Lonapegsomatropin

Generic name: Lonapegsomatropin
Brand names: Skytrofa
Dosage form: subcutaneous injection (tcgd 11 mg; tcgd 13.3 mg; tcgd 3 mg; tcgd 3.6 mg; tcgd 4.3 mg; tcgd 5.2 mg; tcgd 6.3 mg; tcgd 7.6 mg; tcgd 9.1 mg)
Drug class: Growth hormones

Usage of Lonapegsomatropin

Lonapegsomatropin is a form of human growth hormone used to treat people 1 year and older who weigh at least 25 lbs (11.5 kg) and have growth problems because of inadequate secretion of growth hormone.

Lonapegsomatropin may also be used for purposes not listed in this medication guide.

Lonapegsomatropin side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Lonapegsomatropin may cause serious side effects. Call your doctor at once if you have:

pain in your knees or hips, walking with a limp;

numbness or tingling in your wrist, hand, or fingers;

severe swelling or puffiness in your hands and feet;

changes in behavior;

vision problems, unusual headaches;

changes in the shape or size of a mole;

pain or swelling in your joints;

pancreatitis--severe pain in your upper stomach spreading to your back, nausea and vomiting;

high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor;

increased pressure inside the skull--severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes; or

signs of an adrenal gland problem--extreme weakness, severe dizziness, weight loss, changes in skin color, feeling very weak or tired.

Common side effects of lonapegsomatropin may include:

cold symptoms such as stuffy nose, sneezing, sore throat;

nosebleed, pinpoint purple or red spots under your skin;

fever;

cough;

stomach pain, nausea, vomiting, diarrhea; or

joint pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Lonapegsomatropin

You should not use lonapegsomatropin if you are allergic to it, or if you have:

a serious illness due to lung failure, or complications from recent surgery, injury, or medical trauma;

closed epiphyses;

active cancer;

eye problems caused by diabetes (diabetic retinopathy); or

Prader-Willi syndrome and you are overweight or have severe breathing problems (including sleep apnea).

Tell your doctor if you have ever had:

cancer (especially during childhood);

diabetes;

a head injury or brain tumor;

childhood brain cancer and radiation treatment;

a pituitary gland disorder;

underactive thyroid;

abnormal curvature of the spine (scoliosis); or

breathing problems, sleep apnea (breathing stops during sleep).

Tell your doctor if you are pregnant or breastfeeding.

Relate drugs

How to use Lonapegsomatropin

Usual Pediatric Dose for Pediatric Growth Hormone Deficiency:

1 year and older and weighing at least 11.5 kg: Recommended dose: 0.24 mg/kg suBCutaneously once a weekComments:-Individualize dose based on response.-Round dose to closest cartridge dose while considering treatment goals and patient response.-If no increase in height velocity, particularly during the first year of treatment, assess compliance and evaluate other causes of poor growth such as hypothyroidism, undernutrition, advanced bone age and antibodies to recombinant human growth hormone.-Discontinue once epiphyseal fusion has occurred.Use: Treatment of pediatric patients 1 year and older who weigh at least 11.5 kg and have growth failure due to inadequate secretion of endogenous growth hormone (GH)

Warnings

Call your doctor at once if you have severe pain in your upper stomach spreading to your back; increased thirst, increased urination; severe headaches, ringing in your ears, dizziness, nausea, vision problems; weight loss, changes in skin color, feeling very weak or tired.

What other drugs will affect Lonapegsomatropin

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Tell your doctor about all your other medicines, especially:

birth control pills or hormone replacement therapy;

insulin or oral diabetes medicine; or

a steroid (prednisone, dexamethasone, methylprednisolone, and others).

This list is not complete. Other drugs may affect lonapegsomatropin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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