Loxapine (Oral)

Generic name: Loxapine
Drug class: Miscellaneous antipsychotic agents

Usage of Loxapine (Oral)

Loxapine is used to treat a condition called schizophrenia. This medicine should not be used to treat behavioral problems in older adult patients who have dementia.

This medicine is available only with your doctor's prescription.

Loxapine (Oral) side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Difficulty with speaking or swallowing

lip smacking or puckering

loss of balance control

mask-like face

puffing of the cheeks

rapid or fine, worm-like movements of the tongue

restlessness or desire to keep moving

shuffling walk

slowed movements

stiffness of the arms and legs

trembling and shaking of the fingers and hands

uncontrolled chewing movements

uncontrolled movements of the arms or legs

Less common

Constipation (severe)

difficult urination

inability to move the eyes

muscle spasms, especially of the neck and back

skin rash

twisting movements of the body

Rare

Difficult or fast breathing

fast heartbeat or irregular pulse

fever (high)

high or low blood pressure

increased blinking or spasms of the eyelid

increased sweating

loss of bladder control

muscle stiffness (severe)

seizures

sore throat and fever

uncontrolled twisting movements of the neck, trunk, arms, or legs

unusual bleeding or bruising

unusual facial expressions or body positions

unusual tiredness or weakness

unusually pale skin

yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Dizziness, faintness, or lightheadedness when suddenly getting up from a lying or sitting position

drowsiness (severe)

irregular, fast or slow, or shallow breathing

loss of consciousness

muscle trembling, jerking, stiffness, or uncontrolled movements (severe)

pale or blue lips, fingernails, or skin

troubled breathing (severe)

unusual tiredness or weakness (severe)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Blurred vision

confusion

dizziness, lightheadedness, or fainting

drowsiness

dryness of the mouth

Less common

Constipation (mild)

decreased sexual ability

enlargement of the breasts (males and females)

headache

increased sensitivity of the skin to sunlight

missing menstrual periods

nausea or vomiting

trouble with sleeping

unusual secretion of milk

weight gain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Loxapine (Oral)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of loxapine in the pediatric population. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of loxapine in geriatric patients. However, elderly patients (especially females) are more likely to have tardive dyskinesia (a movement disorder), which may require caution in patients receiving loxapine.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Bromopride

Metoclopramide

Potassium Citrate

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acepromazine

Alfentanil

Alprazolam

Amantadine

Amifampridine

Amineptine

Amitriptyline

Amitriptylinoxide

Amobarbital

Amoxapine

Anileridine

Aripiprazole

Asenapine

Baclofen

Belladonna

Belladonna Alkaloids

Benperidol

Benzhydrocodone

Bromazepam

Butorphanol

Calcium Oxybate

Cannabis

Carphenazine

Cetirizine

Chloral Hydrate

Chlordiazepoxide

Chlorpromazine

Chlorzoxazone

Clobazam

Clomipramine

Clonazepam

Clorazepate

Clozapine

Codeine

Cyclobenzaprine

Daridorexant

Desipramine

Dexmedetomidine

Diacetylmorphine

Diazepam

Dibenzepin

Dichloralphenazone

Difenoxin

Dihydrocodeine

Diphenhydramine

Diphenoxylate

Donepezil

Doxepin

Doxylamine

Droperidol

Enflurane

Epinephrine

Esketamine

Estazolam

Eszopiclone

Ethchlorvynol

Ethopropazine

Ethylmorphine

Fentanyl

Flibanserin

Fluphenazine

Flurazepam

Fluspirilene

Fospropofol

Gabapentin

Gabapentin Enacarbil

Glucagon

Glycopyrrolate

Glycopyrronium Tosylate

Halazepam

Haloperidol

Halothane

Hexobarbital

Hydrocodone

Hydromorphone

Hydroxyzine

Imipramine

Isoflurane

Ketamine

Ketazolam

Ketobemidone

Lacosamide

Lemborexant

Levocetirizine

Levorphanol

Lithium

Lofepramine

Lofexidine

Lorazepam

Magnesium Oxybate

Meclizine

Melitracen

Melperone

Meperidine

Mephobarbital

Meprobamate

Meptazinol

Mesoridazine

Metaxalone

Methacholine

Methadone

Methdilazine

Methocarbamol

Methohexital

Methotrimeprazine

Methylene Blue

Midazolam

Molindone

Moricizine

Morphine

Morphine Sulfate Liposome

Nalbuphine

Nicomorphine

Nitrazepam

Nitrous Oxide

Nortriptyline

Olanzapine

Opipramol

Opium

Opium Alkaloids

Orphenadrine

Oxazepam

Oxycodone

Oxymorphone

Papaveretum

Paregoric

Pentazocine

Pentobarbital

Perampanel

Perazine

Periciazine

Perphenazine

Phenobarbital

Pimozide

Piperacetazine

Pipotiazine

Piritramide

Potassium Oxybate

Prazepam

Pregabalin

Primidone

Prochlorperazine

Promazine

Promethazine

Propofol

Protriptyline

Quazepam

Quetiapine

Ramelteon

Remifentanil

Remimazolam

Remoxipride

Revefenacin

Ropeginterferon Alfa-2b-njft

Scopolamine

Secobarbital

Secretin Human

Sertindole

Sodium Oxybate

Sufentanil

Sulpiride

Suvorexant

Tapentadol

Temazepam

Thiethylperazine

Thiopental

Thiopropazate

Thioridazine

Tianeptine

Tilidine

Tiotropium

Tizanidine

Tolonium Chloride

Topiramate

Tramadol

Trazodone

Triazolam

Trifluoperazine

Trifluperidol

Triflupromazine

Trimeprazine

Trimipramine

Zaleplon

Zolpidem

Zopiclone

Zotepine

Zuranolone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Betel Nut

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Relate drugs

How to use Loxapine (Oral)

Take this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered.

To use the oral liquid:

Measure the medicine only with the measuring dropper provided.

Mix the medicine with orange juice or grapefruit juice before drinking.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For schizophrenia:

For oral dosage form (capsules):

Adults—At first, 20 to 50 milligrams (mg) per day, divided and given in two to four doses per day. Your doctor may increase your dose if needed. However, the dose is usually not more than 250 mg per day.

Children—Use and dose must be determined by your doctor.

For oral dosage form (Loxitane® capsules and solution):

Adults—At first, 10 milligrams (mg) 2 times a day. Some patients may need 50 mg per day. Your doctor may increase your dose if needed. However, the dose is usually not more than 250 mg per day.

Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Warnings

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Do not stop taking this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are taking before stopping completely. This will allow your body time to adjust and to keep your condition from becoming worse.

Check with your doctor before using this medicine with alcohol or other medicines that affect the central nervous system (CNS). The use of alcohol or other medicines that affect the CNS with loxapine may worsen the side effects of this medicine, such as dizziness, poor concentration, drowsiness, unusual dreams, and trouble with sleeping. Some examples of medicines that affect the CNS are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicines, medicine for depression, medicine for anxiety, prescription pain medicine or narcotics, medicine for attention deficit and hyperactivity disorder, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics.

This medicine may cause tardive dyskinesia (a movement disorder). Check with your doctor right away if you have any of the following symptoms while taking this medicine: lip smacking or puckering, puffing of the cheeks, rapid or worm-like movements of the tongue, uncontrolled chewing movements, or uncontrolled movements of the arms and legs.

Check with your doctor right away if you have any of the following symptoms while using this medicine: convulsions (seizures), difficulty with breathing, a fast heartbeat, a high fever, high or low blood pressure, increased sweating, loss of bladder control, severe muscle stiffness, unusually pale skin, or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).

This medicine may cause blurred vision, dizziness, drowsiness, trouble with thinking, trouble with controlling body movements, or trouble with your vision, which may lead to falls, fractures or other injuries. Make sure you know how you react to this medicine before you drive, use machines, or do other jobs that require you to be alert, well-coordinated, or able to think or see well.

Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help. If the problem continues or gets worse, check with your doctor.

Loxapine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever, chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.

Check with your doctor immediately if blurred vision, difficulty with reading, or any other change in vision occurs during or after treatment. Your doctor may want your eyes be checked by an ophthalmologist (eye doctor).

Loxapine may cause dry mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental diseases, including tooth decay, gum disease, and fungus infections.

This medicine may increase prolactin blood levels if used for a long time. Check with your doctor if you have breast swelling or soreness, unusual breast milk production, absent, missed, or irregular menstrual periods, stopping of menstrual bleeding, loss in sexual ability, desire, drive, or performance, decreased interest in sexual intercourse, or an inability to have or keep an erection.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines) and herbal or vitamin supplements.

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