Loncastuximab tesirine

Generic name: Loncastuximab Tesirine
Brand names: Zynlonta
Dosage form: intravenous injection (lpyl 10 mg)
Drug class: Miscellaneous antineoplastics

Usage of Loncastuximab tesirine

Loncastuximab tesirine is used to treat large B-cell lymphoma after at least two other cancer treatments did not work or have stopped working.

Loncastuximab tesirine may also be used for purposes not listed in this medication guide.

Loncastuximab tesirine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Loncastuximab tesirine may cause serious side effects. Call your doctor at once if you have:

  • new or worsening skin rash, peeling, redness, or irritation;
  • new or worsening swelling, weight gain, chest pain, shortness of breath, or trouble breathing;
  • fluid build-up in or around the lungs--pain when you breathe, feeling short of breath while lying down, wheezing, gasping for breath, cough with foamy mucus, cold and clammy skin, anxiety, rapid heartbeats;
  • low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; or
  • signs of a serious infection--flu symptoms, cough, weakness, body aches, headache, trouble breathing, or skin wounds with pain, redness, warmth, or swelling.

    • Common side effects of loncastuximab tesirine may include:

  • tiredness or weakness;
  • rash;
  • swelling;
  • nausea;
  • muscle or joint pain;
  • increase in blood sugar; or
  • changes in blood or lab tests.

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Loncastuximab tesirine

    Tell your doctor if you have ever had:

  • liver problems; or
  • an infection.

    • Loncastuximab tesirine can harm an unborn baby if the mother or the father is using loncastuximab tesirine.

  • If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 9 months after your last dose.
  • If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 6 months after your last dose.
  • Tell your doctor right away if a pregnancy occurs.

    • It may be harder for a man to get a woman pregnant while using this medicine. You should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

    Do not breastfeed while using this medicine, and for at least 3 months after your last dose.

    Relate drugs

    How to use Loncastuximab tesirine

    Usual Adult Dose for Lymphoma:

    0.15 mg/kg IV over 30 minutes on Day 1 of each cycle (every 3 weeks) for 2 cycles, then 0.075 mg/kg IV over 30 minutes every 3 weeks for subsequent cyclesComments:-Premedicate with dexamethasone 4 mg orally or IV 2 times a day for 3 days beginning the day before this drug.-If dexamethasone administration does not begin the day before this drug, dexamethasone should begin at least 2 hours prior to administration of this drug.Use: For the treatment of adult patients with relapsed or refractory large B-cell lymphoma after 2 or more lines of systemic therapy, including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, DLBCL arising from low-grade lymphoma, and high-grade B-cell lymphoma

    Warnings

    You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, flu symptoms (cough, tiredness, weakness, body aches), headache, trouble breathing, or skin wounds with pain, redness, warmth, or swelling.

    What other drugs will affect Loncastuximab tesirine

    Other drugs may affect loncastuximab tesirine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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