Lotilaner (EENT)

Brand names: Xdemvy
Drug class: Antineoplastic Agents , Antineoplastic Agents

Usage of Lotilaner (EENT)

Lotilaner has the following uses:

Lotilaner is an ectoparasiticide (anti-parasitic) indicated for the treatment of Demodex blepharitis.

Relate drugs

How to use Lotilaner (EENT)

General

Lotilaner is available in the following dosage form(s) and strength(s):

Ophthalmic solution containing lotilaner 0.25%.

Dosage

It is essential that the manufacturer's labeling be consulted for more detailed information on dosage and administration of this drug. Dosage summary:

Adults

Dosage and Administration

Instill one drop of lotilaner in each eye twice daily (approximately 12 hours apart) for 6 weeks.

Warnings

Contraindications

None.

Warnings/Precautions

Risk of Contamination

Do not allow the tip of the dispensing container to contact the eye, surrounding structures, fingers, or any other surface in order to minimize contamination of the solution. Serious damage to the eye and subsequent loss of vision may result from using contaminated solutions.

Use with Contact Lenses

Contact lenses should be removed prior to instillation of lotilaner and may be reinserted 15 minutes following its administration.

Specific Populations

Pregnancy

There are no available data on lotilaner use in pregnant women to inform any drug associated risk; however, systemic exposure to lotilaner from ocular administration is low. In animal reproduction studies, lotilaner did not produce malformations at clinically relevant doses.

Lactation

There are no data on the presence of lotilaner in human milk, the effects on the breastfed infant, or the effects on milk production. However, systemic exposure to lotilaner following 6 weeks of topical ocular administration is low and is >99% plasma protein bound; thus it is not known whether measurable levels of lotilaner would be present in maternal milk following topical ocular administration. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for lotilaner and any potential adverse effects on the breast-fed child from lotilaner.

Pediatric Use

Safety and effectiveness in pediatric patients below the age of 18 years have not been established.

Geriatric Use

No overall differences in safety or effectiveness have been observed between elderly and other adult patients.

Common Adverse Effects

The most common adverse reaction was instillation site stinging and burning (10%).

What other drugs will affect Lotilaner (EENT)

Specific Drugs

It is essential that the manufacturer's labeling be consulted for more detailed information on interactions with this drug, including possible dosage adjustments. Interaction highlights:

Please see product labeling for drug interaction information.

Disclaimer

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