Liqrev

Generic name: Sildenafil
Dosage form: Oral suspension (10 mg/mL)
Drug class: Agents for pulmonary hypertension

Usage of Liqrev

Liqrev (sildenafil) suspension is used for pulmonary arterial hypertension (PAH) to improve adult patients' ability to exercise and to delay clinical worsening. Liqrev works by relaxing the muscles in blood vessels so they become wider this lowers blood pressure in the lungs, and it also increases the amount of blood pumped by the heart (cardiac output).

Liqrev is a phosphodiesterase-5 (PDE-5) inhibitor that has its effect by blocking the enzyme PDE-5. Liqrev is available as an oral suspension that is taken three times a day.

Liqrev, received FDA approval on April 28, 2023.

Liqrev side effects

Get emergency medical help if you have signs of an allergic reaction to this medicine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking Liqrev and get emergency medical help if you have:

  • heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
  • vision changes or sudden vision loss; or
  • erection is painful or lasts longer than 4 hours (prolonged erection can damage the penis).
  • Call your doctor at once if you have:

  • severe shortness of breath, cough with foamy mucus;
  • ringing in your ears, or sudden hearing loss;
  • irregular heartbeat;
  • swelling in your hands, ankles, or feet;
  • a seizure; or (convulsions); or
  • a light-headed feeling, like you might pass out.
  • Common Liqrev side effects may include:

  • flushing (warmth, redness, or tingly feeling);
  • headache, dizziness;
  • abnormal vision (blurred vision, changes in color vision)
  • runny or stuffy nose, nosebleeds;
  • sleep problems (insomnia);
  • muscle pain, back pain; or upset stomach.
  • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Liqrev

    Do not take Liqrev if you take nitrate medicines either regularly or occasionally, as this can increase your risk of having serious and sudden low blood pressure. Nitrates medicine may include nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as "poppers".

    Some medicines can cause unwanted or dangerous effects when used with sildenafil. Tell your doctor about all your current medicines, especially riociguat (Adempas).

    Stop using Liqrev and get emergency medical help if you have sudden vision loss.

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    How to use Liqrev

    Usual Adult Liqrev Dose for Pulmonary Hypertension

  •  20 mg orally three times a day
  • Use: Treatment of PAH (WHO Group I) in adults to improve exercise ability and delay clinical worsening.

    Liqrev is available as 10 mg/mL oral suspension. 

    What other drugs will affect Liqrev

    Do not take Liqrev with similar medications such as avanafil (Stendra), tadalafil (Cialis) or vardenafil (Levitra). Tell your doctor about all other medications you use.

    Tell your doctor about all your other medicines, especially:

  • drugs to treat high blood pressure or a prostate disorder;
  • antifungal medicine - ketoconazole or itraconazole; or
  • medicine to treat HIV/AIDS - ritonavir and others.
  • This list is not complete. Other drugs may interact with sildenafil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

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