Lotilaner (EENT)
Brand names: Xdemvy
Drug class:
Antineoplastic Agents , Antineoplastic Agents
Usage of Lotilaner (EENT)
Lotilaner has the following uses:
Lotilaner is an ectoparasiticide (anti-parasitic) indicated for the treatment of Demodex blepharitis.
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How to use Lotilaner (EENT)
General
Lotilaner is available in the following dosage form(s) and strength(s):
Ophthalmic solution containing lotilaner 0.25%.
Dosage
It is essential that the manufacturer's labeling be consulted for more detailed information on dosage and administration of this drug. Dosage summary:
Adults
Dosage and AdministrationInstill one drop of lotilaner in each eye twice daily (approximately 12 hours apart) for 6 weeks.
Warnings
Contraindications
None.
Warnings/Precautions
Risk of Contamination
Do not allow the tip of the dispensing container to contact the eye, surrounding structures, fingers, or any other surface in order to minimize contamination of the solution. Serious damage to the eye and subsequent loss of vision may result from using contaminated solutions.
Use with Contact Lenses
Contact lenses should be removed prior to instillation of lotilaner and may be reinserted 15 minutes following its administration.
Specific Populations
PregnancyThere are no available data on lotilaner use in pregnant women to inform any drug associated risk; however, systemic exposure to lotilaner from ocular administration is low. In animal reproduction studies, lotilaner did not produce malformations at clinically relevant doses.
LactationThere are no data on the presence of lotilaner in human milk, the effects on the breastfed infant, or the effects on milk production. However, systemic exposure to lotilaner following 6 weeks of topical ocular administration is low and is >99% plasma protein bound; thus it is not known whether measurable levels of lotilaner would be present in maternal milk following topical ocular administration. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for lotilaner and any potential adverse effects on the breast-fed child from lotilaner.
Pediatric UseSafety and effectiveness in pediatric patients below the age of 18 years have not been established.
Geriatric UseNo overall differences in safety or effectiveness have been observed between elderly and other adult patients.
Common Adverse Effects
The most common adverse reaction was instillation site stinging and burning (10%).
What other drugs will affect Lotilaner (EENT)
Specific Drugs
It is essential that the manufacturer's labeling be consulted for more detailed information on interactions with this drug, including possible dosage adjustments. Interaction highlights:
Please see product labeling for drug interaction information.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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