Lodine

Generic name: Etodolac
Drug class: Nonsteroidal anti-inflammatory drugs

Usage of Lodine

Lodine is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.

Lodine is used to treat mild to moderate pain, osteoarthritis, or rheumatoid arthritis.

Lodine may also be used for purposes not listed in this medication guide.

Lodine side effects

Get emergency medical help if you have signs of an allergic reaction to Lodine: (hives, runny or stuffy nose, wheezing, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, swelling in your legs, feeling short of breath.

Stop using Lodine and call your doctor at once if you have:

changes in your vision;

any skin rash, no matter how mild;

shortness of breath (even with mild exertion);

swelling or rapid weight gain;

signs of stomach bleeding - bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

liver problems - nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

kidney problems - little or no urination, swelling in your feet or ankles, feeling tired; or

low red blood cells (anemia) - pale skin, unusual tiredness, feeling light-headed, cold hands and feet.

Common Lodine side effects include:

nausea, vomiting, stomach pain, indigestion;

diarrhea, constipation, gas;

dizziness, headache, tired feeling;

rash; or

ringing in your ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Lodine

Lodine can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Lodine may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using this medicine, especially in older adults.

You should not use Lodine if you are allergic to etodolac, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

To make sure Lodine is safe for you, tell your doctor if you have ever had:

heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke;

a heart attack, stroke, or blood clot;

stomach ulcers or bleeding;

asthma;

fluid retention;

liver or kidney disease; or

if you take aspirin to prevent heart attack or stroke.

If you are pregnant, you should not take Lodine unless your doctor tells you to. Taking a NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.

Lodine is not approved for use by anyone younger than 18 years old.

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How to use Lodine

Usual Adult Dose of Lodine for Osteoarthritis:

Immediate Release: -Initial dose: 300 mg orally 2 to 3 times a day or 400 mg to 500 mg orally twice a day -Maintenance dose: A lower dose of 600 mg/day may suffice for long-term use -Maximum dose: 1000 mg/day Extended Release: 400 mg to 1000 mg orally once a day Comments: -Therapeutic response can be seen within 1 week of therapy, however, is most often observed by 2 weeks; doses should be adjusted accordingly after satisfactory response is achieved. Uses: For acute and long-term use in the management of signs and symptoms of osteoarthritis and rheumatoid arthritis

Usual Adult Dose of Lodine for Rheumatoid Arthritis:

Usual Adult Dose of Lodine for Pain:

Immediate Release: 200 mg to 400 mg orally every 6 to 8 hours -Maximum dose: 1000 mg/day Use: For the management of acute pain

Usual Pediatric Dose of Lodine for Juvenile Rheumatoid Arthritis:

Extended Release: 6 to 16 years: 20 to 30 kg: 400 mg orally once a day 31 to 45 kg: 600 mg orally once a day 40 to 60 kg: 480 mg orally once a day Greater than 60 kg: 1000 mg orally once a day 17 to 18 years: 400 mg to 1000 mg orally once a day Use: For the relief of signs and symptoms of juvenile rheumatoid arthritis

Warnings

Lodine can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Lodine may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using etodolac, especially in older adults.

Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to etodolac (such as ibuprofen, ketoprofen, or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen. Do not drink alcohol while taking this medicine. Alcohol can increase the risk of stomach bleeding caused by etodolac. Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). This medicine can make your skin more sensitive to sunlight and sunburn may result.

What other drugs will affect Lodine

Ask your doctor before using Lodine if you take an antidepressant. Taking certain antidepressants with an NSAID may cause you to bruise or bleed easily.

Tell your doctor about all your other medicines, especially:

cyclosporine;

lithium;

methotrexate;

a blood thinner (warfarin, Coumadin, Jantoven);

heart or blood pressure medication, including a diuretic or "water pill"; or

steroid medicine (such as prednisone).

This list is not complete. Other drugs may interact with etodolac, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

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