Lotensin

Generic name: Benazepril
Drug class: Angiotensin Converting Enzyme Inhibitors

Usage of Lotensin

Lotensin (Benazepril) is used alone or in combination with other medications to treat high blood pressure. Benazepril belongs to a class of medications called angiotensin-converting enzyme (ACE) inhibitors.

Lotensin works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly.

High blood pressure is a common condition, and when not treated it can cause damage to the brain, heart, blood vessels, kidneys, and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

Lotensin side effects

Get emergency medical help if you have signs of an allergic reaction to Lotensin: hives, severe stomach pain, difficulty breathing, swelling of your face, lips, tongue, or throat.

Lotensin may cause serious side effects. Call your doctor at once if you have:

a light-headed feeling, like you might pass out;

kidney problems - swelling, urinating less, feeling tired or short of breath;

high blood potassium - nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; or

liver problems - loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common Lotensin side effects may include:

headache; or

cough.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Lotensin

You should not use Lotensin if you are allergic to benazepril or to any other ACE (angiotensin converting enzyme) inhibitor such as Captopril, fosinopril, enalapril, lisinopril, moexipril, perindopril, quinapril, ramipril, or trandolapril.

Do not take Lotensin within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).

If you have diabetes, do not use Lotensin together with any medication that contains aliskiren (a blood pressure medicine).

Do not take Lotensin if you have a history of angioedema (severe allergic reaction).

To make sure Lotensin is safe for you, tell your doctor if you have ever had:

heart disease, heart problems such as a recent heart attack;

stomach pain;

low blood pressure;

if you are on a low-salt diet;

diabetes;

liver disease; or

kidney disease (or if you are on dialysis).

You may also need to avoid taking Lotensin with aliskiren if you have kidney disease.

Stop using this medicine and tell your doctor right away if you become pregnant. Benazepril can cause injury or death to the unborn baby if you use the medicine during your second or third trimester.

Do not breastfeed.

Relate drugs

How to use Lotensin

Usual Adult Dose for Hypertension:

Initial dose: With a diuretic: 5 mg orally once a day; without a diuretic: 10 mg orally once a day Maintenance dose: 20 to 40 mg/day orally as a single dose or in two equally divided doses Maximum dose: 80 mg/day Comments: -The divided dose regimen was more effective in controlling pre-dosing blood pressure. -If discontinuing a diuretic prior to initiating this drug to reduce the likelihood of hypotension, conclude diuretic therapy 2 to 3 days prior to starting this drug.

Usual Pediatric Dose for Hypertension:

6 YEARS OR OLDER: Initial dose: 0.2 mg/kg orally once a day as monotherapy Maximum dose: 0.6 mg/kg; 40 mg/day Comments: -Doses between 0.1 and 0.6 mg/kg once a day have been studied; doses greater than 0.1 mg/kg were shown to reduce blood pressure; doses above 0.6 mg/kg or 40 mg/day have not been studied in pediatric patients. -Prepare a suspension for pediatric patients who cannot swallow tablets or for whom the calculated dosage does not correspond to available tablet strengths.

Warnings

Do not use Lotensin if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away.

You should not use this medicine if you have ever had angioedema. Do not take Lotensin within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).

If you have diabetes, do not use Lotensin together with any medication that contains aliskiren (a blood pressure medicine).

What other drugs will affect Lotensin

Benazepril can harm your kidneys, especially if you also use certain medicines for infections, cancer, or osteoporosis.

Tell your doctor about all your other medicines, especially:

a diuretic or "water pill" that may increase blood potassium such as spironolactone, triamterene, or amiloride;

NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others;

insulin or diabetes medications;

medicine to prevent organ transplant rejection such as temsirolimus, sirolimus, or everolimus; or

heart or blood pressure medication.

This list is not complete. Other drugs may interact with benazepril, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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