Livmarli

Generic name: Maralixibat
Dosage form: oral solution
Drug class: Miscellaneous GI agents

Usage of Livmarli

  • Livmarli is a prescription medicine used to treat cholestatic pruritus (itch) in patients with Alagille syndrome 1 year of age and older.
  • It is not known if this medicine is safe and effective in children under 1 year of age.
  • It is not known if this medicine is safe and effective in adults 65 years of age and older.

    • Livmarli side effects

    Livmarli can cause serious side effects, including:

  • Changes in liver tests. Changes in certain liver tests are common in patients with Alagille syndrome but may worsen during treatment. These changes may be a sign of liver injury and can be serious. Your healthcare provider should do blood tests before starting and during treatment to check your liver function. Tell your healthcare provider right away if you get any signs or symptoms of liver problems, including:
  • nausea or vomiting
  • your skin or the white part of your eye turns yellow
  • dark or brown urine
  • pain on the right side of your stomach (abdomen)
  • loss of appetite
  • Stomach and intestinal (gastrointestinal) problems. Livmarli can cause stomach and intestinal problems, including diarrhea, stomach pain, and vomiting during treatment. Tell your healthcare provider right away if you have any of these symptoms more often or more severely than normal for you.
  • A condition called Fat Soluble Vitamin (FSV) Deficiency caused by low levels of certain vitamins (vitamin A, D, E, and K) stored in body fat. FSV deficiency is common in patients with Alagille syndrome but may worsen during treatment. Your healthcare provider should do blood tests before starting and during treatment.
  • Other common side effects reported during treatment were bone fractures and gastrointestinal bleeding.

    • Your healthcare provider may change your dose or temporarily or permanently stop treatment if you have certain side effects. These are not all of the possible side effects. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Livmarli

    Before you start treatment, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver problems.
  • are pregnant or plan to become pregnant. It is not known if Livmarli will harm your unborn baby. Tell your healthcare provider right away if you think that you are pregnant.
  • are breastfeeding or plan to breastfeed. It is not known if Livmarli passes into your breast milk. Talk with your healthcare provider about the best way to feed your baby if you take Livmarli.

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    How to use Livmarli

    Usual Adult Dose and Usual Pediatric Dose for Cholestatic Pruritus in Patients with Alagille Syndrome:

    - 380 mcg/kg once daily, taken 30 minutes before the first meal of the day. Starting dose is 190 mcg/kg orally once daily, and should be increased to 380 mcg/kg once daily after one week, as tolerated.

    Use: cholestatic pruritus in patients with Alagille syndrome (ALGS) 1 year of age and older. 

    What other drugs will affect Livmarli

    Tell your healthcare provider about all medicines that you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine. Livmarli may affect the way some other medicines work, and some other medicines may affect the way Livmarli works.

    Especially tell your doctor if you take:

  • certain medicines for high cholesterol - cholestyramine, colesevelam, or colestipol. These medicines least should be taken at least 4 hours before or 4 hours after taking Livmarli.

    • Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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