausea

nervousness

pain or discomfort in the arms, jaw, back, or neck

quick to react or overreact emotionally

rapidly changing moods

restlessness

sense of detachment from self or body

severe headache

slow heartbeat

stomach cramps

swelling of the face, fingers, feet, or lower legs

swollen lymph glands

tremors

trouble sitting still

trouble sleeping

vomiting

weight gain or loss

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Cold, clammy skin

confusion about identity, place, and time

difficulty in speaking

dizziness

double vision

fast, weak pulse

headache

inability to move the arms, legs, or facial muscles

inability to speak

lightheadedness

loss of consciousness

nervousness

seizure

sensitivity to heat

slow speech

sweating

trouble sleeping

weight loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Feeling of warmth

hair loss

redness of the face, neck, arms, and occasionally, upper chest

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Liothyronine (Oral)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of liothyronine in children. Recommended doses should not be exceeded, and the patient should be carefully monitored during treatment.

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of liothyronine in the elderly. However, elderly patients are more likely to have age-related kidney or heart or blood vessel problems, which may require caution and an adjustment in the dose for patients receiving liothyronine.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Furosemide

Iopromide

Midodrine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Ethinyl Estradiol

Kelp

Sevelamer

Sodium Polystyrene Sulfonate

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

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How to use Liothyronine (Oral)

This medicine will need to be taken for the rest of your life of your child's life. Do not stop taking this medicine or change your doses without first checking with your doctor. It may take several weeks before you start to notice an improvement in your symptoms.

If you use medicine to treat high cholesterol (including cholestyramine, colesevelam, colestipol), Kayexalate®, or sevelamer, take liothyronine at least 4 hours before you take any of these medicines.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablet):

For hypothyroidism:

Adults—At first, 25 micrograms (mcg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 75 mcg once a day.

Older adults—At first, 5 mcg once a day. Your doctor may adjust your dose as needed.

Children—At first, 5 mcg once a day. Your doctor may adjust your dose as needed.

For thyroid cancer:

Adults and children—Use and dose must be determined by your doctor.

For thyroid problem diagnosis:

Adults— 75 to 100 micrograms (mcg) once a day for 7 days. Your doctor will give you a radioactive iodine before and after the 7-day liothyronine.

Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Warnings

It is very important that your doctor check your or your child's progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood tests will be needed to check for unwanted effects.

Liothyronine should not be used for the treatment of obesity or for the purpose of losing weight. This medicine is ineffective for weight reduction and when taken in larger amounts, may cause more serious unwanted effects.

Call your doctor right away if you start to have chest pain, fast or irregular heartbeat, excessive sweating, difficulty with breathing, heat intolerance, nervousness, leg cramps, headache, irritability, sleeplessness, tremors, change in appetite, weight gain or loss, vomiting, diarrhea, fever, changes in menstrual periods, hives, or skin rash. These could be symptoms of too much medicine in your body.

This medicine may cause severe hypothyroidism, called myxedema coma, which may be life-threatening and requires immediate medical attention. Check with your doctor right away if you have the following symptoms: weakness, confusion or non-responsiveness, feeling cold, low body temperature, swelling of the body, especially the face, tongue, and lower legs, or difficulty breathing.

For patients with diabetes: It is very important that you keep track of your blood or urine sugar levels as instructed by your doctor. Check with your doctor right away if you notice any changes in your sugar levels.

If you think you have become pregnant while using this medicine, tell your doctor right away. You may need a larger dose of liothyronine while you are pregnant.

Women who are post-menopausal or who use this medicine for a long time may have some bone loss, which could lead to osteoporosis. Talk with your doctor if you have questions or concerns about this.

A temporary loss of hair may occur during the first few months of liothyronine treatment. Ask your doctor about this if you have any concerns.

Make sure any doctor or dentist who treats you knows that you or your child are using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Disclaimer

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